Results 11 to 20 of about 22,586 (210)

Apalutamide-Induced Hypothyroidism Associated With Increased Thyroid Hormone Clearance in Metastatic Prostate Cancer Patient: A Case Report. [PDF]

IJU Case Rep
ABSTRACT Introduction Apalutamide (APA) is an androgen receptor signaling inhibitor widely used for metastatic hormone‐sensitive prostate cancer (mHSPC), though it can induce hypothyroidism. We report a severe case of APA‐induced hypothyroidism in a patient with a history of total thyroidectomy.
Furumido J, Yamashita A, Kato R, Hori K.
europepmc   +2 more sources

Crigler-Najjar Syndrome Type 2

Journal of the Formosan Medical Association, 2006
Crigler-Najjar syndrome is a rare disorder of bilirubin metabolism with two distinct forms: type 1 and type 2. We report three patients with Crigler-Najjar syndrome type 2 (CN-2).
Ching-Shan Huang, Nancy Tan, Sien-Sing Yang, Yung-Chan Sung, May-Jen Huang   +4 more
doaj   +1 more source

Biosynthesis of hydroxyl-linked glucuronides of short-chain bile acids by rat liver 3-hydroxysteroid UDP-glucuronosyltransferase.

Journal of Lipid Research, 1988
Microsomal preparations from livers of Sprague-Dawley rats catalyze the glucuronidation of 3 alpha-hydroxy-5 beta-H (3 alpha, 5 beta) short-chain bile acids (C20-C23), predominantly at the hydroxyl group, while the glucuronidation of 3 beta, 5 beta short-
A Radominska, M D Green, P Zimniak, R Lester, T R Tephly   +4 more
doaj   +1 more source

Diverse biological effects of glycosyltransferase genes from Tartary buckwheat [PDF]

, 2019
Background: Tartary buckwheat (Fagopyrum tataricum) is an edible cereal crop whose sprouts have been marketed and commercialized for their higher levels of anti-oxidants, including rutin and anthocyanin. UDP-glucose flavonoid glycosyltransferases (UFGTs)
Chen, Hui, Deng, Renyu, Dong, Qixin, Huang, Yunji, Li, Chenglei, Li, Qi, Lv, Bingbing, Shi, Guanlan, Shi, Jiaqi, Stael, Simon, Wu, Qi, Yao, Panfeng, Zhao, Haixia   +12 more
core   +2 more sources

Bilirubin metabolism and UDP‐glucuronosyltransferase 1A1 variants in Asians: Pathogenic implications and therapeutic response

Kaohsiung Journal of Medical Sciences, 2022
In the Asian general population, at least six single‐nucleotide variants (SNVs) in the UDP‐glucuronosyltransferase (UGT) 1A1 gene have been identified: −3279T>G, −53A(TA)6TAA>A(TA)7TAA, 211G>A, 686C>A, 1091C>T, and 1456T>G.
May‐Jen Huang, Pei‐Lain Chen, Ching‐Shan Huang   +2 more
doaj   +1 more source

Involvement of UDP-Glucuronosyltransferases and Sulfotransferases in the Excretion and Tissue Distribution of Resveratrol in Mice. [PDF]

, 2017
Resveratrol is a naturally occurring polyphenolic compound with various pharmacological activities. It is unknown whether the expression of metabolizing enzymes correlates with resveratrol levels in organs and tissues.
Brenner, Stefan, Böhmdorfer, Michaela, Jäger, Walter, Riha, Juliane, Schiestl, Robert H, Szakmary, Akos, Szekeres, Thomas, Thalhammer, Theresia, Vaquero, Javier   +8 more
core   +2 more sources

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. [PDF]

