Results 1 to 10 of about 24,843 (280)

A mutation which disrupts the hydrophobic core of the signal peptide of bilirubin UDP-glucuronosyltransferase, an endoplasmic reticulum membrane protein, causes Crigler-Najjar type II [PDF]

, 1996
Crigler-Najjar (CN) disease is caused by a deficiency of the hepatic enzyme, bilirubin UDP-glucuronosyltransferase (B-UGT). We have found two CN type II patients, who were homozygous for a leucine to arginine transition at position 15 of B-UGT1.
Andersson, Arnold, Bosma, Bosma, Burchell, Chomczynski, Deng, Ito, Jansen, Karaplis, Mackenzie, Mackenzie, Ouzzine, Owens, Peters, Racchi, Rapoport, Ritter, Seppen, Sinaasappel, von Heijne, Zimmermann   +21 more
core   +3 more sources

Pharmacogenomics of human UDP-glucuronosyltransferase enzymes [PDF]

The Pharmacogenomics Journal, 2003
UDP-glucuronosyltransferase (UGT) enzymes comprise a superfamily of key proteins that catalyze the glucuronidation reaction on a wide range of structurally diverse endogenous and exogenous chemicals. Glucuronidation is one of the major phase II drug-metabolizing reactions that contributes to drug biotransformation.
Chantal Guillemette
openaire   +4 more sources

Gene excavation and expression analysis of CYP and UGT related to the post modifying stage of gypenoside biosynthesis in Gynostemma pentaphyllum (Thunb.) Makino by comprehensive analysis of RNA and proteome sequencing.

PLoS ONE, 2021
Previous studies have revealed that gypenosides produced from Gynostemma pentaphyllum (Thunb.) Makino are mainly dammarane-type triterpenoid saponins with diverse structures and important biological activities, but the mechanism of diversity for ...
Yangmei Zhang, Qicong Chen, Yuanheng Huang, Ruiqiang Zhao, Jian Sun, Xidong Yuan, Huiming Xu, Huiyu Liu, Yaosheng Wu   +8 more
doaj   +2 more sources

Liver Transplantation in a Patient with Crigler-Najjar Syndrome Type 1: A Case Report of Two Cases

Archives of Anesthesia and Critical Care, 2023
Crigler Najjar syndrome(CNS); is a disease in which the diphosphate glucuronosyltransferase (bilirubin-UGT) enzyme function, which plays a role in the glucuronidation of bilirubin, is deficient as a result of mutation in the uridine 5'-diphosphate ...
Ahmed Uslu, Nedim Çekmen, Zeynep Ersoy, Adnan Torgay   +3 more
doaj   +1 more source

Pharmacokinetics and Pharmacogenetics of Dabigatran

Рациональная фармакотерапия в кардиологии, 2021
Dabigatran etexilate is a prodrug of dabigatran, a oral direct inhibitor of thrombin. Pharmacokinetics of dabigatran etexilate doesn’t have the disadvantages of vitamin K antagonists.
A. V. Savinova, V. S. Dobrodeeva, M. M. Petrova, R. F. Nasyrova, N. A. Shnayder   +4 more
doaj   +1 more source

Common genetic variation in cellular transport genes and epithelial ovarian cancer (EOC) risk [PDF]

