Results 111 to 120 of about 41,898 (332)

Synthesis, Molecular Docking and Biological Evaluation of Glycyrrhizin Analogs as Anticancer Agents Targeting EGFR

Molecules, 2014
Glycyrrhizin (GA) analogs in the form of 3-glucuronides and 18-epimers were synthesized and their anticancer activities were evaluated. Alkaline isomerization of monoglucuronides is reported.
Yong-An Yang, Wen-Jian Tang, Xin Zhang, Ji-Wen Yuan, Xin-Hua Liu, Hai-Liang Zhu   +5 more
doaj   +1 more source

Macrophage as a Target of Quercetin Glucuronides in Human Atherosclerotic Arteries

Journal of Biological Chemistry, 2008
Epidemiological studies suggest that the consumption of flavonoid-rich diets decreases the risk of cardiovascular diseases. However, the target sites of flavonoids underlying the protective mechanism in vivo are not known.
Y. Kawai, T. Nishikawa, Y. Shiba, Satomi Saito, K. Murota, N. Shibata, Makio Kobayashi, Masaya Kanayama, K. Uchida, J. Terao   +9 more
semanticscholar   +1 more source

Non-targeted metabolite profiling highlights the potential of strawberry leaves as a resource for specific bioactive compounds [PDF]

, 2017
Background: The non-edible parts of horticultural crops, such as leaves, contain substantial amounts of valuable bioactive compounds which are currently only little exploited.
Aaby, Alvarez-Suarez, Barve, Bialasiewicz, Buendía, Calderón-Montaño, Concerning the Registration, Evaluation, Day, DuPont, Espín, Everette, Fait, Farag, Giampieri, Gigot, Gulen, Hanhineva, Hanhineva, Hokkanen, Hukkanen, Ibrahim, Karaçelik, Keutgen, Kuczkowia, Kårlund, Kårlund, Lavola, Liberal, Lou, Mahesh, Monagas, Mudnic, Nakamura, Oszmiański, Peschel, Soukas, Stewart, Teleszko, Terao, Tulipani, Vagiri, Wang, Yang   +42 more
core   +2 more sources

A Comprehensive Review on Nutrition, Phytochemistry, Pharmacology and Food Application Perspectives of Bioactive Rich Superfruits

Future Postharvest and Food, EarlyView.
The review critically evaluated and compared the selected superfruit phytochemistry, their bioactive composition and the key health benefits majorly emphasizing the antioxidant potential. It has highlighted the translational challenges in formulating functional foods by addressing the issues related to delivery system, bioavailability mechanism and the
Sharath Kumar Nagaraja, Javid Iqbal Mir, Mahendra Kumar Verma, Aamir Hussain Dar   +3 more
wiley   +1 more source

Increased plasma bile alcohol glucuronides in patients with cerebrotendinous xanthomatosis: effect of chenodeoxycholic acid

Journal of Lipid Research, 1987
Large quantities of C27 bile alcohols hydroxylated at C-25 are excreted in the bile and urine of patients with cerebrotendinous xanthomatosis, a lipid storage disease that results from defective bile acid synthesis.
A K Batta, G Salen, S Shefer, G S Tint, M Batta   +4 more
doaj   +1 more source

Urolithin A, a Diet‐Derived Gut Microbial Metabolite Against Pulmonary Hypertension Identified via Molecular Docking, Molecular Dynamics and Surface Plasmon Resonance

Food Safety and Health, EarlyView.
Urolithin A, a gut microbial metabolite, binds TNF to suppress proliferation, inflammation, and oxidative stress, offering a promising microbe‐derived therapeutic avenue for pulmonary hypertension. ABSTRACT Pulmonary hypertension (PH) is a complex and multifactorial disease that poses a significant clinical challenge.
Yujie Qu, Yinghua Huo, Yichen Wang, Yao Mu, Xue Yu, Leiyu Tian, Jian Guo, Xuezhi Yang, Yucai Chen   +8 more
wiley   +1 more source

Causal Interplay Between Inflammatory Cytokines and Lipid Metabolites in Serous Ovarian Carcinoma: Insights From a Genetic Association Study

Journal of Clinical Laboratory Analysis, EarlyView.
This study utilizes a two‐sample Mendelian randomization framework to establish a causal link between circulating inflammatory proteins, blood metabolites, and the risk of serous ovarian carcinoma. Our findings identify Interleukin‐8 as a significant risk factor and demonstrate that 1‐Palmitoyl‐GPG (16:0) acts as a metabolic mediator within this ...
Chong‐ze Yang, Lan‐hui Qin, Cheng‐can Huang, Xiao‐li Huang, Ying‐xia Yang, Wei Lan, Miao Fan   +6 more
wiley   +1 more source

Glucuronide metabolism in plants. 3. Triterpene glucuronides [PDF]

Biochemical Journal, 1956
C A, MARSH, G A, LEVVY
openaire   +2 more sources

Echinacea sanguinea and Echinacea pallida Extracts Stimulate Glucuronidation and Basolateral Transfer of Bauer Alkamides 8 and 10 and Ketone 24 and Inhibit P-glycoprotein Transporter in Caco-2 Cells [PDF]

, 2013
The use of Echinacea as a medicinal herb is prominent in the United States, and many studies have assessed the effectiveness of Echinacea as an immunomodulator.
Hauck, Catharine, Hendrich, Suzanne, Hendrich, Suzanne, McCoy, Joe-Ann, Murphy, Patricia, Qiang, Zhiyi, Reddy, Manju, Reddy, Manju, Widrlechner, Mark, Widrlechner, Mark   +9 more
core   +3 more sources

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source