Results 21 to 30 of about 30,656 (311)

Bilirubin metabolism and UDP‐glucuronosyltransferase 1A1 variants in Asians: Pathogenic implications and therapeutic response

Kaohsiung Journal of Medical Sciences, 2022
In the Asian general population, at least six single‐nucleotide variants (SNVs) in the UDP‐glucuronosyltransferase (UGT) 1A1 gene have been identified: −3279T>G, −53A(TA)6TAA>A(TA)7TAA, 211G>A, 686C>A, 1091C>T, and 1456T>G.
May‐Jen Huang, Pei‐Lain Chen, Ching‐Shan Huang   +2 more
doaj   +1 more source

Potentially harmful advantage to athletes: a putative connection between UGT2B17 gene deletion polymorphism and renal disorders with prolonged use of anabolic androgenic steroids [PDF]

, 2010
: BACKGROUND AND OBJECTIVE: With prolonged use of anabolic androgenic steroids (AAS), occasional incidents of renal disorders have been observed. Independently, it has also been established that there are considerable inter-individual and inter-ethnic ...
Barker, James, Deshmukh, Nawed, Hussain, Iltaf, Naughton, Declan P, Petroczi, Andrea, Szekely, Andrea D   +5 more
core   +3 more sources

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. [PDF]

, 2010
We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which ...
Aben, Katja K, Albanes, Demetrius, Allen, Naomi E, Allione, Alessandra, Andriole, Gerald, Baris, Dalsu, Benhamou, Simone, Besenbacher, Soren, Bishop, David T, Black, Amanda, Bolick, Sophia CE, Brennan, Paul, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Cancel-Tassin, Geraldine, Canzian, Federico, Caporaso, Neil, Carrato, Alfredo, Chanock, Stephen J, Chatterjee, Nilanjan, Chen, Meng, Clavel-Chapelon, Francoise, Cortessis, Victoria K, Cussenot, Olivier, Czerniak, Bogdan, D García-Prats, María, De Vivo, Immaculata, Dietrich, Holger, Dinney, Colin P, Diver, W Ryan, Figueroa, Jonine D, Fletcher, Tony, Fraumeni, Joseph F, Fu, Yi-Ping, Gago-Dominguez, Manuela, Gapstur, Susan M, Garcia-Closas, Montserrat, García-Closas, Reina, Godfrey, Ashley, Golka, Klaus, Grubb, Robert, Guarrera, Simonetta, Gurzau, Eugen, Hengstler, Jan G, Hildebrandt, Michelle AT, Hoover, Robert N, Hunter, David J, Hutchinson, Amy, Jacobs, Eric J, Jacobs, Kevin B, Johnson, Alison, Karagas, Margaret R, Kiemeney, Lambertus A, Kiltie, Anne E, Knowles, Margaret A, Kogevinas, Manolis, Koppova, Kvetoslava, Kumar, Rajiv, Landi, Maria Teresa, Ljungberg, Borje, Lloreta, Josep, Makkinje, Remco R, Malats, Nuria, Matullo, Giuseppe, Mayordomo, Jose I, McGrath, Monica, Navarro, Carmen, Panico, Salvatore, Pike, Malcolm C, Polidoro, Silvia, Porru, Stefano, Prokunina-Olsson, Ludmila, Purdue, Mark P, Rafnar, Thorunn, Real, Francisco X, Riboli, Elio, Ricceri, Fulvio, Rothman, Nathaniel, Rudnai, Peter, Sacerdote, Carlotta, Sanchez, Manuel, Sanz-Velez, José I, Schned, Alan, Schwenn, Molly, Selinski, Silvia, Serra, Consol, Silverman, Debra T, Stefansson, Kari, Stern, Mariana C, Sulem, Patrick, Tardón, Adonina, Taylor, Jack A, Teo, Mark TW, Thun, Michael, Tjonneland, Anne, Trichopoulos, Dimitrios, Valdivia, Gabriel, Van Den Berg, David, Vermeulen, Sita H, Vineis, Paolo, Virtamo, Jarmo, Wang, Zhaoming, Weinstein, Stephanie J, Wheeler, William, Witjes, J Alfred, Wu, Xifeng, Xu, Zongli, Yang, Hushan, Yeager, Meredith, Yuan, Jian-Min   +109 more
core   +2 more sources

The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome.

