Results 91 to 100 of about 181,335 (186)

[18F]FDG-PET and [18F]MPPF-PET are brain biomarkers for the creatine transporter Slc6a8 loss of function mutation

open access: yesScientific Reports
Pathogenic variants in the creatine transporter gene SLC6A8, reported to represent 2% of all intellectual disabilities in males, result in a spectrum of behavioral abnormalities including developmental delay, intellectual disability, and deficit in ...
Isabel Day   +8 more
doaj   +1 more source

Chenodeoxycholic Acid Ameliorates AlCl3-Induced Alzheimer’s Disease Neurotoxicity and Cognitive Deterioration via Enhanced Insulin Signaling in Rats

open access: yes, 2019
Insulin resistance is a major risk factor for Alzheimer’s disease (AD). Chenodeoxycholic acid (CDCA) and synthetic Farnesoid X receptor (FXR) ligands have shown promising outcomes in ameliorating insulin resistance associated with various medical ...
Firas H. Bazzari   +5 more
core   +1 more source

Spatial memory impairment is associated with hippocampal insulin signals in ovariectomized rats.

open access: yes, 2014
Estrogen influences memory formation and insulin sensitivity. Meanwhile, glucose utilization directly affects learning and memory, which are modulated by insulin signals.
De-Gui Wang   +7 more
core   +1 more source

Therapeutic health effects of ginger (Zingiber officinale): updated narrative review exploring the mechanisms of action

open access: yes, 2023
Ginger (Zingiber officinale) has been investigated for its potentially therapeutic effect on a range of chronic conditions and symptoms in humans. However, a simplified and easily understandable examination of the mechanisms behind these effects is ...
Skye Marshall (5424758)   +4 more
core  

Effectiveness of Kelakai (Stenochlaena palustris (Burm.) Bedd) Extract as an Anti-diabetic through Increased GLUT 4 Expression without Affecting Insulin Levels

open access: yesJournal of Health Science and Medical Research (JHSMR)
Objective: Untreated hyperglycemia disrupts insulin secretion and blocks glucose transporter 4 (GLUT 4), consequently affecting the glucose levels of patients with type 2 diabetes mellitus.
Kiki Rizky Ananda   +2 more
doaj   +1 more source

Herbal informatics approach for the selection of natural compounds targeting diabetes mellitus [PDF]

open access: yes, 2018
270-275Diabetes mellitus is a chronic metabolic disorder where the Beta-cells present on the islets of Langerhans of pancreas fail to produce enough insulin resulting in unstable blood glucose level that pave the way for insulin resistance by tissues ...
Zaidi, Ayesha Ali   +13 more
core  

Mechanism of FoxO1 in the Metabolic Shift of Fetal Rat Heart

open access: yesMolecules
Cardiovascular diseases remain a leading cause of morbidity and mortality worldwide, underscoring the need to better understand cardiovascular physiology. A key aspect involves identifying regulatory molecules that govern metabolic shifts.
William William   +5 more
doaj   +1 more source

분화된 인간 근육 세포에서 Musclin이 인슐린과 다른 경로를 통해 포도당 섭취에 미치는 효과 검증

open access: yes, 2022
Exercise is considered as the most effective therapeutic strategy in the improvement of metabolic diseases. Skeletal muscle is involved in the homeostasis of energy metabolism via its secretory proteins known as myokines, thereby (skeletal muscle is ...
조소연
core  

Abrus precatorius Leaf Extract Stimulates Insulin-mediated Muscle Glucose Uptake: In vitro Studies and Phytochemical Analysis

open access: yes
Diabetes mellitus, linked with insulin resistance and hyperglycaemia, is a leading cause of mortality. Glucose uptake through glucose transporter type 4, especially in skeletal muscle, is crucial for maintaining euglycaemia and is a key pathway targeted ...
Dan Dias (14681695)   +2 more
core  

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