Results 141 to 150 of about 33,429 (298)

Characterization of fecal deglucuronidation activity in healthy subjects and in patients treated with fecal microbiota transplantation. [PDF]

Drug Metab Dispos
Uoti A, Neulasalmi O, Hiippala K, Oksanen T, Arkkila P, Puustinen L, Satokari R, Sjöstedt N.   +7 more
europepmc   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, Volume 13, Issue 44, 7 August 2026.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Role of metabolites in drug-drug interactions. [PDF]

Drug Metab Pharmacokinet
Isoherranen N.
europepmc   +1 more source

Heterojunction‐Engineered Mass Spectrometry Platform for Deciphering Serum Metabolic Fingerprints in Diagnosis of Respiratory Diseases

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Hollow Co3O4/TiO2 heterojunctions are engineered for high‐throughput laser desorption/ionization mass spectrometry. The built‐in electric field drives efficient charge separation and photothermal conversion, while the hierarchical mesoporous network enables robust salt and protein tolerance.
Junyu Chen, Chaoqi Wang, Xi Yu, Yuming Jiang, Yijiao Qu, Huihui Fu, Yuyin Bu, Xiaoyong Zhang, Zongxiu Nie   +8 more
wiley   +1 more source

Hexahydrocannabinol-induced rhabdomyolysis and acute kidney injury: a case report combining comprehensive toxicokinetic and metabolomic investigations. [PDF]

J Cannabis Res
Thiebot P, Magny R, Willeman T, Boudin C, Brégère M, Eysseric H, Mégarbane B, Auzeil N, Labat L.   +8 more
europepmc   +1 more source

Mapping opioid exposure through prescription data and postmortem analysis of opioid drugs in multiple tissues

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2624-2635, August 2026.
Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins, Alan Wells, Nimish Patel, Nicole Muttera, Mattia Trunfio, Alessandra Manca, Amedeo De Nicolò, Micol Ferrara, Stefano Bonora, Jessica Cusato, Alice Palermiti, Antonio D'Avolio, Marissa Borochoff, Patricia K. Riggs, Elizabeth Hastie, Rabia S. Atayee, Stephanie Solso, Cheryl Dullano, Vanessa Gomez‐Moreno, Tara Tenenbaum, Robert Deiss, Davey M. Smith, Antoine Chaillon, Sara Gianella   +23 more
wiley   +1 more source

Phytochemicals From Herbs and Spices: Their Absorption, Metabolism, and Relationship to Clinical Outcomes. [PDF]

Nutr Rev
Huang Y, Petersen KS, Kris-Etherton PM, Edirisinghe I, Sandhu AK, Burton-Freeman BM.   +5 more
europepmc   +1 more source

Endogenous melatonin partial metabolic clearance as a potential endogenous marker of CYP1A2 activity

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2899-2908, August 2026.
Aims Cytochrome P450 1A2 (CYP1A2) exhibits substantial interindividual variability, necessitating appropriate phenotyping strategies for personalized pharmacotherapy. This study evaluated endogenous melatonin partial metabolic clearance (CLm(MEL)), calculated from urinary 6‐hydroxymelatonin (6‐O‐MEL) excretion and plasma melatonin (MEL) exposure, as a ...
Akitomo Yokokawa, Hayato Shimazaki, Shunji Igarashi, Yoshiki Tagawa, Naoki Hisada, Hiromi Shibasaki   +5 more
wiley   +1 more source

Synthetic cannabinoids in human post-mortem samples - ADB-BUTINACA and metabolites in three fatalities. [PDF]

Front Toxicol
Zschiesche A, Köpfler S, Wunder C, Keiler AM, Görg J, Walz CP, Fliss B, Germerott T, Auwärter V, Huppertz LM.   +9 more
europepmc   +1 more source

Targeted delivery of vitamin D to the colon using β-glucuronides of vitamin D: therapeutic effects in a murine model of inflammatory bowel disease.

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2012
J. Goff, N. Koszewski, J. Haynes, R. Horst   +3 more
semanticscholar   +1 more source