Results 71 to 80 of about 15,165 (218)

Dual Glucagon and GLP‐1 Receptor Agonist Survodutide Improves Biomarkers of Beta‐Cell Function and Insulin Sensitivity in People With Type 2 Diabetes or Living With Overweight/Obesity

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims This post hoc analysis evaluated the effect of survodutide on beta‐cell function, insulin sensitivity, and glucose biomarkers in two phase 2 trial populations. Materials and Methods Trial 1404‐0002 randomised 413 participants with type 2 diabetes on metformin to receive survodutide, placebo, or semaglutide over 16 weeks.
Elif I. Ekinci, Sandra González Maldonado, Anna Unseld, Jorge Arrubla Martinez, Anita M. Hennige, Corinna Schoelch   +5 more
wiley   +1 more source

Cloning and Tissue Expression of gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide (GIP) in Pigs

四川大学学报. 自然科学版, 2017
The gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide (GIP) shows the inhibitory effect on gastric acid secretion and incretin action. The aim of this study is to analyze the cDNA sequence of the pig GIP (pGIP) gene, and further
CHENG Shao-Chen, ZHANG Jian-Nan, ZHONG Yu, LI Juan, WANG Ya-Jun   +4 more
doaj  

Tirzepatide for Obesity in Adults ≥ 65 Years: A Post Hoc Analysis of the SURMOUNT and SUMMIT Clinical Trials

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Tirzepatide is a once‐weekly glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonist (RA) approved for weight management in adults with obesity. Data on older adults remain limited, however. This study aimed to examine tirzepatide's safety and efficacy in adults aged ≥ 65 years with obesity ...
Nasreen Alfaris, Robert F. Kushner, Jianghao Li, Kevin L. Chen, Mia Fenimore, Boris Calderon, Adam Stefanski   +6 more
wiley   +1 more source

Glucagon-Like Peptide Receptor-1 Agonists Used for Medically-Supervised Weight Loss in Patients With Hip and Knee Osteoarthritis: Critical Considerations for the Arthroplasty Surgeon

Arthroplasty Today
Patients with morbid obesity and concomitant hip or knee osteoarthritis represent a challenging patient demographic to treat as these patients often present earlier in life, have more severe symptoms, and have worse surgical outcomes following total hip ...
Nathanael D. Heckmann, MD, Ryan Palmer, BS, Cory K. Mayfield, MD, Gligor Gucev, MD, Jay R. Lieberman, MD, Kurt Hong, MD, PhD   +5 more
doaj   +1 more source

Alimentos e nutrientes modulam a libertação de hormonas intestinais anorexígenos.

Acta Médica Portuguesa, 2010
The short-term regulation of food intake controls what, how much and when we eat during one day or a single meal. When ingested, the nutrients produce satiety by means of mechanic stimulation and hormonal release.
Gustavo D Pimentel, Juliane C S Zemdegs
doaj   +1 more source

Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide: new advances

, 2010
This article highlights recent advances in our understanding of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) physiology and their various sites of action beyond the incretin ...
Asmar, Meena, Holst, Jens Juul
core  

Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding

JCI Insight, 2023
Central glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) signaling is critical in GIP-based therapeutics’ ability to lower body weight, but pathways leveraged by GIPR pharmacology in the brain remain incompletely understood. We explored
Alice Adriaenssens, Johannes Broichhagen, Anne de Bray, Julia Ast, Annie Hasib, Ben Jones, Alejandra Tomas, Natalie Figueredo Burgos, Orla Woodward, Jo Lewis, Elisabeth O’Flaherty, Kimberley El, Canqi Cui, Norio Harada, Nobuya Inagaki, Jonathan Campbell, Daniel Brierley, David J. Hodson, Ricardo Samms, Fiona Gribble, Frank Reimann   +20 more
doaj   +1 more source

Effects of Incretin‐Based Therapies, Diet and Exercise Interventions, and Bariatric Surgery on Fat‐Free Mass in Adults With Overweight or Obesity: A Systematic Review and Meta‐Analysis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Maintaining fat‐free mass (FFM) during weight loss is important to maintain a healthy body composition. This review examined changes in FFM during weight loss induced by diet and exercise interventions, incretin‐based therapies, and bariatric surgery, and assessed whether the relative loss of FFM differs by weight‐loss modality ...
Laura Busk‐Cirera, Ida Ørum Carlsen, Lærke Bruun Madsen, Rasmus Michael Sandsdal, Emma Jensen, Simon Birk Kjær Jensen, Signe Sørensen Torekov   +6 more
wiley   +1 more source

Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain

, 2011
The glucose-dependent insulinotropic polypeptide receptor (GIPr) has been implicated in high fat diet-induced obesity and is proposed as an anti-obesity target despite an uncertainty regarding the mechanism of action.
Peter Thams, Pedersen, Jens, Holst, Peter Johannes, Signe Marie Jørgensen, Jens Juul Holst, Holst, Jens Juul, Hanne-Louise Kissow, Rosenkilde, Mette Marie, Füchtbauer, Ernst-Martin, Kissow, Hannelouise, Jørgensen, Signe Marie, Randi Ugleholdt, Steen Seier Poulsen, Nikolaj Nytofte, Ernst-Martin Füchtbauer, Nytofte, Nikolaj, Poulsen, Steen Seier, Jens Pedersen, Yutaka Seino, Bassi, Maria Rosaria, Mette Marie Rosenkilde, Ugleholdt, Randi, Peter Johannes Holst, Thams, Peter, Seino, Yutaka, Maria Rosaria Bassi   +25 more
core   +1 more source

Table_1_Loss of Function Glucose-Dependent Insulinotropic Polypeptide Receptor Variants Are Associated With Alterations in BMI, Bone Strength and Cardiovascular Outcomes.DOCX

, 2021
Glucose-dependent insulinotropic polypeptide (GIP) and its receptor (GIPR) are involved in multiple physiological systems related to glucose metabolism, bone homeostasis and fat deposition.
Laerke Smidt Gasbjerg (11601832), Niels Grarup (154019), Alexander S. Hauser (10984785), Kimmie Vestergaard Sørensen (11601826), Alexander Hovard Sparre-Ulrich (11601835), Mette M. Rosenkilde (205579), Hüsün Sheyma Kizilkaya (11601823), Camilla J. Kibsgaard (11601829)   +7 more
core   +1 more source