Results 121 to 130 of about 33,429 (298)
Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 614-638, September 2026.Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu +6 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 795-805, September 2026.Acetaminophen overdose can cause liver injury. Hepatotoxicity results from N‐acetyl‐p‐benzoquinone imine (NAPQI), generated via cytochrome P450‐2E1 (CYP2E1). Acetylcysteine is the mainstay of treatment, but efficacy may be reduced with delayed administration or large ingestions.
Sidharth Anand +6 more
wiley +1 more source
A New Rapid In Vitro Assay for Assessing Reactivity of Acyl Glucuronides
Drug Metabolism And Disposition, 2015 Sheng Zhong +4 more
semanticscholar +1 more source
Codeine and Metabolite Concentrations in the Breastfed Neonate
Pediatric Anesthesia, Volume 36, Issue 9, Page 1016-1022, September 2026.ABSTRACT Analgesic effect from codeine is from its metabolite, morphine. Morphine is formed by the O‐demethylation of codeine and that enzyme is controlled by the cytochrome P450 2D6. More than 60 alleles in the CYP2D6 gene have been identified. This spectrum of polymorphism can be categorized into four groups: poor (PM), intermediate (IM), normal (NM),
Brian J. Anderson, Jacqueline A. Hannam
wiley +1 more source
Resveratrol: Advance on the Most Recent Research From 2021 to 2025
Phytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.This review summarizes recent progress in resveratrol research (2021–2025), highlighting its natural sources, bioactivities, clinical evidence, and safety profiles. Resveratrol exerts multi‐target effects through the regulation of oxidative stress, inflammation, mitochondrial function, and gut microbiota.
Quanyong Wu +4 more
wiley +1 more source
Sustainable Food Proteins, Volume 4, Issue 3, September 2026.Yarrow phenolics modulate the interfacial and thermal behavior of lupin protein‐stabilized nanoemulsions through noncovalent interactions, altering droplet size, viscoelastic properties, and protein structure. ABSTRACT The effect of phenolic compounds extracted from yarrow (Achillea millefolium L.) in the interfacial stabilization of oil–water ...
María de las Nieves Siles‐Sánchez +3 more
wiley +1 more source
Structure Elucidation and Initial Characterization of a N-glucuronide Metabolite (M1) of Tuvusertib. [PDF]
Eur J Drug Metab PharmacokinetLang B +6 more
europepmc +1 more source
Identification of Potential Vaccine Strains of Escherichia coli Isolates From Diarrhoeic Calves
Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.This study aimed to identify vaccine candidate Escherichia coli strains isolated from diarrheic calves. Faecal samples collected from 500 calves were analysed, and E. coli strains were isolated and characterized phenotypically and genotypically. Antibiotic resistance profiles, virulence‐associated genes and MLVA genotyping were used to select 20 ...
Yasemin Erdoğan +16 more
wiley +1 more source
The American Journal on Addictions, Volume 35, Issue 5, Page 638-642, September 2026.Abstract Background and Objectives Poppy seed tea (PST) contains unpredictable opioid concentrations, destabilising tolerance and increasing overdose risk. Extended‐release buprenorphine (BUP‐XR) provides sustained coverage without daily dosing. Methods Eighteen‐month follow‐up of adults (N = 3) with opioid use disorder (OUD) involving PST in Australia.
John McMaster +4 more
wiley +1 more source