Results 71 to 80 of about 25,858 (256)

Assessment of Pharmacokinetic Drug Interaction of Asciminib with Atorvastatin in Healthy Participants

Clinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.
Abstract Asciminib is the first BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP) in patients with chronic myeloid leukemia. This phase 1, two‐treatment‐period, drug‐drug interaction study evaluated the effect of steady‐state asciminib on the pharmacokinetics of atorvastatin.
Matthias Hoch, Wendy Weis, Felix Huth, Seshulatha Jamalapuram, Michelle Quinlan, Amarnath Bandaru, Suleyman Eralp Bellibas, Asmae Mirkou, Shruti Kapoor, Shefali Kakar   +9 more
wiley   +1 more source

Gilbert’s Syndrome: Terminology, Epidemiology, Genetics, Pathogenesis (Part I)

Zdorovʹe Rebenka, 2016
The aim of the review was the analysis of the literature about the prevalence, etiology, genetics and pathogenesis of Gilbert’s syndrome (GS). The scientific literature regarding GS with the keywords «Gilbert's syndrome», «hyperbilirubinemia», «uridine ...
T.V. Sorokman, O.-M.V. Popeliuk, O.V. Makarova   +2 more
doaj   +1 more source

Análise do polimorfismo TA6/TA7 na região promotora do gene UGT1A1, em pacientes com anemia e traço falciforme de dois hospitais da cidade de Porto Alegre – RS [PDF]

, 2011
A doença de células falciformes é uma anemia hemolítica crônica de caráter autossômico recessivo, causada por uma mutação pontual no cromossomo 11. Esta mutação provoca a substituição de um ácido glutâmico por uma valina na posição seis da cadeia da ...
Antunes, Liana
core  

Rifampin modulation of xeno- and endobiotic conjugating enzyme mRNA expression and associated microRNAs in human hepatocytes [PDF]

, 2018
Rifampin is a pleiotropic inducer of multiple drug metabolizing enzymes and transporters. This work utilized a global approach to evaluate rifampin effects on conjugating enzyme gene expression with relevance to human xeno- and endo-biotic metabolism ...
Desta, Zeruesenay, Eadon, Michael T., Gao, Hongyu, Gufford, Brandon T., Lin, Hai, Liu, Yunlong, Robarge, Jason D., Skaar, Todd C.   +7 more
core   +1 more source

Dietary‐Driven Gene Expansion

Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 312-313, February 2026.
Gene duplication has been shown to drive molecular evolution, with dietary pressures expanding detoxification genes across species. In humans, CYP2D6 gene duplications enhance alkaloid and drug metabolism, reflecting ancient dietary adaptations. Similarly, tobacco‐feeding aphids amplify CYP6CY3 for nicotine and insecticide resistance, and as recently ...
Magnus Ingelman‐Sundberg
wiley   +1 more source

Regulation of Sulfotransferase and UDP-Glucuronosyltransferase Gene Expression by the PPARs

PPAR Research, 2009
During phase II metabolism, a substrate is rendered more hydrophilic through the covalent attachment of an endogenous molecule. The cytosolic sulfotransferase (SULT) and UDP-glucuronosyltransferase (UGT) families of enzymes account for the majority of ...
Melissa Runge-Morris, Thomas A. Kocarek
doaj   +1 more source

Bilirubin - Uridine Diphosphate Glucuronosyltransferase (Ugt1a1) Gene Mutations Among Newborn Babies In The Malay Population In Kelantan With Hyperbilirubinaemia [PDF]

, 2005
Sind rom Gilbert berpunca daripada keabnormalan pada gen uridine diphosphate-glucuronosyltransferase 1A 1 (UGT1A 1) yang disebabkan oleh mutasi. Mutasi-mutasi ini berbeza bagi setiap populasi dan kebanyakannya menjadi faktor asas bagi jaundis di ...
Yusoff, Surini
core  

Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells [PDF]

, 2021
Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, I. Ogawa, Shimeng Qiu, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka, Tamihide Matsunaga   +10 more
openalex   +1 more source

Intrinsic Factors Influencing Simvastatin and Simvastatin Acid Pharmacokinetics: Age‐Related Studies in Thai Adults and Cross‐Population Comparisons

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Intrinsic factors such as age and ethnicity influence statin pharmacokinetics (PK) and may increase the risk of muscle‐related adverse events. This study investigated the effect of age on the PK of simvastatin (SV) and its active metabolite, simvastatin acid (SVA), in healthy Thai subjects using an LC–MS/MS assay while accounting for key ...
Thanate Srimatimanon, Udomsak Udomnilobol, Pajaree Chariyavilaskul, Sarawut Siwamogsatham, Kearkiat Praditpornsilpa, Yongkasem Vorasettakarnkij, Aisawan Petchlorlian, Natchaya Vanwong, Jittima Piriyapongsa, Pavita Tipsombatboon, Varalee Yodsurang, Thomayant Prueksaritanont   +11 more
wiley   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, Volume 16, Issue 1, Page 199-221, January 2026.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source