Results 11 to 20 of about 30,656 (311)

17β-Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α [PDF]

Acta Pharmaceutica Sinica B, 2016
UDP-glucuronosyltransferase 1A9 (UGT1A9) is a major phase II enzyme responsible for elimination of drugs and endogenous molecules. Clinical data have shown increased elimination of UGT1A9 substrates in pregnant women or oral contraceptive users, but the ...
Sung-joon Cho, Miaoran Ning, Yanyan Zhang, Leah H. Rubin, Hyunyoung Jeong   +4 more
doaj   +3 more sources

Renal drug metabolism in humans: the potential for drug–endobiotic interactions involving cytochrome P450 (CYP) and UDP‐glucuronosyltransferase (UGT) [PDF]

British Journal of Clinical Pharmacology, 2013
This item is under embargo for a period of 12 months from the date of publication, in accordance with the publisher's policy. ‘This is the peer reviewed version of the following article: Knights, K. M., Rowland, A. and Miners, J. O.
K. Knights, A. Rowland, J. Miners
semanticscholar   +3 more sources

Pharmacokinetics and Pharmacogenetics of Dabigatran

Рациональная фармакотерапия в кардиологии, 2021
Dabigatran etexilate is a prodrug of dabigatran, a oral direct inhibitor of thrombin. Pharmacokinetics of dabigatran etexilate doesn’t have the disadvantages of vitamin K antagonists.
A. V. Savinova, V. S. Dobrodeeva, M. M. Petrova, R. F. Nasyrova, N. A. Shnayder   +4 more
doaj   +1 more source

Inherited Unconjugated Hyperbilirubinemias and Radical Cancer surgery: Perioperative Concerns for Bilateral Modified Radical Mastectomy

Archives of Anesthesia and Critical Care, 2022
Inherited defects of Uridine 5'-diphospho-glucuronosyltransferase (UDPGT) can cause congenital unconjugated hyperbilirubinemia. The perioperative anesthetic management of such patients poses several challenges.
Amit Kumar, Uma Hariharan, Vijay K Nagpal, Devang Bharti   +3 more
doaj   +1 more source

Quantitative analysis of the UDP‐glucuronosyltransferase transcriptome in human tissues

Pharmacology Research & Perspectives, 2023
UDP‐glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that play important roles in the detoxification of endogenous and exogenous substrates.
Lucas Zhou, Abelardo D. Montalvo, Joseph M. Collins, Danxin Wang   +3 more
doaj   +1 more source

A mutation which disrupts the hydrophobic core of the signal peptide of bilirubin UDP‐glucuronosyltransferase, an endoplasmic reticulum membrane protein, causes Crigler‐Najjar type IIs [PDF]

, 1996
Crigler-Najjar (CN) disease is caused by a deficiency of the hepatic enzyme, bilirubin UDP-glucuronosyltransferase (B-UGT). We have found two CN type II patients, who were homozygous for a leucine to arginine transition at position 15 of B-UGT1.
Jurgen Seppen, Edmee Steenken, Dick Lindhout, Piter J. Bosma, Ronald P.J. Oude Elferink   +4 more
openalex   +4 more sources

Common genetic variation in cellular transport genes and epithelial ovarian cancer (EOC) risk [PDF]

