Results 121 to 130 of about 24,745 (276)

Drug Exposure in Chronic Kidney Disease: It Is Not Just About the Glomerular Filtration Rate

Fundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.
ABSTRACT Chronic kidney disease (CKD) affects over 10% of the world's population and is associated with high morbidity and mortality rates. The management of CKD is complex; CKD alters drug pharmacokinetics and pharmacodynamics and further complicates therapeutic strategies regimens.
Sophie Liabeuf, Jessica Berdougo‐Tritz, Lucie Augey, Aïcha Mbarek, Michel Jadoul, Gilbert Deray, Ziad A. Massy   +6 more
wiley   +1 more source

Comprehensive mRNA and microRNA analysis revealed the effect and response strategy of freshwater fish, grass carp (Ctenopharyngodon idella) under geosmin exposure

Ecotoxicology and Environmental Safety
Geosmin is an environmental pollutant that causes off-flavor in water and aquatic products. The high occurrence of geosmin contamination in aquatic systems and aquaculture raises public awareness, however, few studies have investigated the response ...
Jun-ming Zhang, Huan Han, Yi-chao Li, Bing Fu, Gen Kaneko, Kang Li, Xi-chen Jin, Shuang Ji, Er-meng Yu, Li-ping Liu   +9 more
doaj  

Engineering Gypsophila elegans hairy root cultures to produce endosomal escape‐enhancing saponins

Plant Biotechnology Journal, Volume 23, Issue 8, Page 3068-3082, August 2025.
Summary The limited cytosolic delivery of DNA and protein‐based therapeutics due to endosomal entrapment reduces drug efficacy, increasing treatment costs and possible side effects in human and veterinary medicine as a consequence of higher administered dosages.
Elia Lacchini, Tongtong Qu, Tessa Moses, Alexander N. Volkov, Alain Goossens   +4 more
wiley   +1 more source

Applied physiologically‐based pharmacokinetic modeling to assess uridine diphosphate‐glucuronosyltransferase‐mediated drug–drug interactions for Vericiguat

CPT: Pharmacometrics & Systems Pharmacology
Vericiguat (Verquvo; US: Merck, other countries: Bayer) is a novel drug for the treatment of chronic heart failure. Preclinical studies have demonstrated that the primary route of metabolism for vericiguat is glucuronidation, mainly catalyzed by uridine ...
Sebastian Frechen, Ibrahim Ince, André Dallmann, Michael Gerisch, Natalia A. Jungmann, Corina Becker, Maximilian Lobmeyer, Maria E. Trujillo, Shiyao Xu, Rolf Burghaus, Michaela Meyer   +10 more
doaj   +1 more source

The Survival and Physiological Response of Calliptamus abbreviatus Ikonn (Orthoptera: Acrididae) to Flavonoids Rutin and Quercetin

Insects
Insect-resistant substances from plants are important natural resources that human beings can potentially develop and use to control pests. In this study, we explored the adverse effects of rutin and quercetin on grasshopper (Calliptamus abbreviatus), as
Xunbing Huang, Li Zheng, Yueyue Wang
doaj   +1 more source

Expression of a high-affinity form of UDP-glucuronosyltransferase in human foetal liver cells in culture on exposure to mercuric chloride [PDF]

, 1991
Theresa May Chin Tan, Kim Ping Wong, K.H. Sit   +2 more
openalex   +1 more source

Gilbert Syndrome and the Development of Antiretroviral Therapy-Associated Hyperbilirubinemia [PDF]

, 2017
BackgroundUnconjugated hyperbilirubinemia results from Gilbert syndrome and from antiretroviral therapy (ART) containing protease inhibitors. An understanding of the interaction between genetic predisposition and ART may help to identify individuals at ...
Bernasconi, Enos, Bleiber, Gabriela, Drechsler, Henning, Furrer, Hansjakob, Günthard, Huldrych F., Rickenbach, Martin, Rotger, Margalida, Taffé, Patrick, Telenti, Amalio, Vernazza, Pietro   +9 more
core  

Functional expression of uridine diphospho glucuronosyltransferases in fission yeast [PDF]

, 2011
Uridine diphospho (UDP) glucuronosyltransferases (UGTs) catalyze the transfer of a sugar moiety from UDP-sugar to endogenous or exogenous compounds. The water solubility of these substances is increased thereby and their excretion from the human body is ...
Buchheit, Daniela
core  

La farmacogenetica dei farmaci antitumorali [PDF]

, 2014
La variabilità individuale nella risposta ai farmaci è molto importante in quanto può condizionare la riuscita di un trattamento farmacologico ed è dovuta, in gran parte, al profilo genetico.
IOFRIDA, CATERINA
core  

Changes in expressions of UDP-glucuronosyltransferases in placenta and fetal liver of rats before birth induced by maternal exposure to bisphenol A during pregnancy

环境与职业医学
BackgroundMaternal exposure to bisphenol A (BPA) during pregnancy is closely related to adverse growth and development conditions such as preterm birth and low birth weight, but the relevant mechanisms are still unclear.
Peili WANG, Jun WANG, Yichen ZHAO, Panjie WANG, Mingyue MA, Zhiwen DUAN, Xiucong PEI, Haiyang YU   +7 more
doaj   +1 more source