Results 81 to 90 of about 15,165 (218)

Tirzepatide Efficacy and Tolerability According to Early Weight Response: A Post Hoc Analysis of the SURMOUNT‐1 and SURMOUNT‐2 Trials

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Obesity affects over 800 million people globally and is associated with complications including cardiovascular disease and type 2 diabetes (T2D). Early response to weight loss interventions may help optimize achievement of individual treatment goals.
Alexander Kokkinos, Tina Thethi, Clare J. Lee, Lisa M. Neff, Adam Stefanski, Dachuang Cao, Angel Rodriguez, Amy Bartee   +7 more
wiley   +1 more source

Searching for the physiological role of glucose-dependent insulinotropic polypeptide

, 2016
Glucose-dependent insulinotropic polypeptide (GIP) was established as a gut hormone more than 40 years ago, and there is good experimental support for its role as an incretin hormone although deletion of the GIP receptor or the GIP cells or GIP receptor ...
Hartmann, Bolette, Boer, Geke Aline, Pedersen, Jens, Torekov, Signe, Nissen, Anne, Holst, Jens Juul, Svendsen, Berit, Asmar, Meena, Windeløv, Johanne Agerlin, Christensen, Mikkel   +9 more
core   +1 more source

Prescribing Trajectories in Type 2 Diabetes in the United States, 2019–2024

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Importance Clinical guidelines for type 2 diabetes (T2D) provide population‐level recommendations, but real‐world treatment patterns evolve dynamically and vary across patients. Understanding longitudinal prescribing trajectories may reveal heterogeneity in care not captured by cross‐sectional analyses.
Tobias S. Lux, Dongkun Lee, Jeff M. Phillips, Julio C. Facelli, Daniel C. Malone, Matthew Wahl, Deepika Reddy, Farrant Sakaguchi, Ramkiran Gouripeddi, Alexander S. Millar, Matthew J. O'Brien, Joshua S. Choi, Jittrapol Sutejitsiri, Kensaku Kawamoto, Polina V. Kukhareva   +14 more
wiley   +1 more source

Physiological roles of the GIP receptor in murine brown adipose tissue

Molecular Metabolism, 2019
Objective: Glucose-dependent insulinotropic polypeptide (GIP) is secreted from the gut in response to nutrient ingestion and promotes meal-dependent insulin secretion and lipid metabolism.
Jacqueline L. Beaudry, Kiran D. Kaur, Elodie M. Varin, Laurie L. Baggio, Xiemin Cao, Erin E. Mulvihill, Holly E. Bates, Jonathan E. Campbell, Daniel J. Drucker   +8 more
doaj   +1 more source

Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib, Francisco Emilio Fierro, Maria Ortega Abad, Ricardo Correa   +3 more
wiley   +1 more source

The glucose-dependent insulinotropic polypeptide signaling axis in the central nervous system.

, 2019
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone released from the epithelium of the upper small intestine. While GIP shares common actions on the pancreatic beta cell with glucagon-like peptide-1 (GLP-1), unlike GLP-1, GIP ...

core   +1 more source

Loss of Function Glucose-Dependent Insulinotropic Polypeptide Receptor Variants Are Associated With Alterations in BMI, Bone Strength and Cardiovascular Outcomes

, 2021
Glucose-dependent insulinotropic polypeptide (GIP) and its receptor (GIPR) are involved in multiple physiological systems related to glucose metabolism, bone homeostasis and fat deposition.
Hüsün Sheyma Kizilkaya, Gasbjerg, Laerke Smidt, Sparre-Ulrich, Alexander Hovard, Kizilkaya, Hüsün Sheyma, Grarup, Niels, Alexander S. Hauser, Mette M. Rosenkilde, Hauser, Alexander S., Niels Grarup, Kibsgaard, Camilla J., Alexander Hovard Sparre-Ulrich, Sørensen, Kimmie Vestergaard, Rosenkilde, Mette M., Kimmie Vestergaard Sørensen, Camilla J. Kibsgaard, Laerke Smidt Gasbjerg   +15 more
core   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists and Incident Major Adverse Liver Outcomes in People With Type 2 Diabetes and Metabolic Dysfunction‐Associated Steatotic Liver Disease

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Treatment options for metabolic dysfunction‐associated steatotic liver disease (MASLD) are limited. While glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA) and sodium‐glucose cotransporter‐2 (SGLT‐2) inhibitors improve cardiovascular outcomes, comparative effectiveness on liver‐related outcomes remains unclear.
Gregor A. Maier, Ramon A. Hofmann, Michael Roden, Wolfgang Rathmann, Oliver Kuss   +4 more
wiley   +1 more source

Glucose-Dependent Insulinotropic Polypeptide Is Involved in Postprandial Regulation of Splanchnic Blood Supply

Administration of the gut hormone glucose-dependent insulinotropic polypeptide (GIP) increases splanchnic blood flow. We investigated the role of endogenous GIP in splanchnic blood flow regulation using a receptor antagonist in humans.
Hartmann, Bolette, Nielsen, Sophie W., Johannesen, Helle Hjorth, Gasbjerg, Lærke S., Larsson, Henrik B W, Holst, Jens J., Haddock, Bryan, Vestergaard, Mark B., Rasmussen, Rasmus S., Asmar, Ali, Andersen, Ulrik B., Langberg, Ludvig S., Østergaard, Frederikke, Skov-Jeppesen, Kirsa, Rosenkilde, Mette M.   +14 more
core   +1 more source

Neuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer's disease [PDF]

, 2016
Glucose-dependent insulinotropic polypeptide (GIP) is a member of the incretin hormones and growth factors. Neurons express the GIP receptor, and GIP and its agonists can pass through the blood brain barrier and show remarkable neuroprotective effects by
Li, Guanglai, Li, Dongfang, Xue, Guo-Fang, Holscher, Christian, Ji, Chenhui   +4 more
core