Results 61 to 70 of about 3,985 (137)

Comment on The Look AHEAD Research Group. Prospective Association of GLUL rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study. Diabetes 2016;65:297–302 [PDF]

Diabetes, 2016
The Look AHEAD (Action for Health in Diabetes) Research Group (1) found that the C allele for rs10911021 was closely related to the primary composite end point of cardiovascular death and that intensive lifestyle intervention did not affect this correlation.
Haiyu, Tang, Chuanyu, Gao
openaire   +2 more sources

Response to Comment on The Look AHEAD Research Group. Prospective Association of GLUL rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study. Diabetes 2016;65:297–302 [PDF]

Diabetes, 2016
We thank Drs. Tang and Gao for their letter (1) in response to our article (2) describing the association of rs10911021 with cardiovascular disease (CVD) in overweight/obese participants with type 2 diabetes in the the Look AHEAD (Action for Health in Diabetes) trial.
Jeanne M, McCaffery, Gordon S, Huggins
openaire   +2 more sources

Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton, Nur Jury‐Garfe, Jiahui Liu, Caleb Beimfohr, Chitra Sunil, Steven Brooks, Pengyue Zhang, Sean D. McCabe, Timothy I. Richardson, Kun Huang, Cristian A. Lasagna‐Reeves, Jie Zhang, Travis S. Johnson   +12 more
wiley   +1 more source

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

MedComm, Volume 7, Issue 2, February 2026.
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao, Xiaojie Qu, Yiqi Wang, Dan Huang, Huiling Zhang, Mingyuan Dong, Han Sun, Zhaogang Yang, Xuefeng Li   +8 more
wiley   +1 more source

CAFs targeted ultrasound-responsive nanodroplets loaded V9302 and GLULsiRNA to inhibit melanoma growth via glutamine metabolic reprogramming and tumor microenvironment remodeling

Journal of Nanobiotechnology, 2023
Despite rapid advances in metabolic therapies over the past decade, their efficacy in melanoma has been modest, largely due to the interaction between cancer-associated fibroblasts (CAFs) and cancer cells to promote cancer growth.
Chen Ai, Xiao Sun, Shan Xiao, Lu Guo, Mengmeng Shang, Dandan Shi, Dong Meng, Yading Zhao, Xiaoxuan Wang, Jie Li   +9 more
doaj   +1 more source

Acrolein Promotes Retinal Inflammation Through Macrophage Chemotaxis by Inducing CCL2 Production From Müller Cells

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Patients with proliferative diabetic retinopathy show elevated vitreous levels of the acrolein adduct FDP‐lys and CCL2. In rat Müller glial cells (TR‐MUL5), acrolein increases Ccl2 gene expression and CCL2 secretion and promotes macrophage migration.
Kanae Fukutsu, Miyuki Murata, Kasumi Kikuchi, Kousuke Noda, Susumu Ishida   +4 more
wiley   +1 more source

Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Four distinct satellite glial cell subtypes are identified in mouse dorsal root ganglia using single‐cell RNA sequencing and spatial validation. These subtypes show unique marker profiles and anatomical distributions. Human dorsal root ganglia display layered perisomatic organization with differential marker expression.
Ole Andreas Ahlgreen, Mads Würgler Hansen, Jonas Baake, Thomas Engelbrecht Hybel, Rachele Rossi, Xin Lai, Ishwarya Sankaranarayanan, Johanne Amalie Pold, Lin Lin, Line Reinert, Søren Riis Paludan, Theodore John Price, Lone Tjener Pallesen, Christian Bjerggaard Vægter   +13 more
wiley   +1 more source

Low-frequency variants in genes involved in glutamic acid metabolism and γ-glutamyl cycle and risk of coronary artery disease in type 2 diabetes

Cardiovascular Diabetology
Background A common genetic variant at the glutamate-ammonia ligase (GLUL) locus has been previously associated with an increased risk of coronary artery disease (CAD) as well as alterations of glutamic acid metabolism and the γ-glutamyl cycle in ...
Fernando M. A. Giuffrida, Sharan K. Rai, Yaling Tang, Christine Mendonça, Scott G. Frodsham, Hetal S. Shah, Marcus G. Pezzolesi, Qi Sun, Alessandro Doria   +8 more
doaj   +1 more source

A Pan‐Subtype Fatty Acid Metabolic Signature Reveals Universal Prognostic Stratification in Breast Cancer

Cancer Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background Breast cancer exhibits profound molecular heterogeneity. Each subtype is characterized by distinct biological features, therapeutic responses, and prognostic outcomes. However, a unifying feature across most breast cancer subtypes is an adipocyte‐enriched microenvironment.
Yunjian Song, Jiayue Li, Meiyue Zhu, Yi Xia, Deqiang Wang, Zhenhua Sun, Liang Ou, Lei Yang   +7 more
wiley   +1 more source

HIF1α and HIF2α exert distinct nutrient preferences in renal cells.

PLoS ONE, 2014
BackgroundHypoxia Inducible Factors (HIF1α and HIF2α) are commonly stabilized and play key roles related to cell growth and metabolic programming in clear cell renal cell carcinoma.
Alexandra Arreola, C Lance Cowey, Jonathan L Coloff, Jeffrey C Rathmell, W Kimryn Rathmell   +4 more
doaj   +1 more source