, 2015
Background Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and ...
Agnieszka Dansonka-Mieszkowska, Aleksandra Gentry-Maharaj, Alexander Hein, Alice S Whittemore, Alice W Lee, Allan Jensen, Alvaro N A Monteiro, Andreas du Bois, Andrew Berchuck, Angela Brooks-Wilson, Anja Rudolph, Ann Y Chen, Anna H Wu, Anna Jakubowska, Anne M van Altena, AOCS management group, Argyrios Ziogas, Arif B Ekici, Arto Leminen, Barry Rosen, Beata Spiewankiewicz, Beth Y Karlan, Boon Kiong Lim, Brooke L Fridley, Bu-Tian Ji, Camilla Krakstad, Catherine M Phelan, Celeste L Pearce, Cezary Cybulski, Christine S Walsh, Clareann H Bunker, Claus K Hogdall, Daniel W Cramer, Diana M Eccles, Diether Lambrechts, Dong Liang, Douglas A Levine, Douglas F Easton, Ed Dicks, Edwin S Iversen, Elisa V Bandera, Elizabeth M Poole, Ellen L Goode, Ernest K Amankwah, Estrid Hogdall, Eva Schernhammer, Evelyn Despierre, Fiona Bruinsma, Florian Heitz, Francesmary Modugno, Ganna Chornokur, Georgia Chenevix-Trench, Graham G Giles, Hanis N Hasmad, Hannah Yang, Harvey A Risch, Heather S L Jim, Helga B Salvesen, Heli Nevanlinna, Hoda Anton-Culver, Honglin Song, Hui-Yi Lin, Iain McNeish, Ian G Campbell, Ignace Vergote, Ingo B Runnebaum, Ingvild L Tangen, Ira Schwaab, Irene Orlow, Iwona K Rzepecka, Jacek Gronwald, James Paul, Jan Lubinski, Jennifer A Doherty, Jennifer Permuth-Wey, Jenny Chang-Claude, Jenny Lester, Joe Dennis, Joellen M Schildkraut, John R McLaughlin, Jolanta Kupryjanczyk, Jolanta Lissowska, Jonathan P Tyrer, Joseph H Rothstein, Julie M Cunningham, Karen Carty, Karen Lu, Kate Lawrenson, Kathryn L Terry, Katja K H Aben, Keitaro Matsuo, Kirsten B Moysich, Kristine G Wicklund, Kunle Odunsi, Lambertus A Kiemeney, Lara Sucheston, Lene Lundvall, Leon F A G Massuger, Liisa M Pelttari, Linda E Kelemen, Linda S Cook, Line Bjorge, Lotte Thomsen, Louise A Brinton, Lynne R Wilkens, Malcolm C Pike, Marc T Goodman, Maria Bisogna, Mary Anne Rossing, Matthias Dürst, Matthias W Beckmann, Melissa C Southey, Mellissa Kellar, Michelle A T Hildebrandt, Nadeem Siddiqui, Natalia Antonenkova, Natalia Bogdanova, Nhu D Le, Nicolas Wentzensen, Pamela J Thompson, Patricia Harrington, Paul D P Pharoah, Peter A Fasching, Peter Hillemanns, Philipp Harter, Rachel Palmieri Weber, Ralf Butzow, Robert A Vierkant, Robert P Edwards, Roberta B Ness, Roger L Milne, Rosalind Glasspool, Sandra Orsulic, Sandrina Lambrechts, Sara H Olson, Satoyo Hosono, Shan Wang-Gohrke, Shashi Lele, Shelley S Tworoger, Simon A Gayther, Soo-Hwang Teo, Steven A Narod, Susan J Ramus, Susanne K Kjaer, Tanja Pejovic, Thilo Dörk, Thomas A Sellers, Ursula Eilber, Usha Menon, Valerie McGuire, Wei Zheng, Weiva Sieh, Xiao-Ou Shu, Xiaotao Qu, Xifeng Wu, Ya-Yu Tsai, Yin-Ling Woo, Yu-Tang Gao, Yukie T Bean, Yurii B Shvetsov, Zhihua Chen   +160 more
core   +16 more sources

Inherited Unconjugated Hyperbilirubinemias and Radical Cancer surgery: Perioperative Concerns for Bilateral Modified Radical Mastectomy

Archives of Anesthesia and Critical Care, 2022
Inherited defects of Uridine 5'-diphospho-glucuronosyltransferase (UDPGT) can cause congenital unconjugated hyperbilirubinemia. The perioperative anesthetic management of such patients poses several challenges.
Amit Kumar, Uma Hariharan, Vijay K Nagpal, Devang Bharti   +3 more
doaj   +1 more source

Quantitative analysis of the UDP‐glucuronosyltransferase transcriptome in human tissues

Pharmacology Research & Perspectives, 2023
UDP‐glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that play important roles in the detoxification of endogenous and exogenous substrates.
Lucas Zhou, Abelardo D. Montalvo, Joseph M. Collins, Danxin Wang   +3 more
doaj   +1 more source

Piscine UDP-glucuronosyltransferase 1B [PDF]

Aquatic Toxicology, 2007
Glucuronidation is an important detoxification pathway for organic pollutants in fish. We report here the isolation and characterisation of UDP-glucuronosyltransferases (UGT) genes from the closely related marine flatfish, plaice (Pleuronectes platessa) and flounder (Platichthys flesus).
Leaver, Michael, Wright, Joy, Hodgson, Paul, Boukouvala, Evridiki, George, Stephen   +4 more
openaire   +3 more sources

Population genetic research of the mutation in ugt1a1 gene associated with reduced activity of liver UDP-glucuronosyltransferase A1

Фундаментальная и клиническая медицина, 2020
Aim. To explore allele and genotype frequencies of the rs8175347 polymorphism within the UGT1A1 gene in Kemerovo Region. Materials and Methods. The study sample included 64 male and 68 female inhabitants of the Kemerovo Region.
A. N. Volkov
doaj   +1 more source