Results 111 to 120 of about 15,165 (218)

Lifestyle modification in atrial fibrillation: Mechanisms, phenotypes and ablation outcomes

Experimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia and is associated with significant morbidity, mortality and healthcare utilization. Catheter ablation is increasingly used as a rhythm‐control intervention for patients with symptomatic paroxysmal and persistent AF, yet recurrence rates remain suboptimal.
Konstantinos Grigoriou, Paschalis Karakasis, Panagiotis Theofilis, Konstantinos Pamporis, Panayotis K. Vlachakis, Anastasios Apostolos, Nikolaos Ktenopoulos, Barbara Fyntanidou, Efstratios Karagiannidis, Dimitrios Patoulias, Antonios P Antoniadis, Nikolaos Fragakis   +11 more
wiley   +1 more source

(Dis)agreement and concordance of metabolic indices from the oral glucose tolerance test and mixed‐meal tolerance test: Implications for application

Experimental Physiology, EarlyView.
Abstract Metabolic indices derived from the oral glucose tolerance test (OGTT) and mixed‐meal tolerance test (MMTT) are often interpreted interchangeably; however, these tests represent distinct physiological stimuli. In order to examine potential differential metabolic responses to these tests, we characterized the (dis)agreement between OGTT‐ and ...
Nina Sloth Nielsen, Nikolaj Agerlin, Nikolas Antoniou, Helga Ellingsgaard, Kristian Karstoft, Louise Lang Lehrskov, Grit Elster Legård, Mark Preben Printz Lyngbæk, Beckey Trinh, Thomas P. J. Solomon, Marc Y. Donath, Mathias Ried‐Larsen, Cody Garett Durrer   +12 more
wiley   +1 more source

Le récepteur CCK2 dans les cancers : ciblage diagnostique et thérapeutique grâce à la vectorisation de nanoparticules magnétiques

, 2012
Le récepteur CCK2 est un récepteur à 7 domaines transmembranaires couplé aux protéines G. D'un point de vue physiologique, le récepteur CCK2 joue un rôle central dans la régulation de la digestion, et agit également au niveau du système nerveux central ...
Sanchez, Claire
core  

Reproducibility of Splanchnic Blood Flow Measured Using Phase‐Contrast MRI

NMR in Biomedicine, Volume 39, Issue 8, August 2026.
Splanchnic vessel blood flow assessment can describe physiology or pathophysiological conditions. Here, we assessed the variation of PC‐MRI‐determined repeated measures of blood flow in four splanchnic vessels in three populations and two MRI‐scanners. We found similar agreements with the means for both scanners and for healthy individuals and patients
Lærke S. Gasbjerg, Frederikke H. Østergaard, Rasmus S. Rasmussen, Ludvig S. Langberg, Sophie W. Nielsen, Lotte Alstrup, Tanne S. W. Larsson, Ulrik B. Andersen, Henrik B. W. Larsson, Ali Asmar, Bryan Haddock, Mark B. Vestergaard   +11 more
wiley   +1 more source

On the mechanism of action of glucose-dependent insulinotropic polypeptide

, 1983
The interaction of the intestinal insulinotropic hormone GIP (Glucose-dependent Insulinotropic Polypeptide or Gastric Inhibitory Polypeptide) with the stimulus-secretion coupling mechanism of glucose-induced insulin secretion was investigated using the ...
Dahl, Marshall Andrew
core  

A Review of Lifestyle Interventions Provided as an Adjunct to Obesity Management Medications

Obesity Science &Practice, Volume 12, Issue 4, August 2026.
ABSTRACT Objective This review synthesized the components of lifestyle interventions that have been provided in Phase 3 trials of obesity management medications (OMMs). Methods PubMed, CINAHL, and EMBASE were searched for Phase 3 clinical trials published from inception to February 2026 that tested FDA‐approved OMMs.
Ariana M. Chao, Ransford Asante, Maame Efua Sersah, Umar Anwar Jahangir, Alexandra Peary, Daniel Kudaya   +5 more
wiley   +1 more source

Effects of Subchronic Treatment With the Long-Acting Glucose-Dependent Insulinotropic Polypeptide Receptor Agonist, N-AcGIP, on Glucose Homeostasis in Streptozotocin-Induced Diabetes

, 2007
OBJECTIVES: \ud \ud N-AcGIP is a potent and dipeptidylpeptidase IV-resistant analogue of glucose-dependent insulinotropic polypeptide with significantly improved antidiabetic actions in type 2 diabetes.
McClean, Paula L., Irwin, Nigel, Gault, Victor A., Flatt, Peter R., McCluskey, Jane T., Power, Gavin J., McCluskey, Jane T   +6 more
core   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Weight‐Lowering Drugs and Natural Female Fertility—A Systematic Review and Meta‐Analysis

Clinical Obesity, Volume 16, Issue 4, August 2026.
ABSTRACT Overweight and obesity are global health concerns linked to impaired female fertility. Weight‐lowering drugs are an alternative for achieving weight loss; however, their effect on natural female fertility is unclear. A systematic review and meta‐analysis were conducted to summarise the literature on the effects of weight‐lowering drugs on ...
Shaikha Jabor Alnaimi, Dana Muwafag Alsugeir, Li Wei, Kirsten Harvey, Ruth Brauer   +4 more
wiley   +1 more source

Increased glucose-dependent insulinotropic polypeptide (GIP) secretion in acromegaly

, 2001
Objective: Acromegaly is often associated with fasting and postprandial hyperinsulinemia, and the mechanisms involved are only partly understood. Hypersecretion of incretins such as glucose-dependent insulinotropic polypeptide (GIP) could play a role in ...
C. Gebbia, C. Pagliari, P. Bucciarelli, P. Epaminonda, M. Arosio, S. Manenti, S. Porretti, M. Peracchi   +7 more
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