Results 91 to 100 of about 13,497 (214)

Low Weight Loss Response to Incretin Analogs: A Systematic Review

Obesity Reviews, EarlyView.
ABSTRACT The development of GLP‐1 and GIP analogs has been a significant breakthrough in type 2 diabetes and obesity pharmacotherapy. However, individual responses to these medications can vary widely. This systematic review examines factors associated with low or no weight loss response to GLP‐1 and GIP analogs. Key predictors of poor response include
Pamela S. Gaskin, Peter S. Chami
wiley   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Recent clinical and pharmacological advancements of incretin-based therapy and the effects of incretin on physiology

Journal of Diabetology
A novel therapeutic target for diabetes mellitus is incretin-based therapies, glucagon-like peptide-1, and glucose-dependent insulinotropic polypeptides are released from the gastrointestinal (GI) tract and act on beta cells of pancreatic islets by ...
Bhaskar Pal, Moitreyee Chattopadhyay
doaj   +1 more source

Improved Glucagon Sensitivity Following Weight Loss: A Systematic Review and Meta‐Analysis

Obesity Reviews, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis investigated the effect of weight loss in people with obesity on two biomarkers of glucagon resistance: fasting plasma glucagon and alanine. Methods A comprehensive search was conducted in Medline and Embase. Random‐effects meta‐analyses and correlation analyses were performed.
Hye‐Rin Charlotte Kim, Lima Hamidi, Anne Majumdar, Matyas Fehervari, Emma Rose McGlone   +4 more
wiley   +1 more source

Semaglutide versus Tirzepatide - comparison of both drugs in treatment of diabetes type 2 and weight reduction

Quality in Sport
In recent years, the popularity of drugs which were firstly introduced as treatment for diabetes type 2 has surged, because of their’s significant effect of managing the body weight especially for patients that suffer for diabetes type 2.
Arkadiusz Staroń, Patrycja Karkos, Katarzyna Kuśmierczyk, Bartłomiej Gastoł, Karolina Mikołap, Marta Kras, Marta Jurga   +6 more
doaj   +1 more source

Lifestyle modification in atrial fibrillation: Mechanisms, phenotypes and ablation outcomes

Experimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia and is associated with significant morbidity, mortality and healthcare utilization. Catheter ablation is increasingly used as a rhythm‐control intervention for patients with symptomatic paroxysmal and persistent AF, yet recurrence rates remain suboptimal.
Konstantinos Grigoriou, Paschalis Karakasis, Panagiotis Theofilis, Konstantinos Pamporis, Panayotis K. Vlachakis, Anastasios Apostolos, Nikolaos Ktenopoulos, Barbara Fyntanidou, Efstratios Karagiannidis, Dimitrios Patoulias, Antonios P Antoniadis, Nikolaos Fragakis   +11 more
wiley   +1 more source

The Effect of Porcine Orexin a on Glucose-Dependent Insulinotropic Polypeptide Plasma Concentrations in Pigs

European Journal of Inflammation, 2010
The orexigenic system was discovered in 1998. It consists of two neuropeptides, Orexin A and Orexin B. Researchers have focused more on Orexin A, since its intracerebroventricular injection into the lateral ventricle of the rat's brain causes an increase
P. Papakonstantinou, N. Tziris, D. Kapoukranidou, A. Gotzamani-Psarrakou, C.H.R. Tsonidis, M.N. Patsikas, G. Papazoglou   +6 more
doaj   +1 more source

(Dis)agreement and concordance of metabolic indices from the oral glucose tolerance test and mixed‐meal tolerance test: Implications for application

Experimental Physiology, EarlyView.
Abstract Metabolic indices derived from the oral glucose tolerance test (OGTT) and mixed‐meal tolerance test (MMTT) are often interpreted interchangeably; however, these tests represent distinct physiological stimuli. In order to examine potential differential metabolic responses to these tests, we characterized the (dis)agreement between OGTT‐ and ...
Nina Sloth Nielsen, Nikolaj Agerlin, Nikolas Antoniou, Helga Ellingsgaard, Kristian Karstoft, Louise Lang Lehrskov, Grit Elster Legård, Mark Preben Printz Lyngbæk, Beckey Trinh, Thomas P. J. Solomon, Marc Y. Donath, Mathias Ried‐Larsen, Cody Garett Durrer   +12 more
wiley   +1 more source

Reproducibility of Splanchnic Blood Flow Measured Using Phase‐Contrast MRI

NMR in Biomedicine, Volume 39, Issue 8, August 2026.
Splanchnic vessel blood flow assessment can describe physiology or pathophysiological conditions. Here, we assessed the variation of PC‐MRI‐determined repeated measures of blood flow in four splanchnic vessels in three populations and two MRI‐scanners. We found similar agreements with the means for both scanners and for healthy individuals and patients
Lærke S. Gasbjerg, Frederikke H. Østergaard, Rasmus S. Rasmussen, Ludvig S. Langberg, Sophie W. Nielsen, Lotte Alstrup, Tanne S. W. Larsson, Ulrik B. Andersen, Henrik B. W. Larsson, Ali Asmar, Bryan Haddock, Mark B. Vestergaard   +11 more
wiley   +1 more source

A Review of Lifestyle Interventions Provided as an Adjunct to Obesity Management Medications

Obesity Science &Practice, Volume 12, Issue 4, August 2026.
ABSTRACT Objective This review synthesized the components of lifestyle interventions that have been provided in Phase 3 trials of obesity management medications (OMMs). Methods PubMed, CINAHL, and EMBASE were searched for Phase 3 clinical trials published from inception to February 2026 that tested FDA‐approved OMMs.
Ariana M. Chao, Ransford Asante, Maame Efua Sersah, Umar Anwar Jahangir, Alexandra Peary, Daniel Kudaya   +5 more
wiley   +1 more source