Results 71 to 80 of about 3,985 (137)

Spatial Transcriptional Heterogeneity in the Infarct Core and Its Surrounding Regions Targeting Piezo1 Signals in Rats With Myocardial Ischemia‐Reperfusion Injury

MedComm, Volume 7, Issue 1, January 2026.
We employed spatially resolved transcriptomics to visualize and molecularly characterize the spatial distribution of gene expression profiles in the rats’ left ventricles following MIR injury. Further experiments indicated that cardiogenic Piezo1‐mediated calcium overload exacerbates MIR through the activation of matrix metalloproteinase 2‐ryanodine ...
Zhen Li, Fan Jiang, Yan Chen, Zhixiao Li, Yanqiong Wu, Zhigang He, Duozhi Wu, Hongbing Xiang   +7 more
wiley   +1 more source

Neurons in a Dish: A Review of In Vitro Cell Models for Studying Neurogenesis

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Different in vitro cell models are valuable to study the different steps of neurogenesis, from the proliferation of neural stem and progenitor cells to the maturation of neurons. Pluripotent stem cells (including embryonic stem cells and induced pluripotent stem cells), immortalized human neuroblastoma cell lines (SH‐SY5Y, IMR‐32), and primary brain ...
Mariana Vassal, Ana C. Cruz, Sandra Rebelo, Filipa Martins   +3 more
wiley   +1 more source

Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment

Journal of Neuroinflammation, 2019
Background Extracellular vesicles (EVs) are nano-sized particles present in most body fluids including cerebrospinal fluid (CSF). Little is known about CSF EV proteins in HIV+ individuals.
Debjani Guha, David R. Lorenz, Vikas Misra, Sukrutha Chettimada, Susan Morgello, Dana Gabuzda   +5 more
doaj   +1 more source

<b>Glutamine production by Glul promotes thermogenic adipocyte differentiation through Prdm9-mediated H3K4me3 and transcriptional </b><b>reprogram</b><b>ming</b>

, 2023
<p><b>Abstract</b><br>Thermogenic adipocytes have been extensively investigated due to their energy dissipating property and therapeutic potential for obesity and diabetes. Besides serving as fuel sources, accumulating evidence suggests that intermediate metabolites play critical roles in multiple biological processes.
Zhuo-Xian Meng, Pengfei Shan, Cen Xie, Yu Feng, Yuting Wang, Xinxin Shou, Yanhan Cai, Jingya Xu, Jingjing Huang, Qintao Wang, Ziyin Zhang, Weihua Wang, Xiaozhen Guo, Lingxia Ye, Xiaowen Pan   +14 more
openaire   +1 more source

AMPK Activation in TET2 Downregulated Leukemia Cells Upon Glutamine Limitation

Medeniyet Medical Journal
Objective: Metabolic rewiring is a characteristic of cancer cells. Cancer cells require more nutrients for survival and proliferation. Although glutamine can be produced in cells via a series of enzymatic reactions, a group of cancer cells are dependent ...
Ahsen Merve BAYRAK, Burcu YUCEL
doaj   +1 more source

Chromosomal Mapping of a Family of Human Glutamine Synthetase Genes: Functional Gene (GLUL) on 1q25, Pseudogene (GLULP) on 9p13, and Three Related Genes (GLULL1, GLULL2, GLULL3) on 5q33, 11p15, and 11q24

Genomics, 1996
Glutamine synthetase (GS) is a ubiquitous enzyme that catalyzes the ATP-dependent conversion of glutamate to glutamine using ammonia as the nitrogen source. Using human GS cDNA as a probe, a bacterial artificial chromosome (BAC) library consisting of two-fold coverage of the human genome was screened, and 18 clones were obtained.
Y, Wang, J, Kudoh, R, Kubota, S, Asakawa, S, Minoshima, N, Shimizu   +5 more
openaire   +2 more sources

m6A RNA methyltransferase METTL16 induces Cr(VI) carcinogenesis and lung cancer development through glutamine biosynthesis and GLUL expression

Journal of Hazardous Materials
Hexavalent chromium [Cr(VI)] exposure increases the risk of cancer occurrence. This study found that the levels of an atypical methyltransferase, METTL16 were greatly upregulated in the cells, and mouse tissues with Cr(VI) exposure, and played a critical role in cell proliferation and tumor growth induced by Cr(VI).
Yun-Xia, Xie, Lin, Wang, Zhi-Hao, Zhou, Wen-Jing, Liu, Wei, Wang, Jing-Hua, Yang, Ming-Liang, He, Jian-Ge, Qiu, Bing-Hua, Jiang   +8 more
openaire   +2 more sources

cpt1b Regulates Cardiomyocyte Proliferation Through Modulation of Glutamine Synthetase in Zebrafish

Journal of Cardiovascular Development and Disease
Carnitine palmitoyltransferase 1b (Cpt1b) is a crucial rate-limiting enzyme in fatty acid metabolism, but its role and mechanism in early cardiac development remains unclear. Here, we show that cpt1b regulates cardiomyocyte proliferation during zebrafish
Xiaohan Cheng, Jingyi Ju, Wenping Huang, Zongyi Duan, Yanchao Han   +4 more
doaj   +1 more source

Neuroprotective effects of L-Dopa-modified zinc oxide nanoparticles on the rat model of 6-OHDA-ınduced Parkinson’s disease

Scientific Reports
Parkinson’s disease (PD) is a chronic neurodegenerative case. As the disease progresses, the response time to doses of levodopa (L-Dopa) becomes shorter and the effects of the drug are severely limited by some undesirable side effects such as the ‘on–off’
Yesim Yeni, Sıdıka Genc, Muhammed Sait Ertugrul, Hayrunnisa Nadaroglu, Arzu Gezer, Ali Sefa Mendil, Ahmet Hacımuftuoglu   +6 more
doaj   +1 more source

Mendelian randomization analysis of plasma proteins reveals potential novel tumor markers for gastric cancer

Scientific Reports
This study aimed to elucidate the potential causal relationship between 4,907 plasma proteins and the risk of gastric cancer using a two-sample Mendelian randomization approach.
Wenhai Fan, Zhenjiang Wu, Shenghao Xu, Zhiheng Liu, Yiming Huang, Pan Wang   +5 more
doaj   +1 more source