, 2015
Background Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and ...
Agnieszka Dansonka-Mieszkowska, Aleksandra Gentry-Maharaj, Alexander Hein, Alice S Whittemore, Alice W Lee, Allan Jensen, Alvaro N A Monteiro, Andreas du Bois, Andrew Berchuck, Angela Brooks-Wilson, Anja Rudolph, Ann Y Chen, Anna H Wu, Anna Jakubowska, Anne M van Altena, AOCS management group, Argyrios Ziogas, Arif B Ekici, Arto Leminen, Barry Rosen, Beata Spiewankiewicz, Beth Y Karlan, Boon Kiong Lim, Brooke L Fridley, Bu-Tian Ji, Camilla Krakstad, Catherine M Phelan, Celeste L Pearce, Cezary Cybulski, Christine S Walsh, Clareann H Bunker, Claus K Hogdall, Daniel W Cramer, Diana M Eccles, Diether Lambrechts, Dong Liang, Douglas A Levine, Douglas F Easton, Ed Dicks, Edwin S Iversen, Elisa V Bandera, Elizabeth M Poole, Ellen L Goode, Ernest K Amankwah, Estrid Hogdall, Eva Schernhammer, Evelyn Despierre, Fiona Bruinsma, Florian Heitz, Francesmary Modugno, Ganna Chornokur, Georgia Chenevix-Trench, Graham G Giles, Hanis N Hasmad, Hannah Yang, Harvey A Risch, Heather S L Jim, Helga B Salvesen, Heli Nevanlinna, Hoda Anton-Culver, Honglin Song, Hui-Yi Lin, Iain McNeish, Ian G Campbell, Ignace Vergote, Ingo B Runnebaum, Ingvild L Tangen, Ira Schwaab, Irene Orlow, Iwona K Rzepecka, Jacek Gronwald, James Paul, Jan Lubinski, Jennifer A Doherty, Jennifer Permuth-Wey, Jenny Chang-Claude, Jenny Lester, Joe Dennis, Joellen M Schildkraut, John R McLaughlin, Jolanta Kupryjanczyk, Jolanta Lissowska, Jonathan P Tyrer, Joseph H Rothstein, Julie M Cunningham, Karen Carty, Karen Lu, Kate Lawrenson, Kathryn L Terry, Katja K H Aben, Keitaro Matsuo, Kirsten B Moysich, Kristine G Wicklund, Kunle Odunsi, Lambertus A Kiemeney, Lara Sucheston, Lene Lundvall, Leon F A G Massuger, Liisa M Pelttari, Linda E Kelemen, Linda S Cook, Line Bjorge, Lotte Thomsen, Louise A Brinton, Lynne R Wilkens, Malcolm C Pike, Marc T Goodman, Maria Bisogna, Mary Anne Rossing, Matthias Dürst, Matthias W Beckmann, Melissa C Southey, Mellissa Kellar, Michelle A T Hildebrandt, Nadeem Siddiqui, Natalia Antonenkova, Natalia Bogdanova, Nhu D Le, Nicolas Wentzensen, Pamela J Thompson, Patricia Harrington, Paul D P Pharoah, Peter A Fasching, Peter Hillemanns, Philipp Harter, Rachel Palmieri Weber, Ralf Butzow, Robert A Vierkant, Robert P Edwards, Roberta B Ness, Roger L Milne, Rosalind Glasspool, Sandra Orsulic, Sandrina Lambrechts, Sara H Olson, Satoyo Hosono, Shan Wang-Gohrke, Shashi Lele, Shelley S Tworoger, Simon A Gayther, Soo-Hwang Teo, Steven A Narod, Susan J Ramus, Susanne K Kjaer, Tanja Pejovic, Thilo Dörk, Thomas A Sellers, Ursula Eilber, Usha Menon, Valerie McGuire, Wei Zheng, Weiva Sieh, Xiao-Ou Shu, Xiaotao Qu, Xifeng Wu, Ya-Yu Tsai, Yin-Ling Woo, Yu-Tang Gao, Yukie T Bean, Yurii B Shvetsov, Zhihua Chen   +160 more
core   +16 more sources

Piscine UDP-glucuronosyltransferase 1B [PDF]

Aquatic Toxicology, 2007
Glucuronidation is an important detoxification pathway for organic pollutants in fish. We report here the isolation and characterisation of UDP-glucuronosyltransferases (UGT) genes from the closely related marine flatfish, plaice (Pleuronectes platessa) and flounder (Platichthys flesus).
Leaver, Michael, Wright, Joy, Hodgson, Paul, Boukouvala, Evridiki, George, Stephen   +4 more
openaire   +3 more sources

Population genetic research of the mutation in ugt1a1 gene associated with reduced activity of liver UDP-glucuronosyltransferase A1

Фундаментальная и клиническая медицина, 2020
Aim. To explore allele and genotype frequencies of the rs8175347 polymorphism within the UGT1A1 gene in Kemerovo Region. Materials and Methods. The study sample included 64 male and 68 female inhabitants of the Kemerovo Region.
A. N. Volkov
doaj   +1 more source

Crigler-Najjar Syndrome Type 2

Journal of the Formosan Medical Association, 2006
Crigler-Najjar syndrome is a rare disorder of bilirubin metabolism with two distinct forms: type 1 and type 2. We report three patients with Crigler-Najjar syndrome type 2 (CN-2).
Ching-Shan Huang, Nancy Tan, Sien-Sing Yang, Yung-Chan Sung, May-Jen Huang   +4 more
doaj   +1 more source