Results 61 to 70 of about 7,531 (182)

Single‐cell and spatial analyses reveal the association between gene expression of glutamine synthetase with the immunosuppressive phenotype of APOE+CTSZ+TAM in cancers

Molecular Oncology, 2023
An immunosuppressive state is regulated by various factors in the tumor microenvironment (TME), including, but not limited to, metabolic plasticity of immunosuppressive cells and cytokines secreted by these cells.
Jinfen Wei, Wenqi Yu, Juanzhi Chen, Guanda Huang, Lingjie Zhang, Zixi Chen, Meiling Hu, Xiaocheng Gong, Hongli Du   +8 more
doaj   +1 more source

Phosphomimetic Dicer S1016E triggers a switch to glutamine metabolism in gemcitabine-resistant pancreatic cancer

Molecular Metabolism, 2022
Objective: Dicer is an enzyme that processes microRNAs (miRNAs) precursors into mature miRNAs, which have been implicated in various aspects of cancer progressions, such as clinical aggressiveness, prognosis, and survival outcomes.
Ji Min Park, Jei-Ming Peng, Yu-Shiuan Shen, Chia-Ying Lin, Tung-Wei Hsu, Yen-Hao Su, Hsin-An Chen, Charupong Saengboonmee, Jung-Su Chang, Ching-Feng Chiu, Yan-Shen Shan   +10 more
doaj   +1 more source

Gene transfer engineering for astrocyte-specific silencing in the CNS. [PDF]

, 2015
Cell-type-specific gene silencing is critical to understand cell functions in normal and pathological conditions, in particular in the brain where strong cellular heterogeneity exists.
Delzor, A., Dufour, N., Déglon, N., Hantraye, P., Merienne, N., Rey, M., Viret, A.   +6 more
core   +1 more source

Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: Insights into the development of Alzheimer's disease

Neurobiology of Disease, 2006
Mild cognitive impairment (MCI) is generally referred to the transitional zone between normal cognitive function and early dementia or clinically probable Alzheimer's disease (AD).
D. Allan Butterfield, H. Fai Poon, Daret St. Clair, Jeffery N. Keller, William M. Pierce, Jon B. Klein, William R. Markesbery   +6 more
doaj   +1 more source

Novel, acidic, and cold-adapted glycoside hydrolase family 8 endo-β-1,4-glucanase from an Antarctic lichen-associated bacterium, Lichenicola cladoniae PAMC 26568

Frontiers in Microbiology, 2022
Endo-β-1,4-glucanase is a crucial glycoside hydrolase (GH) involved in the decomposition of cellulosic materials. In this study, to discover a novel cold-adapted β-1,4-D-glucan-degrading enzyme, the gene coding for an extracellular endo-β-1,4-glucanase ...
Do Young Kim, Jonghoon Kim, Yung Mi Lee, Soo Min Byeon, Soo Min Byeon, Jeong Hae Gwak, Jong Suk Lee, Dong-Ha Shin, Ho-Yong Park   +8 more
doaj   +1 more source

Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids. [PDF]

, 2016
AIMS: An intergenic locus on chromosome 1 (lead SNP rs10911021) was previously associated with coronary heart disease (CHD) in type 2 diabetes (T2D). Using data from the UCLEB consortium we investigated the relationship between rs10911021 and CHD in T2D,
Ala-Korpela, Mika, Beaney, Katherine E, Ben-Shlomo, Yoav, Cooper, Jackie A, Drenos, Fotios, Hardy, Rebecca, Humphries, Steve E, Jefferis, Barbara J, Kangas, Antti J, Kivimaki, Mika, Kuh, Diana, Kumari, Meena, McLachlan, Stela, Ong, Ken, Price, Jacqueline F, Soininen, Pasi, UCLEB consortium, Wannamethee, S Goya, Whincup, Peter, Wong, Andrew   +19 more
core   +8 more sources

TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer. [PDF]

, 2016
A subgroup of breast cancers has several metabolic compartments. The mechanisms by which metabolic compartmentalization develop in tumors are poorly characterized. TP53 inducible glycolysis and apoptosis regulator (TIGAR) is a bisphosphatase that reduces
Bartrons, Ramon, Birbe, Ruth C., Capparelli, Claudia, Caro, Jaime, Curry, Joseph M., Domingo-Vidal, Marina, Ko, Ying-Hui, Lin, Zhao, Manzano, Anna, Martinez-Outshoorn, Ubaldo E., Navarro-Sabaté, Àurea, Roche, Megan, Seifert, Erin, Tassone, Patrick, Tuluc, Madalina, Whitaker-Menezes, Diana   +15 more
core   +2 more sources

Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human

, 2019
The Hedgehog (Hh) and Wnt/β-Catenin (Wnt) cascades are morphogen pathways whose pronounced influence on adult liver metabolism has been identified in recent years.
Aleithe, S., Brosch, M., Brusch, L., Damm, G., Gajowski, R., Gebhardt, R., Hampe, J., Hoehme, S., Hoffmann, U., Kolbe, E., Kücken, M., Matz-Soja, M., Meierhofer, D., Ott, F., Rennert, C., Schafmayer, C., Seehofer, D., Seifert, M., Spormann, L., Stöpel, C., von Schoenfels, W.   +20 more
core   +1 more source

Target Identification Reveals Glul Lactylation as a Key Mechanism for Dioscin-Induced Ferroptosis in Bortezomib-Resistant Myeloma

Y. F. Lyu, Guangchao Li, Xiaoting Zhang, Qi Zhong, Zhi Liu, Ruiming Ou, Huijuan Shen, Jing Huang, Shaya Mahati, Yangmin Zhu, Qing Zhang, Shuang Liu, Yin Zhao   +12 more
openalex   +2 more sources

Single-nucleus transcriptional profiling uncovers the reprogrammed metabolism of astrocytes in Alzheimer’s disease

Frontiers in Molecular Neuroscience, 2023
Astrocytes play an important role in the pathogenesis of Alzheimer’s disease (AD). It is widely involved in energy metabolism in the brain by providing nutritional and metabolic support to neurons; however, the alteration in the metabolism of astrocytes ...
Li-Yuan Fan, Li-Yuan Fan, Li-Yuan Fan, Jing Yang, Ming-Li Li, Ming-Li Li, Ruo-Yu Liu, Ruo-Yu Liu, Ying Kong, Su-Ying Duan, Guang-Yu Guo, Guang-Yu Guo, Jing-Hua Yang, Yu-Ming Xu   +13 more
doaj   +1 more source