Results 31 to 40 of about 288,891 (362)
Targeting the Stress System During Gestation: Is Early Handling a Protective Strategy for the Offspring? [PDF]
, 2020 The perinatal window is a critical developmental time when abnormal gestational stimuli may alter the development of the stress system that, in turn, influences behavioral and physiological responses in the newborns.
Brancato, Anna +3 more
core +3 more sources
, 2016 The most effective anti-inflammatory drugs used to treat patients with airways disease are topical glucocorticosteroids (GCs). These act on virtually all cells within the airway to suppress airway inflammation or prevent the recruitment of inflammatory cells into the airway.
Adcock, IM, Mumby, S
openaire +4 more sources
Obstetric Medicine, 2019 The physiological changes that occur during pregnancy include altered regulation of the hypothalamo-pituitary-adrenal axis. The fetoplacental unit plays a major role in this, together with alteration of circulating cortisol-binding globulin levels, with a net effect to increase both total and free cortisol levels.
Riccardo Pofi +2 more
openaire +5 more sources
The influence of glucocorticoids on neuronal survival and synaptic function
Biomolecular Concepts, 2012 Glucocorticoids, recognized as stress-related steroid hormones secreted from adrenal glands, have multiple roles in brain function. The concentration of glucocorticoids is regulated by the hypothalamic-pituitary-adrenal axis, and chronically elevated ...
Numakawa Tadahiro +4 more
doaj +1 more source
Glucocorticoid-induced osteoporosis – a disorder of mesenchymal stromal cells?
Frontiers in Endocrinology, 2011 Glucocorticoids are a class of steroid hormones that are essential to life but cause serious harm in excess. The main clinical features of glucocorticoid excess are due to adverse effects on cells and tissues that arise from a common developmental ...
Mark Stuart Cooper, Rowan eHardy
doaj +1 more source
Glucocorticoids rapidly inhibit oxytocin-stimulated adrenocorticotropin release from rat anterior pituitary cells, without modifying intracellular calcium transients [PDF]
, 1993 Glucocorticoid hormones suppress the secretion of ACTH evoked by secretagogues such as CRF and arginine vasopressin. In this study, we investigated the effects of glucocorticoids on ACTH release induced by oxytocin (OT) and on intracellular free calcium ...
Dayanithi, G., Gratzl, Manfred, Link, H.
core +1 more source
Glucocorticoids and resilience [PDF]
Hormones and Behavior, 2019 All organisms endure frequent challenges to homeostasis, or stressors, that require adaptation. Depending on the individual, the context, and the magnitude of stress, this active adaptation can lead to behavioral susceptibility or resilience. The latter is an under-appreciated consequence of stress, as the damaging effects of chronic stress and ...
Joanna L. Spencer-Segal +2 more
openaire +3 more sources
Improvement of Treg immune response after treatment with tocilizumab in giant cell arteritis
Clinical & Translational Immunology, 2021 Objectives To study the percentage, suppressive function and plasticity of Treg in giant cell arteritis (GCA), and the effects of glucocorticoids and tocilizumab.
Maxime Samson +27 more
doaj +1 more source
The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ. [PDF]
, 2017 Chronic glucocorticoid exposure is associated with the development of insulin resistance. We showed that glucocorticoid-induced insulin resistance was attenuated upon ablation of Angptl4, a glucocorticoid target gene encoding the secreted protein ...
Benjamin, Daniel I +8 more
core +1 more source
Inhibition of glucocorticoid-induced REDD1 expression by rapamycin in breast cancer cells
Успехи молекулярной онкологии, 2022 Introduction. Glucocorticoids are often used in combination therapy for breast cancer as an adjuvant to increase therapeutic effects of the main cytotoxic drug and to reduce side effects of chemotherapy.
D. D. Grigorieva +7 more
doaj +1 more source