, 2010
We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which ...
Aben, Katja K, Albanes, Demetrius, Allen, Naomi E, Allione, Alessandra, Andriole, Gerald, Baris, Dalsu, Benhamou, Simone, Besenbacher, Soren, Bishop, David T, Black, Amanda, Bolick, Sophia CE, Brennan, Paul, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Cancel-Tassin, Geraldine, Canzian, Federico, Caporaso, Neil, Carrato, Alfredo, Chanock, Stephen J, Chatterjee, Nilanjan, Chen, Meng, Clavel-Chapelon, Francoise, Cortessis, Victoria K, Cussenot, Olivier, Czerniak, Bogdan, D García-Prats, María, De Vivo, Immaculata, Dietrich, Holger, Dinney, Colin P, Diver, W Ryan, Figueroa, Jonine D, Fletcher, Tony, Fraumeni, Joseph F, Fu, Yi-Ping, Gago-Dominguez, Manuela, Gapstur, Susan M, Garcia-Closas, Montserrat, García-Closas, Reina, Godfrey, Ashley, Golka, Klaus, Grubb, Robert, Guarrera, Simonetta, Gurzau, Eugen, Hengstler, Jan G, Hildebrandt, Michelle AT, Hoover, Robert N, Hunter, David J, Hutchinson, Amy, Jacobs, Eric J, Jacobs, Kevin B, Johnson, Alison, Karagas, Margaret R, Kiemeney, Lambertus A, Kiltie, Anne E, Knowles, Margaret A, Kogevinas, Manolis, Koppova, Kvetoslava, Kumar, Rajiv, Landi, Maria Teresa, Ljungberg, Borje, Lloreta, Josep, Makkinje, Remco R, Malats, Nuria, Matullo, Giuseppe, Mayordomo, Jose I, McGrath, Monica, Navarro, Carmen, Panico, Salvatore, Pike, Malcolm C, Polidoro, Silvia, Porru, Stefano, Prokunina-Olsson, Ludmila, Purdue, Mark P, Rafnar, Thorunn, Real, Francisco X, Riboli, Elio, Ricceri, Fulvio, Rothman, Nathaniel, Rudnai, Peter, Sacerdote, Carlotta, Sanchez, Manuel, Sanz-Velez, José I, Schned, Alan, Schwenn, Molly, Selinski, Silvia, Serra, Consol, Silverman, Debra T, Stefansson, Kari, Stern, Mariana C, Sulem, Patrick, Tardón, Adonina, Taylor, Jack A, Teo, Mark TW, Thun, Michael, Tjonneland, Anne, Trichopoulos, Dimitrios, Valdivia, Gabriel, Van Den Berg, David, Vermeulen, Sita H, Vineis, Paolo, Virtamo, Jarmo, Wang, Zhaoming, Weinstein, Stephanie J, Wheeler, William, Witjes, J Alfred, Wu, Xifeng, Xu, Zongli, Yang, Hushan, Yeager, Meredith, Yuan, Jian-Min   +109 more
core   +2 more sources

UDP-glucuronosyltransferase is involved in susceptibility of Chironomus kiiensis Tokunaga, 1936 (Diptera: Chironomidae) to insecticides

Ecotoxicology and Environmental Safety, 2023
UDP-glucuronosyltransferases (UGTs) could transform various exogenous and endogenous compounds, which help detoxification of pesticides in insects. To investigate the role of UGTs in the detoxification metabolism of insecticides in Chironomus kiiensis ...
Chengcheng Fan, Zexiao Cui, Tianying Yang, Lili Sun, Chuanwang Cao   +4 more
doaj   +1 more source

Renal drug metabolism in humans: the potential for drug–endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) [PDF]

, 2013
This item is under embargo for a period of 12 months from the date of publication, in accordance with the publisher's policy. ‘This is the peer reviewed version of the following article: Knights, K. M., Rowland, A. and Miners, J. O.
Knights, Kathleen Mary, Miners, John Oliver, Rowland, Andrew   +2 more
core   +1 more source

Morphine Metabolism in Human Skin Microsomes [PDF]

, 2012
For patients with severe skin wounds, topically applied morphine is an option to induce efficient analgesia due to the presence of opioid receptors in the skin.
Heilmann, S., Küchler, Sarah, Schäfer-Korting, Monika   +2 more
core   +2 more sources