Results 141 to 150 of about 9,362 (180)

Tumor specific cytotoxicity of glucosylceramide

Cancer Chemotherapy and Pharmacology, 2007
To develop a new taxon of anti-cancer agent with lower side effect, this study described a tumor selective cytotoxicity of glucosylceramide extracted from malt feed of beer brewing waste. Interpretation of (13)C- and (1)H-NMR spectra identified the chemical structure of major component of glucosylceramide as 1-O-beta-D: -glucopyranosyl-2(2 ...
Hirosuke, Oku, Sawitree, Wongtangtintharn, Hironori, Iwasaki, Masashi, Inafuku, Masayuki, Shimatani, Takayoshi, Toda   +5 more
openaire   +2 more sources

Compartmentation and topology of glucosylceramide synthesis

Biochemical Society Transactions, 2000
Evidence is presented supporting a model for glucosylceramide formation on the apoplastic side of the plasma membrane in plants. Glucosylceramide synthase and sterol glucosyltransferase were both localized to the plasma membrane. Whereas sterol glucosylation was sensitive to proteolytic enzymes, ceramide glucosylation was not.
J L, Cantatore, S M, Murphy, D V, Lynch
openaire   +2 more sources

GBA mutations, glucosylceramide and Parkinson's disease

Current Opinion in Neurobiology, 2022
Mutations in GBA, which encodes the lysosomal enzyme glucocerebrosidase, are the highest genetic risk factor for Parkinson's disease (PD), although the mechanistic link between GBA mutations and PD is unknown. An attractive hypothesis is that the lipid substrate of glucocerebrosidase, glucosylceramide, accumulates in patients with PD with a GBA ...
Ivan Milenkovic, Shani Blumenreich, Anthony H. Futerman   +2 more
openaire   +2 more sources

Changes in Ceramides and Glucosylceramides in Mouse Skin and Human Epidermal Equivalents by Rice-Derived Glucosylceramide

Journal of Medicinal Food, 2012
Ceramides (Cer) and glucosylceramides (GlcCer) play an important role in moisturizing the epidermis. Dietary GlcCer has been reported to improve transepidermal water loss (TEWL). However, the effect of GlcCer on epidermal Cer and GlcCer has not been well established.
Hiroshi, Shimoda, Shuko, Terazawa, Shoketsu, Hitoe, Junji, Tanaka, Seikou, Nakamura, Hisashi, Matsuda, Masayuki, Yoshikawa   +6 more
openaire   +2 more sources

Discovery and Characterization of an Inhibitor of Glucosylceramide Synthase

Journal of Medicinal Chemistry, 2012
Targeting glycosphingolipid synthesis has emerged as a novel approach for treating metabolic diseases. 32 (EXEL-0346) represents a new class of glucosylceramide synthase (GCS) inhibitors. This report details the elaboration of hit 8 with the goal of achieving and maintaining maximum GCS inhibition in vivo.
Steven, Richards, Christopher J, Larson, Elena S, Koltun, Art, Hanel, Vicky, Chan, Jason, Nachtigall, Amanda, Harrison, Naing, Aay, Hongwang, Du, Arlyn, Arcalas, Adam, Galan, Jeff, Zhang, Wentao, Zhang, Kwang-Ai, Won, Danny, Tam, Fawn, Qian, Tao, Wang, Patricia, Finn, Kathy, Ogilvie, Jon, Rosen, Ron, Aoyama, Artur, Plonowski, Belinda, Cancilla, Frauke, Bentzien, Michael, Yakes, Raju, Mohan, Peter, Lamb, John, Nuss, Patrick, Kearney   +28 more
openaire   +2 more sources

Development of a New Inhibitor of Glucosylceramide Synthase

Journal of Biochemistry, 2000
Analogs of the potent inhibitor of glucosylceramide (GlcCer) synthase, D-threo-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (P4), based on substitutions in the palmitoyl group were made by means of a stereo-selective synthetic method in order to elucidate the role of the hydrophobic portion in both the inhibitory action toward the enzyme and the ...
M, Jimbo, K, Yamagishi, T, Yamaki, K, Nunomura, K, Kabayama, Y, Igarashi, J I, Inokuchi   +6 more
openaire   +2 more sources

Glucosylceramide and Galactosylceramide Synthase

2006
Most mammalian glycosphingolipid formation begins with the synthesis of cerebrosides, glucosylceramide and galactosylceramide. The synthases catalyzing the formations of glucosylceramide (GlcCer) and galactosylceramide (GalCer) have been characterized at the gene and protein levels.
openaire   +1 more source

Dietary Fungal Glucosylceramide and Ceramide Reduce the Formation of Aberrant Crypt Foci in 1,2-Dimethylhydrazine-Treated Mice: Differences in the Role of Glucosylceramide and Ceramide

ACS Food Science & Technology, 2023
Kazuo Miyashita, Shinji Yamashita, Jinichiro Koga   +2 more
exaly  

Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models

Proceedings of the National Academy of Sciences of the United States of America, 2017
S Pablo Sardi, John Marshall, Richard Sidman   +2 more
exaly  

Inhibitory Effect of Topical Maize Glucosylceramide on Skin Photoaging in UVA-irradiated Hairless Mice

Journal of Oleo Science, 2011
Tatsuya Sugawara, Eriko Shimada, Takashi Hirata   +2 more
exaly