AnimalsSulfamethoxazole is a widely used antimicrobial drug used to treat bacterial diseases in aquaculture. To understand the gene expression in channel catfish liver after treatment with sulfamethoxazole, in this study, the treatment group received ...
Xiangxuan Du +4 more
doaj +1 more source
Journal of Lipid Research, 2013 Increased levels of bile acids (BAs) due to the various hepatic diseases could interfere with the metabolism of xenobiotics, such as drugs, and endobiotics including steroid hormones.
Zhong-Ze Fang +14 more
doaj +1 more source
Gilbert Syndrome and the Development of Antiretroviral Therapy-Associated Hyperbilirubinemia [PDF]
, 2017 BackgroundUnconjugated hyperbilirubinemia results from Gilbert syndrome and from antiretroviral therapy (ART) containing protease inhibitors. An understanding of the interaction between genetic predisposition and ART may help to identify individuals at ...
Bernasconi, Enos +9 more
core
The clinical application of
Human Genomics, 2010 Over the past decade, the number of pharmacogenetic tests has increased considerably, allowing for the development of our knowledge of their clinical application.
Marques Sara, Ikediobi Ogechi N
doaj +1 more source
A mutation which disrupts the hydrophobic core of the signal peptide of bilirubin UDP‐glucuronosyltransferase, an endoplasmic reticulum membrane protein, causes Crigler‐Najjar type IIs [PDF]
, 1996 Jurgen Seppen +4 more
openalex +1 more source
Pharmacogenomics of human UDP-glucuronosyltransferase enzymes [PDF]
The Pharmacogenomics Journal, 2003 UDP-glucuronosyltransferase (UGT) enzymes comprise a superfamily of key proteins that catalyze the glucuronidation reaction on a wide range of structurally diverse endogenous and exogenous chemicals. Glucuronidation is one of the major phase II drug-metabolizing reactions that contributes to drug biotransformation.
openaire +2 more sources
Oligomerization of the UDP-glucuronosyltransferase 1A Proteins [PDF]
, 2006 Theresa N. Operaña, Robert H. Tukey
openalex +1 more source
Clinical and molecular study of Egyptian pediatric patients with Crigler-Najjar syndrome
Egyptian Liver JournalBackground Crigler-Najjar syndrome (CNS) is a rare autosomal recessive inherited disorder caused by uridine diphosphate-glucuronosyltransferase (UGT) enzyme deficiency. The enzyme is encoded by the uridine diphosphate-glucuronosyltransferase 1A1 (UGT1A1)
Mohammed A. Khedr +6 more
doaj +1 more source
Inhibition of UDP‐glucuronosyltransferase activity by possible transition‐state analogues in rat‐liver microsomes [PDF]
, 1990 Daan Noort +6 more
openalex +1 more source
Irinotecan pathway genotype analysis to predict pharmacokinetics [PDF]
, 2003 PURPOSE: The purpose was to explore the relationships between irinotecan disposition and allelic variants of genes coding for adenosine triphosphate binding cassette transporters and enzymes of putative relevance for irinotecan ...
Baker, S.D. (Sharyn) +7 more
core