Results 121 to 130 of about 3,985 (137)

GLUL Promotes Cell Proliferation in Breast Cancer.

Journal of cellular biochemistry, 2017
Glutamate-ammonia ligase (GLUL) belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. Here, we found higher expression of GLUL in the breast cancer patients was associated with larger tumor size and higher level of HER2 expression.
Yanyan, Wang, Shaohua, Fan, Jun, Lu, Zifeng, Zhang, Dongmei, Wu, Zhiyong, Wu, Yuanlin, Zheng   +6 more
openaire   +3 more sources

Glutamine Production by Glul Promotes Thermogenic Adipocyte Differentiation Through Prdm9-Mediated H3K4me3 and Transcriptional Reprogramming

Diabetes, 2023
Thermogenic adipocytes have been extensively investigated because of their energy-dissipating property and therapeutic potential for obesity and diabetes. Besides serving as fuel sources, accumulating evidence suggests that intermediate metabolites play critical roles in multiple biological processes.
Xiaowen Pan, Lingxia Ye, Xiaozhen Guo, Weihua Wang, Ziyin Zhang, Qintao Wang, Jingjing Huang, Jingya Xu, Yanhan Cai, Xinxin Shou, Yuting Wang, Yu Feng, Cen Xie, Pengfei Shan, Zhuo-Xian Meng   +14 more
openaire   +2 more sources

Functional Proteomics of Breast Cancer Metabolism Identifies GLUL as Responder during Hypoxic Adaptation

Journal of Proteome Research, 2019
Hypoxia as well as metabolism are central hallmarks of cancer, and hypoxia-inducible factors (HIFs) and metabolic effectors are crucial elements in oxygen-compromised tumor environments. Knowledge of changes in the expression of metabolic proteins in response to HIF function could provide mechanistic insights into adaptation to hypoxic stress ...
Stephan Bernhardt, Christian Tönsing, Devina Mitra, Nese Erdem, Karin Müller-Decker, Ulrike Korf, Clemens Kreutz, Jens Timmer, Stefan Wiemann   +8 more
openaire   +3 more sources

Glutamine synthetase activity and the expression of three glul paralogues in zebrafish during transport

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2012
The enzyme glutamine synthetase (GS; glutamate-ammonia ligase, EC 6.3.1.2) plays an important role in the nitrogen metabolism of fish. In this study the GS activity and the corresponding genes were examined to understand how they are regulated in zebrafish in response to hyperammonemic stress during a 72 h simulated transport. Whole body ammonia levels,
Anusha K S, Dhanasiri, Jorge M O, Fernandes, Viswanath, Kiron   +2 more
openaire   +2 more sources

Targeted Knockout of the dhfr, glul, bak1, and bax Genes by the Multiplex Genome Editing in CHO Cells

Doklady Biochemistry and Biophysics, 2022
The Chinese hamster ovary cell line CHO is widely used for biopharmaceutical production. Genome editing makes it possible to improve the growth properties of cells, their auxotrophy, and the functioning of the apoptosis and autophagy induction systems.
N A, Orlova, L K, Dayanova, E A, Gayamova, M V, Sinegubova, S V, Kovnir, I I, Vorobiev   +5 more
openaire   +2 more sources

Abstract P4-06-10: Epigenetic silencing of glutamine synthetase (Glul) defines glutamine depletion therapy

Cancer Research, 2012
Abstract Background: Methylation-dependent transcriptional silencing of genes involved in amino acid synthesis can provide potential targets for novel synthetic lethality strategies. Glutamine synthetase (Glul) is the key enzyme in the biosynthesis of glutamine.
F Cavicchioli, A Shia, K O'Leary, V Haley, TR Crook, AM Thompson, M Lackner, Nigro C Lo, P Schmid   +8 more
openaire   +1 more source

Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia

Psychiatric Genetics, 2009
As dysfunction of glutamatergic neurotransmission is one of the plausible hypotheses for the pathogenesis of schizophrenia, genes involved in the glutamate neurotransmitter system are candidates for schizophrenia susceptibility. The aim of this study is to clarify the contribution of two genes encoding glutamate metabolic enzymes: the glutamic acid ...
Shinsaku, Arai, Hiroki, Shibata, Mayumi, Sakai, Hideaki, Ninomiya, Nakao, Iwata, Norio, Ozaki, Yasuyuki, Fukumaki   +6 more
openaire   +2 more sources

Abstract 2466: Stochastic loss of GLUL expression correlates with STK11-loss-dependent glutamine addiction and may impact anti-PD1 therapy resistance in NSCLC

Cancer Research, 2021
Abstract Our work aims to delineate the molecular interactions linking somatic disruption of Serine-Threonine Kinase 11 (STK11) with anti-PD1 therapy resistance in KRAS-driven lung adenocarcinoma (LUAD). Data presented here suggests glutamine synthetase (GLUL) may modulate this phenotype.
Sean M. Lenahan, Hailey M. Sarausky, David Joseph Seward   +2 more
openaire   +1 more source

SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glutamine metabolism via enhanced GLUL

Gut
Background SIRT6 acts as a tumour suppressor in multiple cancers by regulating glucose and lipid metabolism, but its role in intrahepatic cholangiocarcinoma (ICC) remains unclear. Objective We investigated the role and molecular ...
Mi Zhang, Chanyuan Chen, Haifeng Zhang, Tanqing Long, Tingjie Wang, Nanjin Ding, Ruitao Long, Hua Wu, Zhilu Ma, Zhongyu Cheng, Junyan Tao, Dong Kuang, Lei Li, Chuanrui Xu   +13 more
openaire   +1 more source

In Silico Preliminary Association of Ammonia Metabolism Genes GLS, CPS1, and GLUL with Risk of Alzheimer’s Disease, Major Depressive Disorder, and Type 2 Diabetes

Journal of Molecular Neuroscience, 2018
Ammonia is a toxic by-product of protein catabolism and is involved in changes in glutamate metabolism. Therefore, ammonia metabolism genes may link a range of diseases involving glutamate signaling such as Alzheimer's disease (AD), major depressive disorder (MDD), and type 2 diabetes (T2D).
Griffin, Jeddidiah W.D., Liu, Ying, Bradshaw, Patrick C., Wang, Kesheng   +3 more
openaire   +3 more sources