Results 101 to 110 of about 3,377,180 (268)

Effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-I-(7-36) on insulin secretion

, 1995
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide (GLP)-I-(7-36) are probably the most important "incretins," but there is controversy as to their relative insulinotropic activities.
J. C. Brown, C. H. McIntosh, X. Jia, P. Ma, R. A. Pederson   +4 more
core   +1 more source

Evaluation of a secondary care multidisciplinary clinic for adults with early‐onset type 2 diabetes at high risk in Leicester, Leicestershire and Rutland

Diabetic Medicine, EarlyView.
Abstract Background Clinical services for adults with early‐onset type 2 diabetes (EOT2D) are in urgent need of improvement. Methods We evaluated a multi‐disciplinary clinic for individuals with EOT2D at high risk (HbA1c >9%/triglyceride >20 mmol/L), providing 2–3 flexibly arranged consultations per individual between March 2024 and September 2025 ...
Jonathan Goldney, Malak Hamza, Priscilla Sarkar, Harriet Morgan, Nicole Green, James Ridgeway, Victoria Alabraba, Laura Willcocks, Krupali Chandracant, Kashmala Javed, Rhys O'Callaghan, Finley Turner, Samuel Seidu, Claire L. Meek, Melanie J. Davies   +14 more
wiley   +1 more source

KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes [PDF]

, 2008
Udgivelsesdato: 2009-FebOBJECTIVE: The reduced incretin effect in subjects with type 2 diabetes is accompanied by a severely impaired insulinotropic effect of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP). The K(ATP) channels of
Volund, A., Kasper Aaboe, Aage Vølund, Jens Juul Holst, Carolyn Fiona Deacon, Holst, Jens Juul, Aaboe, K., Krarup, Thure, Aaboe, Kasper, Sten Madsbad, Knop, K., Thure Krarup, Vølund, Aage, Deacon, Carolyn F., Vilsbøll, Tina, Krarup, T., Tina Vilsboll, Vølund, A, Filip Krag Knop, Simonsen, U, Knop, Filip Krag, Madsbad, S., Simonsen, Ulf, Simonsen, U., Vilsboll, Tina, Deacon, C.F., Vilsboll, T., Madsbad, Sten, Holst, J.J., Ulf Simonsen   +29 more
core   +1 more source

Tirzepatide Persistence and Associated Changes in Clinical Outcomes in US Adults With Obesity or Overweight: A 6‐Month Claims Database Analysis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Tirzepatide is a once‐weekly glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) approved in the US for the treatment of Type 2 diabetes (T2D), weight loss and obstructive sleep apnoea. This study aimed to assess the utilisation and effectiveness of tirzepatide among individuals in a large ...
Theresa Hunter Gibble, Malvika Venkataraman, Donna Mojdami, Carlos Vallarino, Grace Stockbower, Michael Grabner, Mythili Ananth, Karishma Desai   +7 more
wiley   +1 more source

Acute exogenous acyl-GIP treatment enhances lipid handling and fatty acid oxidation by involving brown fat

EMBO Reports
The contribution of glucose-dependent insulinotropic polypeptide receptor (GIPR) signalling in brown adipose tissue (BAT) remains underexplored. We studied the acute effects of exogenous acyl-GIP (1 nmol/kg) administration on whole-body lipid handling ...
Sulayman A Lyons, Micah B S Lea, Mihir Parikh, Zhengzhang Guo, Samrin Kagdi, Abigail R Bisnauth, Jonathan R Pitino, Sabrina Ziai, Negar Mir, Aidan D Tyrrell, Yan Fu, Chuck T Chen, Adam H Metherel, Richard P Bazinet, Bin Yang, Patrick J Knerr, Jonathan D Douros, Jonathan E Campbell, Jacqueline L Beaudry   +18 more
doaj   +1 more source

Avaliação da expressão do peptídeo insulinotrópico dependente de glicose (GIP) e do seu receptor na medula espinal de animais submetidos ao modelo experimental de lesão medular traumática induzida por compressão [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Médicas, Florianópolis, 2011A lesão traumática da medula espinal (LTME) desencadeia uma síndrome neurológica altamente ...
Marcos, Ana Beatriz Sperb Wanderley
core  

Amylin Analogs: The Next Major Class of Weight Loss Therapy: A Review of Experimental Data and Early‐Phase Clinical Trials

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims The management of the disease of obesity has been transformed by incretin‐based therapies; however, additional and alternative therapeutic strategies are needed to address its biological complexity. This narrative review examines the physiology of amylin and the emerging role of amylin‐based therapies in obesity management.
Abdulhameed Alhazmi, Carel W. le Roux
wiley   +1 more source

The structure-function relationship of glucose-dependent insulinotropic polypeptide

, 1994
Glucose-dependent insulinotropic polypeptide or gastric inhibitory polypeptide (GIP) is a 42 amino acid endocrine gut hormone which exhibits several direct and indirect effects on fat and glucose metabolism.
Morrow, Glenn Wesley
core   +1 more source

Glucose-dependent insulinotropic polypeptide may enhance fatty acid re-esterification in subcutaneous abdominal adipose tissue in lean humans

, 2010
Glucose-dependent insulinotropic polypeptide (GIP) has been implicated in lipid metabolism in animals. In humans, however, there is no clear evidence of GIP effecting lipid metabolism.
Sten Madsbad, Stallknecht, Bente Merete, Jens Bülow, Simonsen, Lene, Jens Juul Holst, Meena Asmar, Asmar, Meena, Holst, Jens Juul, Bülow, Jens, Bente Stallknecht, Lene Simonsen, Madsbad, Sten   +11 more
core   +1 more source

Amylin: A Multi‐Functional Pancreatic Hormone—A Review

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Amylin is a pancreatic beta‐cell hormone that sits at a systems hub connecting key aspects of energy metabolism. Amylin physiologically controls satiation, slows gastric emptying and limits postprandial glucagon release, while its actions also link homeostatic eating controls with reward driven behaviours via defined central nervous system ...
Christelle Le Foll, Thomas A. Lutz
wiley   +1 more source