Results 91 to 100 of about 3,377,134 (229)

Avaliação da expressão do peptídeo insulinotrópico dependente de glicose (GIP) e do seu receptor na medula espinal de animais submetidos ao modelo experimental de lesão medular traumática induzida por compressão [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Médicas, Florianópolis, 2011A lesão traumática da medula espinal (LTME) desencadeia uma síndrome neurológica altamente ...
Marcos, Ana Beatriz Sperb Wanderley
core  

Searching for the physiological role of glucose-dependent insulinotropic polypeptide

, 2016
Glucose-dependent insulinotropic polypeptide (GIP) was established as a gut hormone more than 40 years ago, and there is good experimental support for its role as an incretin hormone although deletion of the GIP receptor or the GIP cells or GIP receptor ...
Hartmann, Bolette, Boer, Geke Aline, Pedersen, Jens, Torekov, Signe, Nissen, Anne, Holst, Jens Juul, Svendsen, Berit, Asmar, Meena, Windeløv, Johanne Agerlin, Christensen, Mikkel   +9 more
core   +1 more source

Amylin Analogs: The Next Major Class of Weight Loss Therapy: A Review of Experimental Data and Early‐Phase Clinical Trials

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims The management of the disease of obesity has been transformed by incretin‐based therapies; however, additional and alternative therapeutic strategies are needed to address its biological complexity. This narrative review examines the physiology of amylin and the emerging role of amylin‐based therapies in obesity management.
Abdulhameed Alhazmi, Carel W. le Roux
wiley   +1 more source

The structure-function relationship of glucose-dependent insulinotropic polypeptide

, 1994
Glucose-dependent insulinotropic polypeptide or gastric inhibitory polypeptide (GIP) is a 42 amino acid endocrine gut hormone which exhibits several direct and indirect effects on fat and glucose metabolism.
Morrow, Glenn Wesley
core   +1 more source

Acute exogenous acyl-GIP treatment enhances lipid handling and fatty acid oxidation by involving brown fat

EMBO Reports
The contribution of glucose-dependent insulinotropic polypeptide receptor (GIPR) signalling in brown adipose tissue (BAT) remains underexplored. We studied the acute effects of exogenous acyl-GIP (1 nmol/kg) administration on whole-body lipid handling ...
Sulayman A Lyons, Micah B S Lea, Mihir Parikh, Zhengzhang Guo, Samrin Kagdi, Abigail R Bisnauth, Jonathan R Pitino, Sabrina Ziai, Negar Mir, Aidan D Tyrrell, Yan Fu, Chuck T Chen, Adam H Metherel, Richard P Bazinet, Bin Yang, Patrick J Knerr, Jonathan D Douros, Jonathan E Campbell, Jacqueline L Beaudry   +18 more
doaj   +1 more source

Glucose-dependent insulinotropic polypeptide may enhance fatty acid re-esterification in subcutaneous abdominal adipose tissue in lean humans

, 2010
Glucose-dependent insulinotropic polypeptide (GIP) has been implicated in lipid metabolism in animals. In humans, however, there is no clear evidence of GIP effecting lipid metabolism.
Sten Madsbad, Stallknecht, Bente Merete, Jens Bülow, Simonsen, Lene, Jens Juul Holst, Meena Asmar, Asmar, Meena, Holst, Jens Juul, Bülow, Jens, Bente Stallknecht, Lene Simonsen, Madsbad, Sten   +11 more
core   +1 more source

Amylin: A Multi‐Functional Pancreatic Hormone—A Review

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Amylin is a pancreatic beta‐cell hormone that sits at a systems hub connecting key aspects of energy metabolism. Amylin physiologically controls satiation, slows gastric emptying and limits postprandial glucagon release, while its actions also link homeostatic eating controls with reward driven behaviours via defined central nervous system ...
Christelle Le Foll, Thomas A. Lutz
wiley   +1 more source

Effects of three different diets on glucose, insulin, triglycerides and glucose-dependent insulinotropic-polypeptide (GIP).

, 2013
Effects of a low-fat diet (open circles, regular lines), low-carbohydrate diet (open squares, dashed lines) and a Mediterranean-type diet (open triangles, dotted lines) with similar total energy intake as the low-fat and low-carbohydrate diets contained ...
Bekim Bunjaku (490259), Christine Jaredsson (490258), Hanna Fernemark (490257), Ulf Rosenqvist (490260), Fredrik H. Nystrom (490261), Hans Guldbrand (490262)   +5 more
core   +1 more source

Retatrutide‐Associated Improvements in Cardiovascular Risk Biomarkers in Adults With Obesity With or Without Type 2 Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To further characterise the effects of retatrutide on cardiometabolic risk, lipoprotein and inflammatory biomarkers were assessed post hoc in phase 2 trials of adults with obesity/overweight with or without type 2 diabetes (T2D). Materials and Methods Data were analysed from two randomised, double‐blind, placebo‐controlled phase 2 trials.
Giacomo Ruotolo, Charles Harris, Yanzhu Lin, Jonathan M. Wilson, Valentina Pirro, Kevin L. Duffin, Melissa K. Thomas, Mark L. Hartman, Ciara O' Neill, Tamer Coskun, Zvonko Milicevic, Axel Haupt, Naveed Sattar, Stephen J. Nicholls   +13 more
wiley   +1 more source

Effect of phenylbutazone administration on the enteroinsular axis in horses with insulin dysregulation

Journal of Veterinary Internal Medicine
Background Phenylbutazone is prescribed for laminitis‐associated pain and decreases glucose and insulin responses to an oral glucose test (OGT) in horses with insulin dysregulation (ID).
Kate L. Kemp, Jazmine E. Skinner, François‐René Bertin   +2 more
doaj   +1 more source