New England Journal of Medicine, 1995
BACKGROUND People with Gilbert's syndrome have mild, chronic unconjugated hyperbilirubinemia in the absence of liver disease or overt hemolysis. Hepatic glucuronidating activity, essential for efficient biliary excretion of bilirubin, is reduced to about
P. Bosma, J. Chowdhury, C. Bakker, S. Gantla, A. Boer, B. Oostra, D. Lindhout, G. Tytgat, P. Jansen, R. P. Elferink, N. Chowdhury   +10 more
semanticscholar   +1 more source

SGLT-2 Inhibitors: A Novel Mechanism in Targeting Glycemic Control in Type 2 Diabetes Mellitus [PDF]

, 2016
OBJECTIVE: To review the chemistry, pharmacology, pharmacodynamics, pharmacokinetics, clinical efficacy, tolerability, dosing, drug interactions, and administration of canagliflozin, dapagliflozin, and empagliflozin, and comparing the benefit and risk ...
Ahmed-Sarwar, Nabila, Nathan, Kobi T, Werner, Paul M   +2 more
core   +2 more sources

Morphine Metabolism in Human Skin Microsomes [PDF]

, 2012
For patients with severe skin wounds, topically applied morphine is an option to induce efficient analgesia due to the presence of opioid receptors in the skin.
Heilmann, S., Küchler, Sarah, Schäfer-Korting, Monika   +2 more
core   +2 more sources

Diverse biological effects of glycosyltransferase genes from Tartary buckwheat [PDF]

, 2019
Background: Tartary buckwheat (Fagopyrum tataricum) is an edible cereal crop whose sprouts have been marketed and commercialized for their higher levels of anti-oxidants, including rutin and anthocyanin. UDP-glucose flavonoid glycosyltransferases (UFGTs)
Chen, Hui, Deng, Renyu, Dong, Qixin, Huang, Yunji, Li, Chenglei, Li, Qi, Lv, Bingbing, Shi, Guanlan, Shi, Jiaqi, Stael, Simon, Wu, Qi, Yao, Panfeng, Zhao, Haixia   +12 more
core   +2 more sources

Current trends in drug metabolism and pharmacokinetics. [PDF]

