Results 81 to 90 of about 12,956 (251)
Molecules, 2014 Glycyrrhizin (GA) analogs in the form of 3-glucuronides and 18-epimers were synthesized and their anticancer activities were evaluated. Alkaline isomerization of monoglucuronides is reported.
Yong-An Yang +5 more
doaj +1 more source
Addiction, EarlyView.Abstract Background and Aims Psychedelic drugs may help treat alcohol use disorder (AUD). This study evaluated BPL‐003, a novel intranasal powder formulation of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) benzoate salt, in people with moderate–severe AUD enrolled in a standard of care, 10‐week programme of relapse‐prevention oriented Cognitive ...
John Marsden +10 more
wiley +1 more source
Journal of Lipid Research, 1987 Large quantities of C27 bile alcohols hydroxylated at C-25 are excreted in the bile and urine of patients with cerebrotendinous xanthomatosis, a lipid storage disease that results from defective bile acid synthesis.
A K Batta +4 more
doaj +1 more source
Synthesis of cortol 3-glucuronides and cortolone 3-glucuronides.
Chemical and Pharmaceutical Bulletin, 1984 The synthesis of the 3-glucuronides of 20α-cortolone and their 20β-epimers is described. The cortol 20, 21-diacetates (3, 10) and cortolone 20, 21-diacetates (6, 12) were the key intermediates. Sodium borohydride reduction of the carbonyl group at C-20 in 21-acetoxy-3α, 11β, 17α-trihydroxy-5β-pregnan-20-one 3-tert-butyldimethylsilyl ether (1) or its 11-
H, Hosoda, H, Yokohama, T, Nambara
openaire +3 more sources
Development and validation of a method for the simultaneous analysis of fatty acid ethyl esters, ethyl sulfate and ethyl glucuronide in neonatal meconium: application in two cases of alcohol consumption during pregnancy [PDF]
, 2021 Mateusz Kacper Woźniak +7 more
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Addiction, EarlyView.Abstract Background and aim Accurately estimating alcohol consumption is crucial for clinical decision‐making and monitoring treatment outcomes. Phosphatidylethanol in blood (B‐PEth), a direct alcohol biomarker, is currently the most reliable indicator of alcohol intake, with a detection window of several weeks; however, the factors influencing the ...
Andrea de Bejczy +4 more
wiley +1 more source
Rapid Methods To Enumerate Escherichia coli in Foods Using 4-Methylumbelliferyl-ß-D-Glucuronide [PDF]
, 2001 Diane F Ekholm, Irvin N. Hirshfield
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Addiction, EarlyView.Abstract Background and aims Mandated reduction of the nicotine content of cigarettes to reduce addictiveness to minimal levels has the potential to substantially reduce combusted cigarette use and promote public health. This paper examined the hypothesis that when people who smoke cigarettes are switched to very low nicotine content (VLNC) cigarettes ...
Neal L. Benowitz +8 more
wiley +1 more source
Rapid HPLC-Electrospray Tandem Mass Spectrometric Assay for Urinary Testosterone and Dihydrotestosterone Glucuronides from Patients with Benign Prostate Hyperplasia [PDF]
, 2003 Man Ho Choi +2 more
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British Journal of Pharmacology, EarlyView.Background The activity of CYP2C9, an important drug metabolism enzyme, is subject to the impact of genetic polymorphism. The single nucleotide polymorphism *3 is significantly associated with the increased exposure of CYP2C9 substrates. In addition, metabolic enzyme inhibitors such as fluconazole may also increase the drug exposure of CYP2C9 ...
Shen Cheng +5 more
wiley +1 more source