Results 131 to 140 of about 9,362 (180)
Sinbaglustat is efficacious in GM2 gangliosidosis primarily through inhibition of GBA2 rather than GCS. [PDF]
Mol Ther AdvSteiner MA +8 more
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The Involvement of Ceramide, Sphingosine-1-Phosphate and Ganglioside GM1 in Regulating Some Nervous System Functions. [PDF]
Int J Mol SciGiussani P, Mauri L, Sonnino S.
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The Role of Glycosphingolipids in Autoimmune Manifestations and Myeloma in Gaucher Disease
Pavlova E +5 more
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Glucosylceramide synthase and apoptosis
Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2002Glucosylceramide synthase (GCS) is an enzyme inherent to ceramide metabolism. The enzyme catalyzes the transfer of glucose to ceramide, the first committed step in glycolipid biosynthesis. Known for many years as a branch point enzyme directing synthesis of cerebrosides and gangliosides, GCS has recently been implicated in the cytotoxic response of ...
Myles C Cabot
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Glucosylceramide synthase and glycosphingolipid synthesis
Trends in Cell Biology, 1998In mammalian cells, there are two major classes of sphingolipids---sphingomyelin and glycosphingolipids (GSLs)--both of which are synthesized from the hydrophobic molecule ceramide. The synthesis of most GSLs begins with glucosylation of ceramide to form glucosylceramide (GlcCer), which, in turn, serves as the source of 300-400 GSLs.
Yoshio Hirabayashi, Shinichi Ichikawa
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Inhibitors of Glucosylceramide Synthase
2023Glucosylceramide synthase can be targeted by high affinity small molecular weight inhibitors for the study of glycosphingolipid metabolism and function or for the treatment of glycosphingolipid storage disorders, including Gaucher and Fabry disease. This work is exemplified by the discovery and development of eliglustat tartrate, the first stand-alone ...
James A, Shayman +2 more
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Immunogenic properties of glucosylceramide
Molecular Immunology, 1979Abstract Specific antibodies against glucosylceramide were elicited in rabbits by repeated intravenous injection of a mixture of hapten-cholesterol-human albumin (0.2:1:4) (mg/ml). The antisera obtained were titrated both by complement fixation and by passive agglutination.
B, Zalc +3 more
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2010
Glucosylceramide has a unique and often ambiguous role in mammalian cells. Activation of glucosylceramide synthase, the enzyme that places a glucosyl moiety onto ceramide, is the first pathway-committed step to the production of more complex glycosphingolipids such as lactosylceramide and gangliosides.
Maria C, Messner, Myles C, Cabot
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Glucosylceramide has a unique and often ambiguous role in mammalian cells. Activation of glucosylceramide synthase, the enzyme that places a glucosyl moiety onto ceramide, is the first pathway-committed step to the production of more complex glycosphingolipids such as lactosylceramide and gangliosides.
Maria C, Messner, Myles C, Cabot
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