Results 31 to 40 of about 3,985 (137)

Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism

Cell Reports, 2019
Summary: Glutamine is thought to play an important role in cancer cells by being deaminated via glutaminolysis to α-ketoglutarate (aKG) to fuel the tricarboxylic acid (TCA) cycle. Supporting this notion, aKG supplementation can restore growth/survival of
Alex J. Bott, Jianliang Shen, Claudia Tonelli, Le Zhan, Nithya Sivaram, Ya-Ping Jiang, Xufen Yu, Vrushank Bhatt, Eric Chiles, Hua Zhong, Sara Maimouni, Weiwei Dai, Stephani Velasquez, Ji-An Pan, Nathiya Muthalagu, Jennifer Morton, Tracy G. Anthony, Hui Feng, Wouter H. Lamers, Daniel J. Murphy, Jessie Yanxiang Guo, Jian Jin, Howard C. Crawford, Lanjing Zhang, Eileen White, Richard Z. Lin, Xiaoyang Su, David A. Tuveson, Wei-Xing Zong   +28 more
doaj   +1 more source

Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts. [PDF]

PLoS ONE, 2014
The detoxification of ammonia occurs mainly through conversion of ammonia to urea in the liver via the urea cycle and glutamine synthesis. Congenital portosystemic shunts (CPSS) in dogs cause hyperammonemia eventually leading to hepatic encephalopathy ...
Giora van Straten, Frank G van Steenbeek, Guy C M Grinwis, Robert P Favier, Anne Kummeling, Ingrid H van Gils, Hille Fieten, Marian J A Groot Koerkamp, Frank C P Holstege, Jan Rothuizen, Bart Spee   +10 more
doaj   +1 more source

Investigating the role of GLUL as a survival factor in cellular adaptation to glutamine depletion via targeted stable isotope resolved metabolomics [PDF]

Frontiers in Molecular Biosciences, 2022
Cellular glutamine synthesis is thought to be an important resistance factor in protecting cells from nutrient deprivation and may also contribute to drug resistance. The application of ‟targeted stable isotope resolved metabolomics” allowed to directly measure the activity of glutamine synthetase in the cell.
Șafak Bayram, Yasmin Sophiya Razzaque, Sabrina Geisberger, Matthias Pietzke, Matthias Pietzke, Susanne Fürst, Susanne Fürst, Carolina Vechiatto, Martin Forbes, Guido Mastrobuoni, Stefan Kempa   +10 more
openaire   +3 more sources

A fluorescence-coupled assay for gamma aminobutyric acid (GABA) reveals metabolic stress-induced modulation of GABA content in neuroendocrine cancer. [PDF]

PLoS ONE, 2014
Pathways involved in the synthesis of the neurotransmitter gamma-aminobutyric acid (GABA) have been implicated in the pathogenesis of high grade neuroendocrine (NE) neoplasms as well as neoplasms from a non-NE lineage.
Joseph E Ippolito, David Piwnica-Worms
doaj   +1 more source

Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival [PDF]

Journal of Cancer Research and Clinical Oncology, 2021
Abstract Purpose Glutamine plays an important role in cell viability and growth of various tumors. For the fetal subtype of hepatoblastoma, growth inhibition through glutamine depletion was shown. We studied glutamine depletion in embryonal cell lines of hepatoblastoma carrying different mutations.
Andreas Schmidt, Angela Armento, Ovidio Bussolati, Martina Chiu, Verena Ellerkamp, Marcus O. Scharpf, Philip Sander, Evi Schmid, Steven W. Warmann, Jörg Fuchs   +9 more
openaire   +4 more sources

Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis

Adipocyte, 2021
Objectives Adipocytes and adipocyte lipid metabolism are closely related with obesity and type 2 diabetes, but the molecular mechanism still needs further investigation.
Zhiyong Dong, Xinyi Lei, Stacy A. Kujawa, NaciEmre Bolu, Hong Zhao, Cunchuan Wang   +5 more
doaj   +1 more source

GLUL Ablation Can Confer Drug Resistance to Cancer Cells via a Malate-Aspartate Shuttle-Mediated Mechanism [PDF]

Cancers, 2019
Glutamate-ammonia ligase (GLUL) is important for acid-base homeostasis, ammonia detoxification, cell signaling, and proliferation. Here, we reported that GLUL ablation conferred resistance to several anticancer drugs in specific cancer cell lines while leaving other cell lines non-resistant to the same drugs.
Magesh Muthu, Ranjeet Kumar, Azharuddin Sajid Syed Khaja, Jonathan D. Gilthorpe, Jenny L. Persson, Anders Nordström   +5 more
openaire   +4 more sources

Astrocyte Bioenergetic Remodeling as a Central Trait of Disrupted Glucocorticoid Signaling: Mechanisms and Implications for Stress Vulnerability. [PDF]

J Neurochem
Low/brief glucocorticoid (GC) elevations can enhance mitochondrial output (↑ oxygen consumption rate, OCR; ↑ mitochondrial membrane potential, ΔΨm) and Ca2+ buffering, in part via glucocorticoid receptor (GR) trafficking to mitochondria in complexes with Bcl2 and Bag1.
Hanus P, Frydecka D, Ślęzak M.
europepmc   +2 more sources

MicroRNA-140-5p suppresses invasion and proliferation of glioma cells by targeting glutamate-ammonia ligase (GLUL)

Neoplasma, 2020
Glutamine addiction is a major feature of glioma cells and plays an important role in its growth and proliferation. GLUL (glutamate-ammonia ligase), which catalyzes glutamate and ammonia to synthesize glutamine, plays a crucial role in tumor growth and proliferation.
R, Zhang, J C, Zhu, H, Hu, Q Y, Lin, W, Shao, T H, Ji   +5 more
openaire   +3 more sources

Leukemia Cells Resistant to Glutamine Deprivation Express Glutamine Synthetase Protein

Turkish Journal of Hematology, 2022
Objective: Low glutamine levels have been shown in tumor environments for several cancer subtypes. Therefore, it has been suggested that cancer cells rewire their metabolism to adopt low nutrient levels for survival and proliferation.
Burcu Yücel, Saniye Ada
doaj   +1 more source