Results 151 to 160 of about 41,898 (332)

Unveiling Hepatic Protein Alterations in Neonatal and Infant Biliary Atresia

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1584-1596, June 2026.
Pediatric populations differ from adults in drug elimination capacity. While current scaling methods account for enzyme and transporter maturation, they overlook comorbidities, such as biliary atresia (BA), a liver disease appearing within the first 2–8 weeks of life that can progress to cirrhosis.
Zubida M. Al‐Majdoub, Martyn Howard, Brahim Achour, Jill Barber, Naved Alizai, Amin Rostami‐Hodjegan   +5 more
wiley   +1 more source

Gestational Polyphenol Levels and Risk of Atopic and Respiratory Outcomes in Early‐Life: Insights From the LiNA Study

Allergy, EarlyView.
Sergio Gómez‐Olarte, Carolin Huber, Stefan Röder, Ulrich Sack, Michael Borte, Martin Krauss, Werner Brack, Ana C. Zenclussen, Gunda Herberth   +8 more
wiley   +1 more source

CHD4 Orchestrates Chromatin Remodeling to Activate the c‐Myc Signaling Pathway in Cancer Pathogenesis

MedComm – Oncology, Volume 5, Issue 2, June 2026.
CHD4 plays an essential role as an epigenetic regulator in the pathogenesis of multiple myeloma. The chromatin remodeling protein initially resolves G‐quadruplex (G4) secondary structures within the c‐Myc promoter region, thereby enhancing chromatin accessibility and promoting transcriptional activation.
Pinggang Ding, Yuhao Cao, Zihao Liu, Jingru Xie, Lingling Liu, Shanliang Sun, Xichao Yu, Zhendong Deng, Zhimin Fan, Ye Yang, Chunyan Gu   +10 more
wiley   +1 more source

Glucuronide [PDF]

, 2020
openaire   +1 more source

Decline of phosphatidylethanol (B‐PEth) during abstinence in patients with alcohol use disorder undergoing withdrawal treatment, and the correlation of B‐PEth with self‐reported alcohol intake

Addiction, Volume 121, Issue 6, Page 1474-1482, June 2026.
Abstract Background and aim Accurately estimating alcohol consumption is crucial for clinical decision‐making and monitoring treatment outcomes. Phosphatidylethanol in blood (B‐PEth), a direct alcohol biomarker, is currently the most reliable indicator of alcohol intake, with a detection window of several weeks; however, the factors influencing the ...
Andrea de Bejczy, Lisa Walther, Cecilia Nilsson‐Wallmark, Barbro Askerup, Anders Isaksson   +4 more
wiley   +1 more source

Ecopipam, a Dopamine D1 Receptor Antagonist: Pharmacokinetics, Mass Balance, and Metabolism in Healthy Volunteers

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Ecopipam is a dopamine‐1 (D1) receptor antagonist in development for Tourette syndrome. In vitro data showed that ecopipam is metabolized to ecopipam glucuronide through uridine diphosphate‐glucuronosyltransferase 1A9 and to EBS‐101‐40853 (previously called N‐desmethylecopipam or SCH 40853) through cytochrome P450 3A4.
Virginia D. Schmith, Stephen English, Angela Dymond, Catherine Holdsworth, Ruth Stow, Emma Holbrook, Joy Schleyer, Stephen P. Wanaski   +7 more
wiley   +1 more source

Vaginal Microbiota and Ovarian Cancer: A New Frontier in Immunomodulation and Diagnosis

Immunology, Volume 178, Issue 2, Page 209-217, June 2026.
Microbial imbalance, dysbiosis, plays a role in ovarian carcinogenesis by interacting with the immune system and altering inflammatory pathways, notably Th17 pathways. In contrast, eubiosis, characterised by Lactobacillus dominance, protects against infections and maintains hormone metabolism.
Wafa Babay, Mariem Garci, Ahmed Baligh Laaribi, Nabil Mathlouthi, Imene Ouzari   +4 more
wiley   +1 more source

Characterization of the Formation of the Acyl Glucuronide Metabolite of 7-Carboxy-Cannabidiol in Human Liver, Kidney, and Intestinal Microsomes and <i>in Vivo</i> in Mice. [PDF]

ACS Med Chem Lett
Simon KT, Hailemariam SE, Friedman E, Wen YW, Freaney M, Barker-Haliski M, Isoherranen N.   +6 more
europepmc   +1 more source

Degradation kinetics of azirdinyl quinoid antitumour agents [PDF]

, 1985
Beijen, J.H., Driebergen, R.J., Hodes, T.J.M., Holthuis, J.J.M., Reinhoudt, D.N., Underberg, W.J.M.   +5 more
core   +2 more sources

Phenol Neurolysis in Pain and Palliative Medicine

Pain Practice, Volume 26, Issue 5, June 2026.
ABSTRACT Background Pain is a common symptom in palliative care and affects patients' quality of life considerably. Standard analgesics are sometimes insufficient and are associated with substantial side effects. Neurolysis, the targeted destruction of nerves using thermal or chemical agents, offers an additional option for managing localized pain in ...
Jeroen H. A. Creemers, Rachel J. H. Smits, Alopi M. Patel, Robert T. M. van Dongen, Cornelis K. Kramers, Jacqueline M. Bos, Selina E. I. van der Wal   +6 more
wiley   +1 more source