Results 91 to 100 of about 3,223,897 (362)

Protein-centric omics analysis reveals circulating complements linked to non-viral liver diseases as potential therapeutic targets [PDF]

Clinical and Molecular Hepatology
Background/Aims To evaluate the causal correlation between complement components and non-viral liver diseases and their potential use as druggable targets.
Yingzhou Shi, Hang Dong, Shiwei Sun, Xiaoqin Wu, Jiansong Fang, Jianbo Zhao, Junming Han, Zongyue Li, Huixiao Wu, Luna Liu, Wanhong Wu, Yang Tian, Guandou Yuan, Xiude Fan, Chao Xu   +14 more
doaj   +1 more source

A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells. [PDF]

, 2019
Elevated glucose consumption is fundamental to cancer, but selectively targeting this pathway is challenging. We develop a high-throughput assay for measuring glucose consumption and use it to screen non-small-cell lung cancer cell lines against ...
Chen, Bao Ying, Clark, Peter M, Damoiseaux, Robert, Ghezzi, Chiara, Ribalet, Bernard, Wong, Alicia   +5 more
core   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Development and application of a self-referencing glucose microsensor for the measurement of glucose consumption by pancreatic ?-cells

, 2001
Glucose gradients generated by an artificial source and ?-cells were measured using an enzyme-based glucose microsensor, 8-?m tip diameter, as a self-referencing electrode.
Jung, Sung-Kwon, Sanger, Richard H., Smith, Peter J. S., Trimarchi, James R.   +3 more
core   +1 more source

Construction of hyperthermostable d‐allulose 3‐epimerase from Arthrobacter globiformis M30 using the sequence information from Arthrobacter psychrolactophilus

FEBS Open Bio, EarlyView.
d‐Allulose can be produced from d‐fructose by d‐allulose 3‐epimerase. Based on sequence homology information, we successfully engineered thermostable mutants with the protein engineering method. By integrating positive mutations, we constructed an enzyme that exhibits hyperthermostability without a loss in the activity.
Kensaku Shimada, Kouhei Ohtani, Pushpa Kiran Gullapalli, Kazuhiko Ishikawa   +3 more
wiley   +1 more source

Association of the triglyceride glucose-waist height ratio with asymptomatic intracranial arterial stenosis

Lipids in Health and Disease
Background and objective This study evaluated the associations of the triglyceride-glucose (TyG) index or its attendant parameters, known as reliable measures of insulin resistance, with asymptomatic intracranial arterial stenosis (aICAS), along with ...
Yumeng Yang, Liying Guo, Shiqing Song, Xianglong Kong, Yuanyuan Zhao, Xiaotong Ma, Xiang Wang, Hailing Wang, Qinjian Sun   +8 more
doaj   +1 more source

Cognitive impairment and amygdala subregion volumes in elderly with cerebral small vessel disease: A large prospective cohort study

Neurobiology of Disease
Although the amygdala is associated with cognitive impairment resulting from cerebral small vessel disease, the relationship between alterations in amygdala structure and cerebral small vessel disease (CSVD) remains controversial. Given that the amygdala
Zhenyu Cheng, Linfeng Yang, Jing Li, Yiwen Chen, Pengcheng Liang, Yuanyuan Wang, Na Wang, Xinyue Zhang, Yian Gao, Chaofan Sui, Meng Li, Changhu Liang, Lingfei Guo   +12 more
doaj   +1 more source

Mortality Salience and Metabolism: Glucose Drinks Reduce Worldview Defense Caused by Mortality Salience [PDF]

, 2012
The current work tested the hypothesis that a glucose drink would reduce worldview defense following mortality salience. Participants consumed either a glucose drink or placebo, wrote about either death or dental pain, and then completed a measure of ...
Gailliot, Matthew T.
core   +2 more sources

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

The effect of exogenous glucose infusion on early embryonic development in lactating dairy cows [PDF]

, 2018
peer-reviewedThe objective of this study was to examine the effect of intravenous infusion of glucose on early embryonic development in lactating dairy cows. Nonpregnant, lactating dairy cows (n = 12) were enrolled in the study (276 ± 17 d in milk). On d
Butler, Stephen, Curran, F., Forde, Niamh, Herlihy, Mary M., Kenneally, J., Leane, S., Lonergan, P., Lucy, Matt C., Simintiras, Constantine A., Sturmey, Roger G.   +9 more
core   +2 more sources