Results 31 to 40 of about 7,531 (182)

FISH mapping of three ammonia metabolism genes (Glul, Cps1, Glud1) in rat, and the chromosomal localization of GLUL in human and Cps1 in mouse [PDF]

Mammalian Genome, 1997
In recent years, the rat genes encoding glutamate dehydrogenase (GLUD; Das et al. 1993), glutamine synthetase (glutamateammonia ligase, GLUL; van de Zande et al. 1990) and carbamoylphosphate synthetase 1 (CPS; Van den Hoff et al. 1995) have been isolated.
Khalil Helou, Atze T. Das, Wouter H. Lamers, J.M.N. Hoovers, C. Szpirer, Josiane Szpirer, Karin Klinga‐Levan, Göran Levan   +7 more
semanticscholar   +6 more sources

Bioinformatics-based study on the regulatory network of lipid metabolism-related genes and mechanisms in coronary heart disease [PDF]

Hereditas
Coronary heart disease (CHD), is a complex cardiovascular disease driven by atherosclerosis, resulting from a dynamic interplay between dysregulated lipid metabolism and chronic inflammation.
Zunxiong Xiao, Liping Wang, Haoqing Shao, Xiaoying Tian, Qinfang Zheng, Xudong Li   +5 more
doaj   +2 more sources

Specific inhibition of glutamine synthase involved in the metabolic pathway of amino acids is associated with anti-arthritic effects of sinomenine hydrochloride [PDF]

Frontiers in Cell and Developmental Biology
Sinomenine (SIN) is the key bioactive alkaloid isolated from Sinomenium acutum which has been prescribed commonly in Chinese medicine for managing rheumatic disorders.
Gejing Li, Gejing Li, Zhaoli Su, Yuanyuan Tang, Hong Huang, Junlan Zhang, Ye Lin, Qin Zhang, Xiong Cai, Xiong Cai   +9 more
doaj   +2 more sources

Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts. [PDF]

PLoS ONE, 2014
The detoxification of ammonia occurs mainly through conversion of ammonia to urea in the liver via the urea cycle and glutamine synthesis. Congenital portosystemic shunts (CPSS) in dogs cause hyperammonemia eventually leading to hepatic encephalopathy ...
Giora van Straten, Frank G van Steenbeek, Guy C M Grinwis, Robert P Favier, Anne Kummeling, Ingrid H van Gils, Hille Fieten, Marian J A Groot Koerkamp, Frank C P Holstege, Jan Rothuizen, Bart Spee   +10 more
doaj   +8 more sources

Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction [PDF]

Frontiers in Immunology
BackgroundPreeclampsia, a hypertensive disorder during pregnancy affecting 2-8% of pregnancies globally, remains a leading cause of maternal and fetal morbidity.
Jingjing Chen, Dan Zhang, Chengxiu Zhu, Lin Lin, Kejun Ye, Ying Hua, Mengjia Peng   +6 more
doaj   +2 more sources

Ion channels and atrial fibrillation: mitophagy as a key mediator [PDF]

Frontiers in Physiology
BackgroundThe prevalence of atrial fibrillation (AF) is increasing due to the aging population. Mitophagy is crucial for maintaining cardiomyocyte function, while ion channels play a key role in cardiac electrical activity.
Xize Wu, Xiaorui Yan, Ruoxi Ma, Qiuying Wu, Xue Pan, Qihua Wu, Jiaqi Ren, Yuxi Huang, Shan Gao, Yue Li, Lihong Gong   +10 more
doaj   +2 more sources

Microenvironmental G protein‐coupled estrogen receptor‐mediated glutamine metabolic coupling between cancer‐associated fibroblasts and triple‐negative breast cancer cells governs tumour progression [PDF]

Clinical and Translational Medicine
Background Triple‐negative breast cancer (TNBC) is a particularly aggressive type of breast cancer, known for its lack of effective treatments and unfavorable prognosis. The G protein‐coupled estrogen receptor (GPER), a novel estrogen receptor, is linked
Chongwu He, Meixi Peng, Xiaoqiang Zeng, Hanzhi Dong, Zhengkui Sun, Jiawei Xu, Manran Liu, Liyan Liu, Yanxiao Huang, Zhiqiang Peng, Yu‐An Qiu, Chunling Jiang, Bin Xu, Tenghua Yu   +13 more
doaj   +2 more sources

Targeting AQP5-mediated arginine deprivation in gastric cancer stem cells restores NK cell anti-tumor immunity [PDF]

Cell Reports Medicine
Summary: Natural killer (NK) cells exhibit impaired anti-tumor activity upon entering the tumor microenvironment (TME); however, the precise mechanism(s) remains elusive.
Rou Zhao, Baoyu He, Lunhua Huang, Yanli Wu, Ting Liu, Jilan Liu, Mingsheng Zhao, Tao Zhong, Yanhua Zhang, Xiao Zhang, Huabao Xiong, Bin Zhang, Qingli Bie   +12 more
doaj   +2 more sources

Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration [PDF]

Bone Research
Intervertebral disc degeneration (IDD) is a progressive and dynamic process in which the senescence-associated secretory phenotype (SASP) of nucleus pulposus cells (NPC) plays a significant role. While impaired chaperone-mediated autophagy (CMA) has been
Zhangrong Cheng, Haiyang Gao, Pengzhi Shi, Anran Zhang, Xianglong Chen, Yuhang Chen, Weikang Gan, Kangcheng Zhao, Shuai Li, Cao Yang, Yukun Zhang   +10 more
doaj   +2 more sources

Sequence of E. coli tRNA^Glulby automated sequential degradation

Nucleic Acids Research, 1975
Mayo Uziel, Alycia J. Weinberger
openalex   +4 more sources