Results 1 to 10 of about 30,656 (311)

Pharmacogenomics of human UDP-glucuronosyltransferase enzymes [PDF]

The Pharmacogenomics Journal, 2003
UDP-glucuronosyltransferase (UGT) enzymes comprise a superfamily of key proteins that catalyze the glucuronidation reaction on a wide range of structurally diverse endogenous and exogenous chemicals. Glucuronidation is one of the major phase II drug-metabolizing reactions that contributes to drug biotransformation.
Chantal Guillemette
semanticscholar   +5 more sources

Arabidopsis thalianaglucuronosyltransferase in family GT14 [PDF]

Plant Signaling & Behavior, 2014
Arabinogalactan proteins are abundant cell-surface proteoglycans in plants and are involved in many cellular processes including somatic embryogenesis, cell-cell interactions, and cell elongation. We reported a glucuronosyltransferase encoded by Arabidopsis AtGlcAT14A, which catalyzes an addition of glucuronic acid residues to β-1,3- and β-1,6-linked ...
Dilokpimol, Adiphol, Geshi, Naomi
openaire   +6 more sources

Age-dependent Hepatic UDP-glucuronosyltransferase Gene Expression and Activity in Children

Frontiers in Pharmacology, 2016
UDP-glucuronosyltransferases (UGTs) are important phase II drug metabolism enzymes. The aim of this study was to explore the relationship between age and changes in mRNA expression and activity of major human hepatic UGTs, as well as to understand the ...
Elizabeth Neumann, Huma Mehboob, Huma Mehboob, Jacqueline Ramírez, Snezana Mirkov, Min Zhang, Wanqing Liu   +6 more
doaj   +2 more sources

Comparative transcriptomics reveals different profiles between diflubenzuron-resistant and -susceptible phenotypes of the mosquito Culex pipiens. [PDF]

Pest Manag Sci
Comparative gene expression analysis between susceptible and diflubenzuron‐resistant individuals of the mosquito Culex pipiens revealed transcriptional changes of multiple genes associated with insecticide detoxification and cuticle synthesis. Abstract Background Chitin‐synthesis inhibitors (CSIs) represent a major tool in vector control. The intensive
Valentina M, Franco L, Tiziana C, Valentina L, Sandra U, Romeo B, John V, Daniele P.   +7 more
europepmc   +2 more sources

Transcriptomic Association Analysis of the Metabolic Mechanism of Sulfamethoxazole in Channel Catfish (Ictalurus punctatus) [PDF]

Animals
Sulfamethoxazole is a widely used antimicrobial drug used to treat bacterial diseases in aquaculture. To understand the gene expression in channel catfish liver after treatment with sulfamethoxazole, in this study, the treatment group received ...
Xiangxuan Du, Ruyu Sun, Lei Zhang, Yongtao Liu, Xiaohui Ai   +4 more
doaj   +2 more sources

The Survival and Physiological Response of Calliptamus abbreviatus Ikonn (Orthoptera: Acrididae) to Flavonoids Rutin and Quercetin [PDF]

Insects
Insect-resistant substances from plants are important natural resources that human beings can potentially develop and use to control pests. In this study, we explored the adverse effects of rutin and quercetin on grasshopper (Calliptamus abbreviatus), as
Xunbing Huang, Li Zheng, Yueyue Wang
doaj   +2 more sources

Gene excavation and expression analysis of CYP and UGT related to the post modifying stage of gypenoside biosynthesis in Gynostemma pentaphyllum (Thunb.) Makino by comprehensive analysis of RNA and proteome sequencing.

PLoS ONE, 2021
Previous studies have revealed that gypenosides produced from Gynostemma pentaphyllum (Thunb.) Makino are mainly dammarane-type triterpenoid saponins with diverse structures and important biological activities, but the mechanism of diversity for ...
Yangmei Zhang, Qicong Chen, Yuanheng Huang, Ruiqiang Zhao, Jian Sun, Xidong Yuan, Huiming Xu, Huiyu Liu, Yaosheng Wu   +8 more
doaj   +2 more sources

Inhibition of UDP-Glucuronosyltransferase Enzymes by Major Cannabinoids and Their Metabolites

Drug Metabolism And Disposition, 2021
The UDP-glucuronosyltransferase (UGT) family of enzymes play a central role in the metabolism and detoxification of a wide range of endogenous and exogenous compounds.
Shamema Nasrin, C. Watson, Keti Bardhi, Gabriela Fort, Gang Chen, P. Lazarus   +5 more
semanticscholar   +1 more source

The Functionality of UDP-Glucuronosyltransferase Genetic Variants and their Association with Drug Responses and Human Diseases

Journal of Personalized Medicine, 2021
UDP-glucuronosyltransferases (UGTs) are phase II drug-metabolizing enzymes that metabolize endogenous fatty acids such as arachidonic acid metabolites, as well as many prescription drugs, such as opioids, antiepileptics, and antiviral drugs.
Y. Jarrar, Su-Jun Lee
semanticscholar   +1 more source

Liver Transplantation in a Patient with Crigler-Najjar Syndrome Type 1: A Case Report of Two Cases

Archives of Anesthesia and Critical Care, 2023
Crigler Najjar syndrome(CNS); is a disease in which the diphosphate glucuronosyltransferase (bilirubin-UGT) enzyme function, which plays a role in the glucuronidation of bilirubin, is deficient as a result of mutation in the uridine 5'-diphosphate ...
Ahmed Uslu, Nedim Çekmen, Zeynep Ersoy, Adnan Torgay   +3 more
doaj   +1 more source