Results 81 to 90 of about 3,377,180 (268)

Insulinotropic actions of nateglinide in type 2 diabetic patients and effects on dipeptidyl peptidase-IV activity and glucose-dependent insulinotropic polypeptide degradation

, 2009
Background: Nateglinide restores early-phase insulin secretion to feeding and reduces postprandial hyperglycaemia in type 2 diabetes. This study evaluated the effects of nateglinide on dipeptidyl peptidase-IV (DPP-IV) activity and glucose-dependent ...
McKillop, Aine, Flatt, P.R., Lindsay, John, Bell, Patrick, Patterson, Steven; id_orcid, Patterson, S., Flatt, Peter, O'Harte, F.P.M., McKillop, A.M., Duffy, N.A., Green, Brian, Bell, Patrick M, O'Harte, Finbarr, Duffy, Nicola   +13 more
core   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists for Obstructive Sleep Apnea With and Without Continuous Positive Airway Pressure

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To evaluate glucagon‐like peptide 1 receptor agonists for obstructive sleep apnea compared with controls. Data Sources CINAHL, Cochrane Library, PubMed, and Scopus. Review Methods A PRISMA‐compliant search was conducted from database inception through October 2025.
Cali Loblundo, Sammy Y. Gao, Shaun A. Nguyen, Mohamed Abdelwahab   +3 more
wiley   +1 more source

Male Sexual and Reproductive Health in Diabetes and Obesity Pharmacotherapy: A Source‐Triangulated Counseling Map

Andrology, EarlyView.
ABSTRACT Background Drugs used for diabetes and obesity increasingly shape male sexual and reproductive counseling, but clinical studies, trial registrations, regulatory labels, and patents answer different questions. Objectives The objective is to map these sources and define what each can support when counseling men receiving metabolic drugs ...
Marek Broul, Michal Dubský, Aneta Hujová, Michaela Liegertová   +3 more
wiley   +1 more source

Cloning and Tissue Expression of gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide (GIP) in Pigs

四川大学学报. 自然科学版, 2017
The gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide (GIP) shows the inhibitory effect on gastric acid secretion and incretin action. The aim of this study is to analyze the cDNA sequence of the pig GIP (pGIP) gene, and further
CHENG Shao-Chen, ZHANG Jian-Nan, ZHONG Yu, LI Juan, WANG Ya-Jun   +4 more
doaj  

Alimentos e nutrientes modulam a libertação de hormonas intestinais anorexígenos.

Acta Médica Portuguesa, 2010
The short-term regulation of food intake controls what, how much and when we eat during one day or a single meal. When ingested, the nutrients produce satiety by means of mechanic stimulation and hormonal release.
Gustavo D Pimentel, Juliane C S Zemdegs
doaj   +1 more source

Effects of sitagliptin on blood pressure and heart rate in response to intraduodenal glucose infusion in patients with Type 2 diabetes: a potential role for glucose-dependent insulinotropic polypeptide?

, 2015
Short report: treatmentAIMS: To evaluate the effects of the dipeptidyl peptidase-4 inhibitor sitagliptin on blood pressure and heart rate, measured during a previously reported study, in which the effects of sitagliptin during intraduodenal glucose ...
Bound, MJ, Deacon, C., Horowitz, M., Rayner, CK, Horowitz, M, Trahair, L., Rayner, C., Jones, K., Wu, T., Jones, KL, Bound, M., Deacon, Carolyn F., Wu, T, Trahair, LG   +13 more
core   +1 more source

Review Article: Fibrosis Reversal in Metabolic Dysfunction‐Associated Steatohepatitis—The Promise of Emerging Therapeutics

Alimentary Pharmacology &Therapeutics, EarlyView.
Metabolic dysfunction‐associated steatohepatitis is the second commonest US indication for liver transplantation but remains largely undiagnosed and untreated. Fibrosis stage is the strongest predictor of major adverse liver outcomes, with decompensation rates and transplant‐free survival diverging sharply between F3 and F4, while cardiovascular ...
Malek Ayoub, Tsubasa Tsutsumi, Mary E. Rinella   +2 more
wiley   +1 more source

The level of mendione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion

, 2012
Pancreatic β-cells release insulin in response to elevation of glucose from basal (4–7 mM) to stimulatory (8–16 mM) levels. Metabolism of glucose by the β-cell results in the production of low levels of reactive oxygen intermediates (ROI), such as ...
Womack, Trayce, Gray, Joshua P., Joshua P. Gray, Peter J.S. Smith, Smith, Peter J. S., Meridith Palo, Heart, Emma, Trayce Womack, Emma Heart   +8 more
core   +1 more source

The Glucose-Dependent Insulinotropic Polypeptide Receptor: A Novel Target for Neuroendocrine Tumor Imaging-First Preclinical Studies [PDF]

, 2014
A new family of peptide receptors, the incretin receptor family, overexpressed on many neuroendocrine tumors (NETs) is of great importance because it may enable the in vivo peptide-based receptor targeting of a category of NETs that does not express the ...
Clerc, Pascal, Clerc, P., Gourni, Eleni, Reubi, Jean Claude, Mäcke, Helmut R., Waser, Beatrice, Fourmy, Daniel, Maecke, Helmut R, Reubi, Jean-Claude, Fourmy, D.   +9 more
core   +1 more source

Identification of plasma binding proteins for glucose-dependent insulinotropic polypeptide

Endocrine Journal, 2019
Glucose-dependent insulinotropic polypeptide (GIP), secreted from enteroendocrine K cells, has potent insulin-releasing and extrapancreatic glucoregulatory activities. However, exogenous GIP has less potent biological effects compared with another incretin hormone, GLP-1, which limits its use for the treatment of type 2 diabetes. The fate and secretion
Hoshiyama, Ayako, Fujimoto, Kazumi, Konno, Ryo, Sasaki, Sayaka, Momozono, Akari, Kodera, Yoshio, Shichiri, Masayoshi   +6 more
openaire   +3 more sources