Using TMAs (Tissue MicroArrays) to Evaluate GLS, GLUL, and CAV 1 Immunostaining in Breast Cancer [PDF]
, 2016 poster abstractApproximately 1 out of 8 women in the United States will develop invasive breast cancer over the course of their lifetime. Breast cancer has a greater potential of being cured if diagnosed in the earlier phases.
Finnearty, Courtney +3 more
core +1 more source
Inside the genome: understanding genetic influences on oxidative stress
Frontiers in GeneticsGenetics is a key factor that governs the susceptibility to oxidative stress. In the body, oxidative burden is regulated by the balance between the prooxidant genes that orchestrate processes that produce oxidant species, while the antioxidant genes aid ...
Hari Krishnan Krishnamurthy +7 more
doaj +2 more sources
Microenvironmental G protein-coupled estrogen receptor-mediated glutamine metabolic coupling between cancer-associated fibroblasts and triple-negative breast cancer cells governs tumour progression. [PDF]
Clin Transl MedBackground Triple‐negative breast cancer (TNBC) is a particularly aggressive type of breast cancer, known for its lack of effective treatments and unfavorable prognosis. The G protein‐coupled estrogen receptor (GPER), a novel estrogen receptor, is linked
He C +13 more
europepmc +2 more sources
Underlying mechanisms of phosphodiesterase 10A and glutamate-ammonia ligase genes that regulate inosine monophosphate deposition and thereby affect muscle tenderness in Jingyuan chickens [PDF]
Animal Bioscience, 2022 Objective Inosine monophosphate (IMP) is a key factor that imparts of meat flavor. Differences in the IMP content in the muscles were evaluated to improve chicken meat quality.
Weizhen Wang +8 more
doaj +1 more source
Glutamine synthetase in human carotid plaque macrophages associates with features of plaque vulnerability : An immunohistological study [PDF]
, 2022 Publisher Copyright: © 2022 The AuthorsBackground and aims: Glutamine synthetase (GLUL), the sole generator of glutamine, is a metabolic nexus molecule also involved in atherosclerosis.
Ijäs, Petra +9 more
core +1 more source
Low-frequency variants in genes involved in glutamic acid metabolism and γ-glutamyl cycle and risk of coronary artery disease in type 2 diabetes. [PDF]
Cardiovasc DiabetolBackground A common genetic variant at the glutamate-ammonia ligase (GLUL) locus has been previously associated with an increased risk of coronary artery disease (CAD) as well as alterations of glutamic acid metabolism and the γ-glutamyl cycle in ...
Giuffrida FMA +8 more
europepmc +2 more sources
Mendelian randomization analysis of plasma proteins reveals potential novel tumor markers for gastric cancer. [PDF]
Sci RepThis study aimed to elucidate the potential causal relationship between 4,907 plasma proteins and the risk of gastric cancer using a two-sample Mendelian randomization approach.
Fan W +5 more
europepmc +2 more sources
T Helper Cell Activation and Expansion Is Sensitive to Glutaminase Inhibition under Both Hypoxic and Normoxic Conditions. [PDF]
PLoS ONE, 2016 Immune responses often take place where nutrients and O2 availability are limited. This has an impact on T cell metabolism and influences activation and effector functions.
Zeynep Sener +4 more
doaj +1 more source
AMPK Activation in TET2 Downregulated Leukemia Cells Upon Glutamine Limitation. [PDF]
Medeni Med JObjective: Metabolic rewiring is a characteristic of cancer cells. Cancer cells require more nutrients for survival and proliferation. Although glutamine can be produced in cells via a series of enzymatic reactions, a group of cancer cells are dependent ...
Bayrak AM, Yucel B.
europepmc +2 more sources
Identification of common mechanisms and biomarkers of atrial fibrillation and heart failure based on machine learning. [PDF]
ESC Heart FailAims Atrial fibrillation (AF) is the most common arrhythmia. Heart failure (HF) is a disease caused by heart dysfunction. The prevalence of AF and HF were progressively increasing over time.
Zhang Z +9 more
europepmc +2 more sources