Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice. [PDF]
, 1975 SummaryHypothalamic ribosomal S6K1 has been suggested as a point of convergence for hormonal and nutrient signals in the regulation of feeding behavior, bodyweight, and glucose metabolism.
Smith, MA +11 more
core +9 more sources
Antidiabetic effect of Tibetan medicine Tang-Kang-Fu-San in db/db mice via activation of PI3K/Akt and AMPK pathways [PDF]
, 2017 This study was to investigate the anti-diabetic effects and molecular mechanisms of Tang-Kang-Fu-San (TKFS), a traditional Tibetan medicine, in treating type 2 diabetes mellitus of spontaneous diabetic db/db mice.
Bailu Duan +8 more
core +3 more sources
Links between Thyroid Disorders and Glucose Homeostasis [PDF]
Diabetes & Metabolism Journal, 2022 Thyroid disorders and diabetes mellitus often coexist and are closely related. Several studies have shown a higher prevalence of thyroid disorders in patients with diabetes mellitus and vice versa. Thyroid hormone affects glucose homeostasis by impacting
Young Sil Eom +2 more
doaj +1 more source
mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue [PDF]
, 2016 Activation of non-shivering thermogenesis (NST) in brown adipose tissue (BAT) has been proposed as an anti-obesity treatment. Moreover, cold-induced glucose uptake could normalize blood glucose levels in insulin-resistant patients.
Albert V +12 more
core +4 more sources
An investigation of acute effects at various doses of malathion on glucose homeostasis and insulin resistance in rat liver, pancreas and serum [PDF]
, 2020 Objective. This study investigates acute effects of various doses of Malathion on glucose homeostasis and insulin resistance in rat. Methods. Rats were randomly divided into four groups of 6 animals each. Corn oil was given orally to Group 1.
Ekremoğlu, Murat +4 more
core +3 more sources
Glucose tolerance and weight loss in obese women with obstructive sleep apnea. [PDF]
PLoS ONE, 2013 BACKGROUND: The association of obstructive sleep apnea (OSA) with glucose intolerance and the beneficial effect of lifestyle intervention have been poorly investigated in women particularly before menopausal status.
Luisa Gilardini +7 more
doaj +1 more source
A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response. [PDF]
, 2017 Insulin production by the pancreatic β-cell is required for normal glucose homeostasis. While key transcription factors that bind to the insulin promoter are known, relatively little is known about the upstream regulators of insulin transcription.
Ang, Kenny +12 more
core +1 more source
Glycemia Regulation: From Feedback Loops to Organizational Closure. [PDF]
, 2020 Endocrinologists apply the idea of feedback loops to explain how hormones regulate certain bodily functions such as glucose metabolism. In particular, feedback loops focus on the maintenance of the plasma concentrations of glucose within a narrow range ...
Bich, Leonardo +2 more
core +4 more sources
Ablation of ghrelin O-acyltransferase does not improve glucose intolerance or body adiposity in mice on a leptin-deficient ob/ob background. [PDF]
PLoS ONE, 2013 Type 2 Diabetes is a global health burden and based on current estimates will become an even larger problem in the future. Developing new strategies to prevent and treat diabetes is a scientific challenge of high priority. The stomach hormone ghrelin has
Henriette Kirchner +5 more
doaj +1 more source
The Interaction of Insulin and Pituitary Hormone Syndromes
Frontiers in Endocrinology, 2021 Pituitary hormone axes modulate glucose metabolism and exert direct or indirect effects on insulin secretion and function. Cortisol and growth hormone are potent insulin-antagonistic hormones.
Marie Helene Schernthaner-Reiter +3 more
doaj +1 more source