Results 61 to 70 of about 6,846 (179)

Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human

, 2019
The Hedgehog (Hh) and Wnt/β-Catenin (Wnt) cascades are morphogen pathways whose pronounced influence on adult liver metabolism has been identified in recent years.
Aleithe, S., Brosch, M., Brusch, L., Damm, G., Gajowski, R., Gebhardt, R., Hampe, J., Hoehme, S., Hoffmann, U., Kolbe, E., Kücken, M., Matz-Soja, M., Meierhofer, D., Ott, F., Rennert, C., Schafmayer, C., Seehofer, D., Seifert, M., Spormann, L., Stöpel, C., von Schoenfels, W.   +20 more
core   +1 more source

Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids. [PDF]

, 2016
AIMS: An intergenic locus on chromosome 1 (lead SNP rs10911021) was previously associated with coronary heart disease (CHD) in type 2 diabetes (T2D). Using data from the UCLEB consortium we investigated the relationship between rs10911021 and CHD in T2D,
Ala-Korpela, Mika, Beaney, Katherine E, Ben-Shlomo, Yoav, Cooper, Jackie A, Drenos, Fotios, Hardy, Rebecca, Humphries, Steve E, Jefferis, Barbara J, Kangas, Antti J, Kivimaki, Mika, Kuh, Diana, Kumari, Meena, McLachlan, Stela, Ong, Ken, Price, Jacqueline F, Soininen, Pasi, UCLEB consortium, Wannamethee, S Goya, Whincup, Peter, Wong, Andrew   +19 more
core   +7 more sources

Increased NMDARs in neurons and glutamine synthetase in astrocytes underlying autistic-like behaviors of Gabrb1−/− mice

iScience, 2023
Summary: Mutations of the GABA-A receptor subunit β1 (GABRB1) gene are found in autism patients. However, it remains unclear how mutations in Gabrb1 may lead to autism. We generated Gabrb1−/− mouse model, which showed autistic-like behaviors.
Jing Wang, Yue Gao, Liuyan Xiao, Yanmei Lin, Lang Huang, Jinfa Chen, Guanmei Liang, Weiming Li, Wenjuan Yi, Jianpei Lao, Bin Zhang, Tian-Ming Gao, Mei Zhong, Xinping Yang   +13 more
doaj  

Quantitative Comparative Proteomics Reveal Biomarkers for Dengue Disease Severity

Frontiers in Microbiology, 2019
Dengue fever (DF) could develop into dengue haemorrhagic fever (DHF) with increased mortality rate. Since the clinical characteristics and pathogen are same in DF and DHF.
Lifen Han, Xiulan Ao, Shujin Lin, Shengcan Guan, Lin Zheng, Xiao Han, Hanhui Ye   +6 more
doaj   +1 more source

Gene transfer engineering for astrocyte-specific silencing in the CNS. [PDF]

, 2015
Cell-type-specific gene silencing is critical to understand cell functions in normal and pathological conditions, in particular in the brain where strong cellular heterogeneity exists.
Delzor, A., Dufour, N., Déglon, N., Hantraye, P., Merienne, N., Rey, M., Viret, A.   +6 more
core   +1 more source

CAFs targeted ultrasound-responsive nanodroplets loaded V9302 and GLULsiRNA to inhibit melanoma growth via glutamine metabolic reprogramming and tumor microenvironment remodeling

Journal of Nanobiotechnology, 2023
Despite rapid advances in metabolic therapies over the past decade, their efficacy in melanoma has been modest, largely due to the interaction between cancer-associated fibroblasts (CAFs) and cancer cells to promote cancer growth.
Chen Ai, Xiao Sun, Shan Xiao, Lu Guo, Mengmeng Shang, Dandan Shi, Dong Meng, Yading Zhao, Xiaoxuan Wang, Jie Li   +9 more
doaj   +1 more source

Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression. [PDF]

, 2011
Several studies have proposed that brain glutamate signaling abnormalities and glial pathology have a role in the etiology of major depressive disorder (MDD).
Akil, H, Barchas, JD, Bernard, R, Bunney, WE, Jones, EG, Kerman, IA, Myers, RM, Schatzberg, AF, Thompson, RC, Watson, SJ   +9 more
core  

Novel Methodology for Creating Macaque Retinas with Sortable Photoreceptors and Ganglion Cells [PDF]

, 2016
Purpose: The ability to generate macaque retinas with sortable cell populations would be of great benefit to both basic and translational studies of the primate retina.
C. Douglas Witherspoon, Christianne E. Strang, Daniel T. Kasuga, John J. Alexander, Julie Lynch Hill, Miranda L. Scalabrino, Paul D. Gamlin, Sanford L. Boye, Shannon E. Boye, Shreyasi Choudhury   +9 more
core   +2 more sources

RepliChrom: Interpretable machine learning predicts cancer‐associated enhancer‐promoter interactions using DNA replication timing

iMeta, EarlyView.
RepliChrom is an interpretable machine learning model that predicts enhancer‐promoter interactions using DNA replication timing across multiple cell types. By integrating replication timing with chromatin interaction data from multiple experimental platforms, it accurately distinguishes true interactions and reveals promoter‐region signals as key ...
Fuying Dao, Benjamin Lebeau, Crystal Chia Yin Ling, Mi Yang, Xueqin Xie, Melissa Jane Fullwood, Hao Lin, Hao Lyu   +7 more
wiley   +1 more source

Mind the GAPS: Glia associated with psychological stress

Journal of Neuroendocrinology, EarlyView.
Abstract Glial cells are an integral component of the nervous system, performing crucial functions that extend beyond structural support, including modulation of the immune system, tissue repair, and maintaining tissue homeostasis. Recent studies have highlighted the importance of glial cells as key mediators of stress responses across different organs.
Niklas Blank, Molly Weiner, Shaan Patel, Sarah Köhler, Christoph A. Thaiss   +4 more
wiley   +1 more source