Fermentation, 2023 The purpose of this study was to investigate the effects of replacing a portion of whole-plant corn silage with straw on the rumen microbial community structure and carbohydrate-active enzyme activity.
Yubin Ma +6 more
doaj +1 more source
Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells. [PDF]
, 2014 Gaucher disease is caused by mutations in the glucocerebrosidase gene, which encodes the lysosomal hydrolase glucosylceramidase. Patients with Gaucher disease and heterozygous glucocerebrosidase mutation carriers are at increased risk of developing ...
Abramov, AY +10 more
core +1 more source
Sphingolipid Distribution, Content and Gene Expression during Olive-Fruit Development and Ripening
Frontiers in Plant Science, 2018 Plant sphingolipids are involved in the building of the matrix of cell membranes and in signaling pathways of physiological processes and environmental responses.
Carla Inês +7 more
doaj +1 more source
Evolution of substrate-specific gene expression and RNA editing in brown rot wood-decaying fungi. [PDF]
, 2019 Fungi that decay wood have characteristic associations with certain tree species, but the mechanistic bases for these associations are poorly understood.
Ahrendt, Steven +10 more
core +1 more source
Novel homozygous GBA2 mutation in a patient with complicated spastic paraplegia [PDF]
, 2018 Hereditary spastic paraplegias (HSPs) are a heterogeneous group of neurological disorders characterized primarily by a pyramidal syndrome with lower limb spasticity, which can manifest as pure HSP or associated with a number of neurological or non ...
Bertini, Enrico +10 more
core +1 more source
Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes [PDF]
, 2016 The development of small molecule activity-based probes (ABPs) is an evolving and powerful area of chemistry. There is a major need for synthetically accessible and specific ABPs to advance our understanding of enzymes in health and disease.
Aerts, Johannes M F G +12 more
core +11 more sources
Effects of ADMA upon gene expression: An insight into the pathophysiological significance of raised plasma ADMA [PDF]
, 2005 Background Asymmetric dimethylarginine (ADMA) is a naturally occurring inhibitor of nitric oxide synthesis that accumulates in a wide range of diseases associated with endothelial dysfunction and enhanced atherosclerosis.
Achan +41 more
core +5 more sources
Glucosylceramidases and malignancies in mammals
Biochimie, 2016 Sphingolipids represent a major class of lipids that are essential constituents of eukaryotic cells. They are predominantly located in plasma membrane microdomains, and play an important structural role in regulating membrane fluidity. They are also bioactive effectors involved in diverse key cellular functions such as apoptosis and proliferation.
Astudillo, Leonardo +5 more
openaire +3 more sources
Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease. [PDF]
PLoS ONE, 2011 The neuropathic glycosphingolipidoses are a subgroup of lysosomal storage disorders for which there are no effective therapies. A potential approach is substrate reduction therapy using inhibitors of glucosylceramide synthase (GCS) to decrease the ...
Karen M Ashe +12 more
doaj +1 more source
Biomedicines, 2022 Exosomes/microvesicles originate from multivesicular bodies that allow the secretion of endolysosome components out of the cell. In the present work, we investigated the effects of rottlerin, a polyphenol, on exosome/microvesicle secretion in a model of ...
Yessenia L. Molina +10 more
doaj +1 more source