Results 201 to 210 of about 19,271 (221)

Targeting glucose-dependent insulinotropic polypeptide receptor for neurodegenerative disorders

Expert Opinion on Therapeutic Targets, 2018
Incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) exert pleiotropic effects on endocrine pancreas and nervous system. Expression of GIP and GIP receptor (GIPR) in neurons, their roles in neurogenesis, synaptic plasticity, neurotransmission, and neuromodulation uniquely position GIPR for ...
Mahip K. Verma, Rajan Goel, Nandakumar Krishnadas, Kumar V. S. Nemmani   +3 more
openaire   +2 more sources

Glucose-dependent insulinotropic polypeptide and its role in obesity

Current Opinion in Endocrinology, Diabetes & Obesity, 2007
As we strive to improve our understanding of the factors that contribute to the pathogenesis of obesity, it is certainly logical to speculate that a nutrition-dependent component emanating from the gastrointestinal tract, which has the capacity to regulate insulin expression, could represent an etiologic factor in this serious health issue.
Diane H, Song, M Michael, Wolfe
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Glucose-dependent insulinotropic polypeptide – beyond the enteroinsular axis?

Current Opinion in Endocrinology and Diabetes, 2006
Purpose of review: Glucose-dependent insulinotropic polypeptide (GIP) plays an important role in the enteroinsular axis, stimulating insulin secretion. In addition, it has extrapancreatic actions, which may have pathophysiological relevance. This review highlights recent findings with regard to GIP's actions both within the enteroinsular axis and ...
Robertson, MD, Johnston, KL, Morgan, LM
openaire   +2 more sources

Safety of native glucose-dependent insulinotropic polypeptide in humans

Peptides
In this systematic review, we assessed the safety and possible safety events of native glucose-dependent insulinotropic polypeptide (GIP)(1-42) in human studies with administration of synthetic human GIP. We searched the PubMed database for all trials investigating synthetic human GIP(1-42) administration. A total of 67 studies were included.
Helsted, Mads M., Schaltz, Nina L., Gasbjerg, Lærke S., Christensen, Mikkel B., Vilsbøll, Tina, Knop, Filip K.   +5 more
openaire   +3 more sources

Glucose-dependent insulinotropic polypeptide (Gastric Inhibitory Polypeptide; GIP).

Vitamins and hormones, 2009
Glucose-dependent insulinotropic polypeptide (GIP; gastric inhibitory polypeptide) is a 42 amino acid hormone that is produced by enteroendocrine K-cells and released into the circulation in response to nutrient stimulation. Both GIP and glucagon-like peptide-1 (GLP-1) stimulate insulin secretion in a glucose-dependent manner and are thus classified as
Christopher H S, McIntosh, Scott, Widenmaier, Su-Jin, Kim   +2 more
openaire   +1 more source

Differential processing of pro-glucose-dependent insulinotropic polypeptide in gut

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2010
Glucose-dependent insulinotropic polypeptide (GIP) is a hormone released from enteroendocrine K cells in response to meals. Posttranslational processing of the precursor protein pro-GIP at residue 65 by proprotein convertase subtilisin/kexin type 1 (PC1/3) in gut K cells gives rise to the established 42-amino-acid form of GIP (GIP1–42).
Yukihiro, Fujita, Ali, Asadi, Gary K, Yang, Yin Nam, Kwok, Timothy J, Kieffer   +4 more
openaire   +2 more sources

Glucose-dependent insulinotropic polypeptide augmentation of insulin. Physiology or pharmacology?

Diabetes, 1984
Glucose-dependent insulinotropic polypeptide (GIP) is said to be a major physiologic factor in the augmentation of the insulin response to oral glucose. Whether GIP promotes insulin release at physiologic concentrations of glucose or GIP, however, is questionable.
D L, Sarson, S M, Wood, P C, Kansal, S R, Bloom   +3 more
openaire   +2 more sources

Evolution of the vertebrate glucose-dependent insulinotropic polypeptide (GIP) gene

Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2006
The glucose-dependent insulinotropic polypeptide (GIP) gene is believed to have originated from a gene duplication event very early in vertebrate evolution that also produced the proglucagon gene, yet so far GIP has only been described within mammals. Here we report the identification of GIP genes in chicken, frogs, and zebrafish.
David M, Irwin, Tony, Zhang
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Alterations of glucose-dependent insulinotropic polypeptide (GIP) during cold acclimation

Regulatory Peptides, 2011
Cold acclimation is initially associated with shivering thermogenesis in skeletal muscle followed by adaptive non-shivering thermogenesis, particularly in brown adipose tissue (BAT). In response, hyperphagia occurs to meet increased metabolic demand and thermoregulation.
N, Irwin, J M E, Francis, P R, Flatt
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Clinical endocrinology and metabolism. Glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide.

Best practice & research. Clinical endocrinology & metabolism, 2005
The 42 amino acid polypeptide glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide (GIP) is released from intestinal K-cells in response to nutrient ingestion. Based on animal studies, the peptide was initially assumed to act as an endogenous inhibitor of gastric acid secretion.
Juris J, Meier, Michael A, Nauck
openaire   +1 more source