Results 71 to 80 of about 6,846 (179)

The Use of Cell-penetrating Peptide for Delivery of Recombinant Transcription Factor DNA into Primary Human Fibroblast

MCBS (Molecular and Cellular Biomedical Sciences), 2023
Background: Reprogrammed cell therapy has not been applied for clinical purposes due to the malignancy issue. The aim of this study was to design the recombinant vector of the transcription factors and analyze the effectiveness of cell-penetrating ...
Melinda Remelia, Budiman Bela, Silvia Tri Widyaningtyas, Radiana Dhewayani Antarianto, Nuzli Fahdia Mazfufah, Jeanne Adiwinata Pawitan   +5 more
doaj   +1 more source

Temporal Profiling of Male Cortical Astrocyte Transcription Predicts Molecular Shifts From Early Development to Aging

Glia, Volume 73, Issue 7, Page 1349-1364, July 2025.
Main Points Comprehensive analysis of cortical astrocyte gene expression across the lifespan. Profiling dynamic changes of key astrocyte genes reveals functional shifts. Astrocytes contribute to gene‐length‐dependent transcription decline in the aging brain.
Xiaoran Wei, Jiangtao Li, Michelle L. Olsen   +2 more
wiley   +1 more source

Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late‐Onset Alzheimer's Disease

Glia, Volume 73, Issue 6, Page 1166-1187, June 2025.
Main Points Generation and characterization of iPSC‐derived astrocytes from 44 aged humans. Congruence of gene expression profiles between astrocyte cultures and brain. Association of interferon response proteins with AD pathology resilience. ABSTRACT Reactive astrocytes are associated with Alzheimer's disease (AD), and several AD genetic risk variants
Hyo Lee, Richard V. Pearse II, Alexandra M. Lish, Cheryl Pan, Zachary M. Augur, Gizem Terzioglu, Pallavi Gaur, Meichen Liao, Masashi Fujita, Earvin S. Tio, Duc M. Duong, Daniel Felsky, Nicholas T. Seyfried, Vilas Menon, David A. Bennett, Philip L. De Jager, Tracy L. Young‐Pearse   +16 more
wiley   +1 more source

Haptoglobin and Glutamine Synthetase May Biomark Cachexia Induced by Antiacute Myeloid Leukaemia Chemotherapy

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 3, June 2025.
ABSTRACT Background Anticancer chemotherapy is an underappreciated contributor to cancer cachexia, an often‐irreversible body‐wasting condition that causes 20%–30% of cancer‐related deaths. An obstacle to predicting, monitoring and understanding the mechanisms underlying chemotherapy cachexia is that each cancer (and subtype) is assigned different ...
Dean G. Campelj, Cara A. Timpani, Guinevere Spiesberger, Luke E. Formosa, Joel R. Steele, Haijian Zhang, Ralf B. Schittenhelm, Lewis Leow, Craig A. Goodman, Emma Rybalka   +9 more
wiley   +1 more source

Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism

Cell Reports, 2019
Summary: Glutamine is thought to play an important role in cancer cells by being deaminated via glutaminolysis to α-ketoglutarate (aKG) to fuel the tricarboxylic acid (TCA) cycle. Supporting this notion, aKG supplementation can restore growth/survival of
Alex J. Bott, Jianliang Shen, Claudia Tonelli, Le Zhan, Nithya Sivaram, Ya-Ping Jiang, Xufen Yu, Vrushank Bhatt, Eric Chiles, Hua Zhong, Sara Maimouni, Weiwei Dai, Stephani Velasquez, Ji-An Pan, Nathiya Muthalagu, Jennifer Morton, Tracy G. Anthony, Hui Feng, Wouter H. Lamers, Daniel J. Murphy, Jessie Yanxiang Guo, Jian Jin, Howard C. Crawford, Lanjing Zhang, Eileen White, Richard Z. Lin, Xiaoyang Su, David A. Tuveson, Wei-Xing Zong   +28 more
doaj  

TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer. [PDF]

, 2016
A subgroup of breast cancers has several metabolic compartments. The mechanisms by which metabolic compartmentalization develop in tumors are poorly characterized. TP53 inducible glycolysis and apoptosis regulator (TIGAR) is a bisphosphatase that reduces
Bartrons, Ramon, Birbe, Ruth C., Capparelli, Claudia, Caro, Jaime, Curry, Joseph M., Domingo-Vidal, Marina, Ko, Ying-Hui, Lin, Zhao, Manzano, Anna, Martinez-Outshoorn, Ubaldo E., Navarro-Sabaté, Àurea, Roche, Megan, Seifert, Erin, Tassone, Patrick, Tuluc, Madalina, Whitaker-Menezes, Diana   +15 more
core   +2 more sources

Metabolomics in cardiometabolic diseases: Key biomarkers and therapeutic implications for insulin resistance and diabetes

Journal of Internal Medicine, Volume 297, Issue 6, Page 584-607, June 2025.
Abstract Cardiometabolic diseases—including Type 2 diabetes and obesity—remain leading causes of global mortality. Recent advancements in metabolomics have facilitated the identification of metabolites that are integral to the development of insulin resistance, a characteristic feature of cardiometabolic disease. Key metabolites, such as branched‐chain
David Rizo‐Roca, John D. Henderson, Juleen R. Zierath   +2 more
wiley   +1 more source

Enhanced PDMS Functionalization for Organ‐on‐a‐Chip Platforms Using Ozone and Sulfo‐SANPAH: A Simple Approach for Biomimetic Long‐Term Cell Cultures

Advanced Healthcare Materials, Volume 14, Issue 13, May 16, 2025.
The use of organ‐on‐a‐chip (OOC) microfluidic platforms is expanding in biomedical research. While this emerging technology is becoming increasingly accessible, the stability of long‐term functional cultures remains a critical challenge to address. This study presents a straightforward, one‐step method for the functionalization of polydimethylsiloxane ...
Mitzi Pérez‐Calixto, Cindy Peto‐Gutiérrez, Alyssa Shapiro, Lazaro Huerta, Mathieu Hautefeuille, Marina Macías‐Silva, Daniel Pérez‐Calixto, Genaro Vázquez‐Victorio   +7 more
wiley   +1 more source

Phosphomimetic Dicer S1016E triggers a switch to glutamine metabolism in gemcitabine-resistant pancreatic cancer

Molecular Metabolism, 2022
Objective: Dicer is an enzyme that processes microRNAs (miRNAs) precursors into mature miRNAs, which have been implicated in various aspects of cancer progressions, such as clinical aggressiveness, prognosis, and survival outcomes.
Ji Min Park, Jei-Ming Peng, Yu-Shiuan Shen, Chia-Ying Lin, Tung-Wei Hsu, Yen-Hao Su, Hsin-An Chen, Charupong Saengboonmee, Jung-Su Chang, Ching-Feng Chiu, Yan-Shen Shan   +10 more
doaj  

Multi-Omic Profiling, Structural Characterization, and Potent Inhibitor Screening of Evasion-Related Proteins of a Parasitic Nematode, Haemonchus contortus, Surviving Vaccine Treatment

Biomedicines, 2023
The emergence of drug-resistant parasitic nematodes in both humans and livestock calls for development of alternative and cost-effective control strategies.
Nikola Palevich, Paul H. Maclean, Vincenzo Carbone, Ruy Jauregui, Saleh Umair   +4 more
doaj   +1 more source