Every Hilbert space frame has a Naimark complement [PDF]
, 2013 Naimark complements for Hilbert space Parseval frames are one of the most fundamental and useful results in the field of frame theory. We will show that actually all Hilbert space frames have Naimark complements which possess all the usual properties for
Casazza, Peter G. +4 more
core +10 more sources
Prognostic signature and therapeutic drug identification for dilated cardiomyopathy based on necroptosis via bioinformatics and experimental validation. [PDF]
Sci RepNecroptosis, a type of programmed cell death, has been increasingly linked to cardiovascular disease development, yet its role in dilated cardiomyopathy (DCM) remains unclear.
Yang H +5 more
europepmc +2 more sources
Genomic and Phenotypic Characterization of CHO 4BGD Cells with Quad Knockout and Overexpression of Two Housekeeping Genes That Allow for Metabolic Selection and Extended Fed-Batch Culturing. [PDF]
CellsRe-engineering of CHO cells using genome editing and the overexpression of multiple helper genes is the central track for obtaining better cell lines for the production of biopharmaceuticals.
Orlova NA +5 more
europepmc +2 more sources
A fluorescence-coupled assay for gamma aminobutyric acid (GABA) reveals metabolic stress-induced modulation of GABA content in neuroendocrine cancer. [PDF]
PLoS ONE, 2014 Pathways involved in the synthesis of the neurotransmitter gamma-aminobutyric acid (GABA) have been implicated in the pathogenesis of high grade neuroendocrine (NE) neoplasms as well as neoplasms from a non-NE lineage.
Joseph E Ippolito, David Piwnica-Worms
doaj +1 more source
Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis
Adipocyte, 2021 Objectives Adipocytes and adipocyte lipid metabolism are closely related with obesity and type 2 diabetes, but the molecular mechanism still needs further investigation.
Zhiyong Dong +5 more
doaj +1 more source
Leukemia Cells Resistant to Glutamine Deprivation Express Glutamine Synthetase Protein
Turkish Journal of Hematology, 2022 Objective: Low glutamine levels have been shown in tumor environments for several cancer subtypes. Therefore, it has been suggested that cancer cells rewire their metabolism to adopt low nutrient levels for survival and proliferation.
Burcu Yücel, Saniye Ada
doaj +1 more source
Oligodendroglioma cells lack glutamine synthetase and are auxotrophic for glutamine, but do not depend on glutamine anaplerosis for growth [PDF]
, 2018 In cells derived from several types of cancer, a transcriptional program drives high consumption of glutamine (Gln), which is used for anaplerosis, leading to a metabolic addiction for the amino acid. Low or absent expression of Glutamine Synthetase (GS),
Andreoli, Roberta +8 more
core +2 more sources
cpt1b Regulates Cardiomyocyte Proliferation Through Modulation of Glutamine Synthetase in Zebrafish. [PDF]
J Cardiovasc Dev DisCarnitine palmitoyltransferase 1b (Cpt1b) is a crucial rate-limiting enzyme in fatty acid metabolism, but its role and mechanism in early cardiac development remains unclear. Here, we show that cpt1b regulates cardiomyocyte proliferation during zebrafish
Cheng X, Ju J, Huang W, Duan Z, Han Y.
europepmc +2 more sources
Open Medicine, 2023 Acute myeloid leukemia (AML) is classified into favorable-risk, intermediate-risk, and poor-risk subtypes. This study aimed to compare the serum proteomic signatures of the three AML subtypes and identify prognostic biomarkers for AML. Serum samples from
Zhang Wei, Liu Bei, Wu Shiwen, Zhao Li
doaj +1 more source
Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster? [PDF]
, 2019 Distinct from normal differentiated tissues, cancer cells reprogram nutrient uptake and utilization to accommodate their elevated demands for biosynthesis and energy production.
Jiang, Jie +2 more
core +1 more source