Results 1 to 10 of about 25,858 (256)

Apalutamide treatment and refractory hypothyroidism: effects of apalutamide on levothyroxine metabolism [PDF]

European Thyroid Journal
Apalutamide, a selective androgen receptor antagonist, is a new treatment for prostate cancer. Among the side effects observed during apalutamide treatment, an increased risk of hypothyroidism has been reported, particularly in patients previously ...
Florie Quattrochi, Solange Grunenwald, Philippe Caron   +2 more
doaj   +2 more sources

Biosynthesis of hydroxyl-linked glucuronides of short-chain bile acids by rat liver 3-hydroxysteroid UDP-glucuronosyltransferase.

Journal of Lipid Research, 1988
Microsomal preparations from livers of Sprague-Dawley rats catalyze the glucuronidation of 3 alpha-hydroxy-5 beta-H (3 alpha, 5 beta) short-chain bile acids (C20-C23), predominantly at the hydroxyl group, while the glucuronidation of 3 beta, 5 beta short-
A Radominska, M D Green, P Zimniak, R Lester, T R Tephly   +4 more
doaj   +2 more sources

UDP-Glucuronosyltransferase 2B15 [PDF]

, 2020
National Cancer Institute
openalex   +2 more sources

Economic evaluations of pharmacogenetic and pharmacogenomic screening tests : a systematic review : second update of the literature [PDF]

, 2016
Objective : Due to extended application of pharmacogenetic and pharmacogenomic screening (PGx) tests it is important to assess whether they provide good value for money. This review provides an update of the literature. Methods : A literature search was
Annemans, Lieven, Berm, Elizabeth JJ, Boersma, Cornelis, de Looff, Margot, Postma, Maarten J, van Boven, Job FM, Vegter, Stefan, Wilffert, Bob   +7 more
core   +19 more sources

Liver Transplantation in a Patient with Crigler-Najjar Syndrome Type 1: A Case Report of Two Cases

Archives of Anesthesia and Critical Care, 2023
Crigler Najjar syndrome(CNS); is a disease in which the diphosphate glucuronosyltransferase (bilirubin-UGT) enzyme function, which plays a role in the glucuronidation of bilirubin, is deficient as a result of mutation in the uridine 5'-diphosphate ...
Ahmed Uslu, Nedim Çekmen, Zeynep Ersoy, Adnan Torgay   +3 more
doaj   +1 more source

Gene excavation and expression analysis of CYP and UGT related to the post modifying stage of gypenoside biosynthesis in Gynostemma pentaphyllum (Thunb.) Makino by comprehensive analysis of RNA and proteome sequencing

PLoS ONE, 2021
Previous studies have revealed that gypenosides produced from Gynostemma pentaphyllum (Thunb.) Makino are mainly dammarane-type triterpenoid saponins with diverse structures and important biological activities, but the mechanism of diversity for ...
Yangmei Zhang, Qicong Chen, Yuanheng Huang, Ruiqiang Zhao, Jian Sun, Xidong Yuan, Huiming Xu, Huiyu Liu, Yaosheng Wu   +8 more
doaj   +2 more sources

Pharmacokinetics and Pharmacogenetics of Dabigatran

Рациональная фармакотерапия в кардиологии, 2021
Dabigatran etexilate is a prodrug of dabigatran, a oral direct inhibitor of thrombin. Pharmacokinetics of dabigatran etexilate doesn’t have the disadvantages of vitamin K antagonists.
A. V. Savinova, V. S. Dobrodeeva, M. M. Petrova, R. F. Nasyrova, N. A. Shnayder   +4 more
doaj   +1 more source

Inherited Unconjugated Hyperbilirubinemias and Radical Cancer surgery: Perioperative Concerns for Bilateral Modified Radical Mastectomy

Archives of Anesthesia and Critical Care, 2022
Inherited defects of Uridine 5'-diphospho-glucuronosyltransferase (UDPGT) can cause congenital unconjugated hyperbilirubinemia. The perioperative anesthetic management of such patients poses several challenges.
Amit Kumar, Uma Hariharan, Vijay K Nagpal, Devang Bharti   +3 more
doaj   +1 more source

Quantitative analysis of the UDP‐glucuronosyltransferase transcriptome in human tissues

Pharmacology Research & Perspectives, 2023
UDP‐glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that play important roles in the detoxification of endogenous and exogenous substrates.
Lucas Zhou, Abelardo D. Montalvo, Joseph M. Collins, Danxin Wang   +3 more
doaj   +1 more source

Population genetic research of the mutation in ugt1a1 gene associated with reduced activity of liver UDP-glucuronosyltransferase A1

Фундаментальная и клиническая медицина, 2020
Aim. To explore allele and genotype frequencies of the rs8175347 polymorphism within the UGT1A1 gene in Kemerovo Region. Materials and Methods. The study sample included 64 male and 68 female inhabitants of the Kemerovo Region.
A. N. Volkov
doaj   +1 more source