Results 71 to 80 of about 22,586 (210)

Polymorphic expression of UDP-glucuronosyltransferase UGTlA gene in human colorectal cancer.

PLoS ONE, 2013
BackgroundPolymorphism of genes encoding drug-metabolizing enzymes is known to play an important role in increased susceptibility of colorectal cancer. UGT1A gene locus has been suggested to define tissue-specific glucuronidation activity.
Min Wang, De-Feng Sun, Shuai Wang, Ying Qing, Shuo Chen, Dong Wu, Ying-Min Lin, Ji-Zhuang Luo, Yan-Qing Li   +8 more
doaj   +1 more source

Traditional Chinese Medicine as an Integrative Adjunct in Oncology Perioperative Practice: Analgesia, Immune Modulation, and Translational Challenges

Medicine Bulletin, Volume 2, Issue 2, Page 184-204, March 2026.
ABSTRACT Traditional Chinese medicine (TCM), including herbal analgesic adjuvants and acupuncture‐based interventions, has gained increasing attention as an integrative strategy for perioperative pain management in oncology. Bioactive phytochemicals—such as terpenoids, flavonoids, alkaloids, and polyphenols—exert multimodal pharmacological effects ...
Yuqin Tang, Zheng Luo, Xu Zhao, Yongqiang Zhang, Mingyang Sun, Jiaqiang Zhang   +5 more
wiley   +1 more source

Biophysical characterization of the outer membrane polysaccharide export protein and the polysaccharide co-polymerase protein from Xanthomonas campestris [PDF]

, 2014
This study investigated the structural and biophysical characteristics of GumB and GumC, two Xanthomonas campestris membrane proteins that are involved in xanthan biosynthesis. Xanthan is an exopolysaccharide that is thought to be a virulence factor that
Bianco, María Isabel, Ielmini, M. V., Ielpi, Luis, Jacobs, Melisa, Salinas, Silvina Rosa, Salvay, Andrés Gerardo   +5 more
core   +1 more source

Proteome‐Wide Analysis of Human Deletions

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 3, Page 853-870, March 2026.
ABSTRACT Protein deletions are frequent among both natural and pathogenic variations. Many of them are misclassified in variation databases and the literature. Nonsense‐mediated decay prevents the expression of many nucleotide deletions. Many variants classified as protein deletions are not expressed at all.
Haoyang Zhang, Xinning Luan, Mauno Vihinen   +2 more
wiley   +1 more source

Open Systems Pharmacology Community Conference (OSP‐CC) Proceedings 2025

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT Developed at Bayer Technology Services, PK‐Sim and MoBi transitioned into the Open Systems Pharmacology (OSP) Suite, released as free open‐source software in 2017. An active community with stakeholders from academia, industries, and regulators contributes to the continuous improvement of open‐source model‐informed drug development (MIDD). This
Henrik Cordes, Pieter Annaert, Pavel Balazki, Salih Benamara, Rodolfo Hernandes Bonan, Andrew Butler, Marylore Chenel, Yunhai Cui, André Dallmann, Wilhelmus E. A. de Witte, Cleo Demeester, Denise Feick, Florence Gattacceca, René Geci, Grégori Gerebtzoff, Andrea Gruber, Mariana Guimarães, Abdullah Hamadeh, Nina Hanke, Manuel Ibarra, Ibrahim Ince, Tobias Kanacher, Lars Kuepfer, Felix Mil, Ghazal Montaseri, Nina Nauwelaerts, Susana Proenca, Stephan Schaller, Jan Frederik Schlender, Annika R. P. Schneider, Erik Sjögren, Juri Solodenko, Alexander Staab, Paul Vrenken, Carla Troisi, Donato Teutonico   +35 more
wiley   +1 more source

Insights Into Gut Barrier Dysfunction and Metabolic Alterations in Mycophenolate‐Induced Enteropathy

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
ABSTRACT Mycophenolic acid (MPA) is a widely used immunosuppressant whose use is often limited by gastrointestinal toxicity. Gut bacterial hydrolysis of liver‐derived MPA glucuronides increases local exposure to MPA, potentially impairing epithelial barrier function and cellular metabolism.
Clarisse Brossier, François‐Ludovic Sauvage, Christel Valencia‐Schmitt, Valérie Calco, Pascal Villa, Pierre Marquet, Roland Lawson   +6 more
wiley   +1 more source

Regulation of Sulfotransferase and UDP-Glucuronosyltransferase Gene Expression by the PPARs

PPAR Research, 2009
During phase II metabolism, a substrate is rendered more hydrophilic through the covalent attachment of an endogenous molecule. The cytosolic sulfotransferase (SULT) and UDP-glucuronosyltransferase (UGT) families of enzymes account for the majority of ...
Melissa Runge-Morris, Thomas A. Kocarek
doaj   +1 more source

Mechanistic studies of uridine diphosphate glucuronosyltransferase

Chemico-Biological Interactions, 1994
Bisubstrate reaction kinetics and product inhibition studies were used to characterize the kinetic mechanism of a partially purified uridine diphosphate glucuronosyltransferase (UDPGT). These studies indicate that the reaction most likely occurs via a random order sequential mechanism.
H, Yin, G, Bennett, J P, Jones
openaire   +2 more sources

Comparison of the Inhibitory Potential of Bavachalcone and Corylin against UDP-Glucuronosyltransferases [PDF]

, 2014
Bavachalcone and corylin are two major bioactive compounds isolated from Psoralea corylifolia L., which has been widely used as traditional Chinese medicine for many years.
Feng, Yujun, Qiu, Zhenyu, Shan, Lina, Shi, Xianbao, Tian, Lei, Yang, Shuman, Yuan, Hongxia, Zhang, Gang, Zhou, Dun   +8 more
core   +4 more sources

Age‐ and sex‐associated variability in lamotrigine prescription patterns and clearance

Epilepsia, Volume 67, Issue 3, Page 1256-1266, March 2026.
Abstract Objective Lamotrigine is one of the most widely prescribed antiseizure medication (ASM) and mood stabilizer in the United States due to its favorable side‐effect profile, lower risk of teratogenicity, and minimal drug–drug interactions.
Charul Avachat, Yuhan Long, Ashley Petersen, Angela K. Birnbaum, Sima I. Patel   +4 more
wiley   +1 more source