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Islets and Glucose Homeostasis [PDF]
Diabetes mellitus is a chronic progressive metabolic disease, resulting from both insulin resistance and the dysfunction of beta-cells. Beta-cell apoptosis is a crucial pathophysiology leading to diabetes [1]. Aberrant immune system leads to destroying of beta-cells occurring in type 1 diabetes. Infiltration of immune cells around beta-cells and attack
Tien-Jyun Chang+2 more
doaj +4 more sources
Editorial: Epigenetics of Glucose Homeostasis
Senta Georgia+3 more
doaj +3 more sources
Elevated Paracellular Glucose Flux across Cystic Fibrosis Airway Epithelial Monolayers Is an Important Factor for Pseudomonas aeruginosa Growth. [PDF]
People with cystic fibrosis (CF) who develop related diabetes (CFRD) have accelerated pulmonary decline, increased infection with antibiotic-resistant Pseudomonas aeruginosa and increased pulmonary exacerbations.
AA Pezzulo+37 more
core +15 more sources
Magnesium and glucose homeostasis [PDF]
Magnesium is an important ion in all living cells being a cofactor of many enzymes, especially those utilising high energy phosphate bounds. The relationship between insulin and magnesium has been recently studied. In particular it has been shown that magnesium plays the role of a second messenger for insulin action; on the other hand, insulin itself ...
PAOLISSO, Giuseppe+3 more
openaire +4 more sources
Anchored phosphatases modulate glucose homeostasis. [PDF]
Endocrine release of insulin principally controls glucose homeostasis. Nutrient-induced exocytosis of insulin granules from pancreatic β-cells involves ion channels and mobilization of Ca(2+) and cyclic AMP (cAMP) signalling pathways.
Cirulli, Vincenzo+12 more
core +1 more source
Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight [PDF]
Despite clear associations between vitamin D deficiency and obesity and/or type 2 diabetes, a causal relationship is not established. Vitamin D receptors (VDRs) are found within multiple tissues, including the brain.
Arble, Deanna M.+9 more
core +4 more sources
Testosterone insulin-like effects: an in vitro study on the short-term metabolic effects of testosterone in human skeletal muscle cells [PDF]
Testosterone by promoting different metabolic pathways contributes to short-term homeostasis of skeletal muscle, the largest insulin-sensitive tissue and the primary site for insulin-stimulated glucose utilization.
Antinozzi, Cristina+8 more
core +2 more sources
The role of insulin receptor substrate 2 in hypothalamic and β cell function [PDF]
Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in β cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons ...
Al-Qassab, H.+39 more
core +4 more sources
Bile acids during pregnancy: Trimester variations and associations with glucose homeostasis
Background and aims Bile acids are known to contribute to hepatic glucose and lipid metabolism regulation. Although glucose homeostasis sustains well‐characterized modifications during uncomplicated pregnancies, changes in bile acids concentrations and ...
Marianne Gagnon+6 more
doaj +1 more source