, 2019
Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion (ADME) processes of a drug. Understanding PK properties is essential for drug development and precision medication.
Abduljalil, Aghazadeh-Habashi, Aigrain, Aitman, Al Za'abi, Alegre, Alnaqeeb, Aspromonte, Babiskin, Baert, Bakke, Barnett, Bhattacharyya, Cang, Cannady, Cao, Cao, Capecchi, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Cheng, Cheng, Crawford, Currie, De Lange, Dean, Deng, Di Paolo, Dietrich, Diliberto, Dluzen, Dowling, Dragin, Dreisbach, Duan, Edeogu, Edginton, El-Arabey, El-Kadi, EMA, Eum, Falany, Fang, FDA, Feng, Feng, Feng, Ferri, Fleming, Foti, Fox, Freedman, Frye, Fukami, Gaj, Gan, Gao, Gao, Gao, Gao, Gao, Ge, Genovese, Gingell, Gingell, Gong, Graham, Gufford, Guo, Guo, Guo, Guévin, Han, Harrison, Hartz, Hasegawa, He, He, He, He, He, Ho, Ho, Hou, Hsu, Hsueh, Hu, Hu, Hu, Huo, Hwang, Ito, Jacob, Jeong, Jeong, Jia, Jian, Jiang, Jiang, Jiang, Jiang, Jilek, Jilek, Johnson, Jorga, Jung, Kaivosaari, Kalthoff, Kaminsky, Kannan, Karibe, Kesisoglou, Kim, Kim, Knights, Kong, Kota, Kumar, Kurokawa, Lai, Lan, Lanchote, Lee, Lehouritis, Li, Li, Li, Li, Li, Li, Li, Li, Li, Li, Li, Liang, Lin, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Lopes-Rodrigues, Lu, Lu, Lu, Löfgren, Mano, Marchitti, Margolskee, Martin, Matsson, Mattick, Mazerska, Mei, Mencia, Meng, Min, Mitra, Miyajima, Müller, Nair, Nakano, Nakano, Nakano, Nebert, Nguyen, Niederalt, Nieto Montesinos, Niu, Notenboom, Nozaki, Ohtsuki, Ono, Oostendorp, Pan, Pan, Papageorgiou, Papageorgiou, Park, Pea, Pedersen, Pelkonen, Pellegrino, Pettersson Bergstrand, Qi, Qin, Qiu, Qiu, Raaska, Rives, Riviere, Roberts, Robey, Rocha, Rose, Routy, Rowland, Ruwali, Saini, Satoh, Savage, Scheer, Scheer, Schlender, Schmitt, Schneider, Seitz, Showande, Shu, Shu, Shu, Shugarts, Siu, Song, Staudinger, Strong, Suarez-Sharp, Suh, Suiko, Sukkummee, Sun, Sun, Sutliff, Takeda, Tan, Tan, Tao, Tatsumi, Teorell, Tsai, Tsang, Tsuchiya, Tsume, Tu, Ulldemolins, van Waterschoot, von Richter, Vugmeyster, Vuppugalla, Wagner, Wagner, Wagner, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wassenaar, Watanabe, Wei, Wijayakumara, Wilkinson, Wong, Wu, Xia, Xie, Xie, Xu, Xu, Xu, Xu, Xu, Xue, Yamagata, Yamaguchi, Yan, Yang, Yang, Yang, Ye, Yellepeddi, Yi, Yi, Yigitaslan, Yim, Yin, Yoshida, Yoshida, Yoshimi, Yu, Yu, Yu, Yu, Yu, Yu, Yu, Zakeri-Milani, Zanger, Zeng, Zeng, Zhai, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zhao, Zhao, Zhao, Zhou, Zhou, Zhou, Zhou, Zhou, Zhu, Zhu, Zhu, Zhuang, Zimmermann   +332 more
core   +1 more source

Strong Inhibition of Celastrol Towards UDP-Glucuronosyl Transferase (UGT) 1A6 and 2B7 Indicating Potential Risk of UGT-Based Herb-Drug Interaction

Molecules, 2012
Celastrol, a quinone methide triterpene isolated from <em>Tripterygium wilfordii</em> Hook F., has various biochemical and pharmacological activities, and is now being developed as a promising anti-tumor agent.
Qi Wang, Ru-Meng Ma, Jian-Ping Deng, Gang Li, Liang Wang, Jun Yuan, Yong-Sheng Zhang, Xing-Chun Gao, Yan-Yang Tu   +8 more
doaj   +1 more source

A pharmacogenetics study of the human glucuronosyltransferase UGT1A4 [PDF]

Pharmacogenetics and Genomics, 2009
UGT1A4 is primarily expressed in the liver and exhibits catalytic activities for various drugs. Amongst the few UGT1A4 polymorphisms evaluated, studies support the alteration of UGT1A4-mediated glucuronidation by a few variations including the Pro²⁴Thr and Leu⁴⁸Val variants (referred to as UGT1A4*2 and *3).We therefore investigated genetic mechanisms ...
Benoit-Biancamano, Marie-Odile, Adam, Jean-Philippe, Bernard, Olivier, Court, Michael H, Leblanc, Marie-Hélène, Caron, Patrick, Guillemette, Chantal   +6 more
openaire   +4 more sources