Results 41 to 50 of about 3,985 (137)
Genome‐wide association analysis identifies a GLUL haplotype for familial hepatitis B virus‐related hepatocellular carcinoma [PDF]
Cancer, 2017 BACKGROUNDA family history of liver cancer increases the risk of developing hepatocellular carcinoma (HCC) by 2‐fold to 10‐fold among patients with chronic hepatitis B virus (HBV). Previous genome‐wide association studies have identified many possible susceptible loci associated with sporadic HBV‐related HCC.
You‐Yu Lin +6 more
openaire +2 more sources
Open Medicine, 2023 Acute myeloid leukemia (AML) is classified into favorable-risk, intermediate-risk, and poor-risk subtypes. This study aimed to compare the serum proteomic signatures of the three AML subtypes and identify prognostic biomarkers for AML. Serum samples from
Zhang Wei, Liu Bei, Wu Shiwen, Zhao Li
doaj +1 more source
Molecular Metabolism, 2022 Objective: Dicer is an enzyme that processes microRNAs (miRNAs) precursors into mature miRNAs, which have been implicated in various aspects of cancer progressions, such as clinical aggressiveness, prognosis, and survival outcomes.
Ji Min Park +10 more
doaj +1 more source
Neurobiology of Disease, 2006 Mild cognitive impairment (MCI) is generally referred to the transitional zone between normal cognitive function and early dementia or clinically probable Alzheimer's disease (AD).
D. Allan Butterfield +6 more
doaj +1 more source
Molecular Oncology, 2023 An immunosuppressive state is regulated by various factors in the tumor microenvironment (TME), including, but not limited to, metabolic plasticity of immunosuppressive cells and cytokines secreted by these cells.
Jinfen Wei +8 more
doaj +1 more source
Frontiers in Microbiology, 2022 Endo-β-1,4-glucanase is a crucial glycoside hydrolase (GH) involved in the decomposition of cellulosic materials. In this study, to discover a novel cold-adapted β-1,4-D-glucan-degrading enzyme, the gene coding for an extracellular endo-β-1,4-glucanase ...
Do Young Kim +8 more
doaj +1 more source
PO-249 GLUL knockdown induces drug resistance in non-small cell lung cancer cells
ESMO Open, 2018 ABSTRACT Introduction Chemotherapy has advanced well in the treatment of Non-Small Cell Lung Cancers (NSCLCs), but its effectiveness is limited by drug resistance. Unfortunately, cancer drug resistance becoming inevitable involving alterations in epigenetic regulation, molecular signalling, and metabolic rewiring.
M. Muthu, A. Nordstrom
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Advanced Science, EarlyView.Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang +12 more
wiley +1 more source
Frontiers in Molecular Neuroscience, 2023 Astrocytes play an important role in the pathogenesis of Alzheimer’s disease (AD). It is widely involved in energy metabolism in the brain by providing nutritional and metabolic support to neurons; however, the alteration in the metabolism of astrocytes ...
Li-Yuan Fan +13 more
doaj +1 more source
Nucleosides, Nucleotides & Nucleic Acids, 2022 The central function of telomerase is maintaining the telomere length. However, several extra-telomeric roles have been identified for this protein complex. In this study, we evaluated the effect of the silencing of the catalytic subunit of telomerase (TERT) on the expression of candidate microRNAs, cell activation markers and glial-related genes in a ...
Yeimy González-Giraldo +2 more
openaire +2 more sources