Results 61 to 70 of about 56,016 (216)

Canned Foods: Evolution, Benefits, and Health Implications of Modern Packaging

Food Safety and Health, EarlyView.
This graphical abstract presents a concise visual overview of canned food technology, highlighting its historical evolution, key benefits, and associated health risks. It integrates timelines, icons, and summary points to clearly communicate advancements in preservation, consumer advantages, and potential safety concerns in a single schematic ...
Shaswati Rout, Priyadarsini Sahoo, Anuprita Ray, Shuvendu Shekhar Mohapatra   +3 more
wiley   +1 more source

Androgen Glucuronidation in Mice: When, Where, and How

Biology, 2022
Glucuronidation, catalyzed by UDP-glucuronosyltransferase UGT2B enzymes, is a major inactivating and elimination pathway for androgen hormones in humans.
Laurent Grosse, Sarah Chouinard, Sophie Pâquet, Mélanie Verreault, Jocelyn Trottier, Alain Bélanger, Olivier Barbier   +6 more
doaj   +1 more source

UDP-glucuronosyltransferases in sickness and health : Studies on bilirubin and steroid glucuronidation [PDF]

, 2013
UDP-glucuronosyltransferases (UGTs) are responsible for the metabolism of many xenobiotics, as well as several endogenous compounds like bilirubin and certain steroids.
Sneitz, Nina
core  

Read-across of 90-Day Rat Oral Repeated-Dose Toxicity: A Case Study for Selected 2-Alkyl-1-alkanols [PDF]

, 2017
2-Alkyl-1-alkanols offer an example whereby the category approach to read-across can be used to predict repeated-dose toxicity for a variety of derivatives.
Bradbury, S.P, Cronin, M.T.D, Mellor, Claire, Przybylak, P.R, Richardz, A-N, Schultz, T.W   +5 more
core   +3 more sources

UGT1A1 Fragment Analysis: Genotyping the (TA)n Variable Repeat Polymorphism for Clinical Applications

Journal of Clinical Laboratory Analysis, EarlyView.
This study developed a PCR‐based fragment analysis assay for UGT1A1 rs3064744 targeting TA5 (*36), TA6 (*1), TA7 (*28), and TA8 (*37). The assay was CLIA validated with data showing 100% concordance and a sensitivity of 0.5 ng/uL. The assay was then implemented in a patient cohort of n = 940 and the results compared with PharmacoScan.
Ryan N. Baugher, Kristen M. Pike, Teri M. Plona, Stephanie D. Mellott, Todd B. Young, Heidi E. Lawhorn, Stephen M. Hewitt   +6 more
wiley   +1 more source

The Efflux Mechanism of Fraxetin-O-Glucuronides in UGT1A9-Transfected HeLa Cells: Identification of Multidrug Resistance-Associated Proteins 3 and 4 (MRP3/4) as the Important Contributors

Frontiers in Pharmacology, 2019
Fraxetin, a natural compound present in many dietary supplements and herbs, is useful in the treatment of acute bacillary dysentery and type 2 diabetes. Previously, several metabolic studies have revealed extensive first-pass metabolism causing formation
Zifei Qin, Zifei Qin, Beibei Zhang, Beibei Zhang, Jing Yang, Jing Yang, Shishi Li, Jinjin Xu, Zhihong Yao, Zhihong Yao, Xiaojian Zhang, Xiaojian Zhang, Frank J. Gonzalez, Xinsheng Yao, Xinsheng Yao   +14 more
doaj   +1 more source

Metabolism and disposition of opicapone in the rat and metabolic enzymes phenotyping

Pharmacology Research & Perspectives, 2022
Opicapone (2,5‐dichloro‐3‐(5‐(3,4‐dihydroxy‐5‐nitrophenyl)‐1,2,4‐oxadiazol‐3‐yl)‐4,6‐dimethylpyridine 1‐oxide) is a selective catechol‐O‐methyltransferase inhibitor that has been granted marketing authorization in Europe, Japan, and United States.
Ana I. Loureiro, Carlos Fernandes‐Lopes, Maria João Bonifácio, Filipa Sousa, László E. Kiss, Patricio Soares‐da‐Silva   +5 more
doaj   +1 more source

Detection and quantification of codeine-6-glucuronide, hydromorphone-3-glucuronide, oxymorphone-3-glucuronide, morphine 3-glucuronide and morphine-6-glucuronide in human hair from opioid users by LC–MS-MS [PDF]

Journal of Analytical Toxicology, 2017
Current hair testing methods that rely solely on quantification of parent drug compounds are unable to definitively distinguish between drug use and external contamination. One possible solution to this problem is to confirm the presence of unique drug metabolites that cannot be present through contamination, such as phase II glucuronide conjugates ...
Megan, Grabenauer, Nichole D, Bynum, Katherine N, Moore, Robert M, White, John M, Mitchell, Eugene D, Hayes, Ronald, Flegel   +6 more
openaire   +2 more sources

Liver X Receptor α (LXRα) Regulates 5β‐Reductase (AKR1D1) Expression in Avian Embryos: Implications for Yolk Steroid Metabolism

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Steroid‐mediated maternal effects are well‐studied as a source of phenotypic variation. In bird eggs, the yolk contains various steroids that can influence embryonic development. However, one complicating factor in understanding how yolk steroids affect development is that the embryo metabolizes yolk steroids to regulate exposure.
Ryan T. Paitz, Sara E. Waters, Delaney K. Reynolds, Emily M. Drew, Emily P. Harders   +4 more
wiley   +1 more source

Inactivation of Prostaglandin E2 as a Mechanism for UGT2B17-Mediated Adverse Effects in Chronic Lymphocytic Leukemia

Frontiers in Oncology, 2019
High expression of the metabolic enzyme UDP-glucuronosyltransferase UGT2B17 in chronic lymphocytic leukemia (CLL) cells was associated with poor prognosis in two independent studies. However, the underlying mechanism remains unknown. We hypothesized that
Eric P. Allain, Michèle Rouleau, Trang Le, Katrina Vanura, Lyne Villeneuve, Patrick Caron, Véronique Turcotte, Eric Lévesque, Chantal Guillemette, Chantal Guillemette   +9 more
doaj   +1 more source