Development of a Physiologically Based Model of Bilirubin Metabolism in Health and Disease and Its Comparison With Real-World Data. [PDF]
CPT Pharmacometrics Syst PharmacolABSTRACT Bilirubin is a breakdown product of erythrocytes and plays a crucial role in elimination of heme‐containing proteins. After its synthesis in the reticuloendothelial system, unconjugated bilirubin is released into plasma and taken up into the liver.
Sayin AZ, Kuepfer L.
europepmc +2 more sources
Piscine UDP-glucuronosyltransferase 1B [PDF]
Aquatic Toxicology, 2007 Glucuronidation is an important detoxification pathway for organic pollutants in fish. We report here the isolation and characterisation of UDP-glucuronosyltransferases (UGT) genes from the closely related marine flatfish, plaice (Pleuronectes platessa) and flounder (Platichthys flesus).
Leaver, Michael +4 more
openaire +3 more sources
Crigler-Najjar Syndrome Type 2
Journal of the Formosan Medical Association, 2006 Crigler-Najjar syndrome is a rare disorder of bilirubin metabolism with two distinct forms: type 1 and type 2. We report three patients with Crigler-Najjar syndrome type 2 (CN-2).
Ching-Shan Huang +4 more
doaj +1 more source
Potentially harmful advantage to athletes: a putative connection between UGT2B17 gene deletion polymorphism and renal disorders with prolonged use of anabolic androgenic steroids [PDF]
, 2010 : BACKGROUND AND OBJECTIVE: With prolonged use of anabolic androgenic steroids (AAS), occasional incidents of renal disorders have been observed. Independently, it has also been established that there are considerable inter-individual and inter-ethnic ...
Barker, James +5 more
core +3 more sources
Kaohsiung Journal of Medical Sciences, 2022 In the Asian general population, at least six single‐nucleotide variants (SNVs) in the UDP‐glucuronosyltransferase (UGT) 1A1 gene have been identified: −3279T>G, −53A(TA)6TAA>A(TA)7TAA, 211G>A, 686C>A, 1091C>T, and 1456T>G.
May‐Jen Huang +2 more
doaj +1 more source
Diverse biological effects of glycosyltransferase genes from Tartary buckwheat [PDF]
, 2019 Background: Tartary buckwheat (Fagopyrum tataricum) is an edible cereal crop whose sprouts have been marketed and commercialized for their higher levels of anti-oxidants, including rutin and anthocyanin. UDP-glucose flavonoid glycosyltransferases (UFGTs)
Chen, Hui +12 more
core +2 more sources
Involvement of UDP-Glucuronosyltransferases and Sulfotransferases in the Excretion and Tissue Distribution of Resveratrol in Mice. [PDF]
, 2017 Resveratrol is a naturally occurring polyphenolic compound with various pharmacological activities. It is unknown whether the expression of metabolizing enzymes correlates with resveratrol levels in organs and tissues.
Brenner, Stefan +8 more
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Ecotoxicology and Environmental Safety, 2023 UDP-glucuronosyltransferases (UGTs) could transform various exogenous and endogenous compounds, which help detoxification of pesticides in insects. To investigate the role of UGTs in the detoxification metabolism of insecticides in Chironomus kiiensis ...
Chengcheng Fan +4 more
doaj +1 more source
Renal drug metabolism in humans: the potential for drug–endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) [PDF]
, 2013 This item is under embargo for a period of 12 months from the date of publication, in accordance with the publisher's policy. ‘This is the peer reviewed version of the following article: Knights, K. M., Rowland, A. and Miners, J. O.
Knights, Kathleen Mary +2 more
core +1 more source
Effects of dietary components on testosterone metabolism via UDP‐glucuronosyltransferase (UGT)
Frontiers in Endocrinology, 2013 The potential interference in testosterone metabolism through ingested substances has ramifications for: i) a range of pathologies such as prostate cancer, ii) medication contra-indications, iii) disruption to the endocrine system, and iv) potential ...
Carl eJenkinson +2 more
doaj +1 more source