Results 51 to 60 of about 415,196 (303)
Scientific Reports, 2017 Chronic administration of glucocorticoids has been shown to render individuals highly susceptible to mycobacterial infection and lead to reactivation of latent bacilli.
Jinli Wang +7 more
doaj +1 more source
Chronopharmacology of glucocorticoids
Advanced Drug Delivery Reviews, 2019 Glucocorticoids influence a wide array of metabolic, anti-inflammatory, immunosuppressive, and cognitive signaling processes, playing an important role in homeostasis and preservation of normal organ function. Synthesis is regulated by the hypothalamic-pituitary-adrenal (HPA) axis of which cortisol is the primary glucocorticoid in humans.
Megerle L. Scherholz +2 more
openaire +4 more sources
Evidence for the stress-linked immunocompetence handicap hypothesis in humans [PDF]
, 2012 Secondary sexual traits that develop under the action of testosterone, such as masculine human male facial characteristics, have been proposed to signal the strength of the immune system due to the sex hormone's immunosuppressive action.
Kecko, Sanita +6 more
core +4 more sources
Life Course Impact of Glucocorticoids During Pregnancy on Muscle Development and Function
Frontiers in Animal Science, 2021 Maternal stress, such as maternal obesity, can induce severe gestational disease and hormonal disorder which may disrupt fetal organ maturation and further cause endangered early or future health in offspring.
Yang Liu, Qiyue Ding, Wei Guo
doaj +1 more source
Immune regulation by glucocorticoids can be linked to cell type–dependent transcriptional responses
Journal of Experimental Medicine, 2019 Glucocorticoids remain the most widely used immunosuppressive and anti-inflammatory drugs, yet substantial gaps exist in our understanding of glucocorticoid-mediated immunoregulation.
Luis M. Franco +11 more
semanticscholar +1 more source
Journal of Otology, 2020 Background: Evidence suggests that glucocorticoids are important in the treatment of sudden hearing loss (SHL) and Meniere’s disease (MD). However, different glucocorticoid administration methods may have a significant impact on treatment outcomes ...
Dan Chen +7 more
doaj +1 more source
Glucocorticoids, Sex Hormones, and Immunity
Frontiers in Immunology, 2018 Glucocorticoid hormones regulate essential body functions in mammals, control cell metabolism, growth, differentiation, and apoptosis. Importantly, they are potent suppressors of inflammation, and multiple immune-modulatory mechanisms involving leukocyte
O. Bereshchenko +2 more
semanticscholar +1 more source
The glucocorticoid receptor in inflammatory processes : transrepression is not enough [PDF]
, 2015 Glucocorticoids (GCs) are the most commonly used anti-inflammatory agents to treat inflammatory and immune diseases. However, steroid therapies are accompanied by severe side-effects during long-term treatment. The dogma that transrepression of genes, by
Dejager, Lien +3 more
core +2 more sources
Consequences of the Lack of IL-10 in Different Endotoxin Effects and its Relationship With Glucocorticoids [PDF]
, 2019 Sepsis constitutes one of the major causes of death in ICUs. In sepsis induced by gram-negative, although lipopolysaccharide (LPS) initially induces an exacerbated secretion of proinflammatory cytokines leading to endotoxic shock and death resembling a ...
Barrientos, Gabriela Laura +10 more
core +1 more source
Regulation of triglyceride metabolism by glucocorticoid receptor
Cell & Bioscience, 2012 Glucocorticoids are steroid hormones that play critical and complex roles in the regulation of triglyceride (TG) homeostasis. Depending on physiological states, glucocorticoids can modulate both TG synthesis and hydrolysis.
Wang Jen-Chywan +3 more
doaj +1 more source