Results 11 to 20 of about 17,873 (207)

MicroRNA-140-5p suppresses invasion and proliferation of glioma cells by targeting glutamate-ammonia ligase (GLUL)

Neoplasma, 2020
Glutamine addiction is a major feature of glioma cells and plays an important role in its growth and proliferation. GLUL (glutamate-ammonia ligase), which catalyzes glutamate and ammonia to synthesize glutamine, plays a crucial role in tumor growth and proliferation.
J C Zhu, Q Y Lin, W Shao, R Zhang, H Hu, T H Ji, T H Ji   +6 more
openaire   +5 more sources

Glutamate-ammonia ligase promotes lung cancer cell growth through an enzyme-independent upregulation of CaMK2G under a glutamine-sufficient condition [PDF]

bioRxiv, 2019
SUMMARYGlutamate-ammonia ligase (GLUL) is highly expressed in many cancer cells. Synthesizing glutamine by its enzyme function has been found to be important for supporting cancer cell survival and growth under glutamine restriction. However, GLUL’s functions under a glutamine-sufficient condition still have not been uncovered.
Zhao, Jiangsha, Zeng, Xiankun, Hou, Steven X.   +2 more
openaire   +3 more sources

C-Terminal Part of Glutamate-Ammonia-Ligase Adenyltransferase Gene Identified by RAPD-HRM with 3H Primer for E. Coli Screening

Folia Biologica, 2019
A single random oligonucleotide 3H primer has been previously applied in random-amplified- polymorphic-DNA (RAPD)-PCR to distinguish stocked bacteria E. coli within a cocktail mixture also containing Enterococcus faecalis, Bifidobacterium longum and Ruminococcus gnavus.
Y C, Chen, Y S, Lai, D J H, Shyu, Y W, Chang, Z R, Chen, Y K, Liao, C T, Pang, K T, Chang   +7 more
openaire   +3 more sources

Astroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy

Frontiers in Neurology, 2021
The enzyme glutamine synthetase (GS), also referred to as glutamate ammonia ligase, is abundant in astrocytes and catalyzes the conversion of ammonia and glutamate to glutamine.
Mani Ratnesh S. Sandhu, Benjamin F. Gruenbaum, Shaun E. Gruenbaum, Roni Dhaher, Ketaki Deshpande, Melissa C. Funaro, Tih-Shih W. Lee, Hitten P. Zaveri, Tore Eid   +8 more
doaj   +2 more sources

LncRNA OIP5-AS1 Knockdown Targets miR-183-5p/GLUL Axis and Inhibits Cell Proliferation, Migration and Metastasis in Nasopharyngeal Carcinoma

Frontiers in Oncology, 2022
Nasopharyngeal carcinoma (NPC) is often associated with the infection of Epstein-Barr virus in nasopharynx and is mainly happened in South China and Southeast Asia. Recently, noncoding RNAs have been reported to regulate NPC carcinogenesis.
Shuo Li, Shuo Li, Mingxing Tang, Nan Zen, Nan Zen, Junyi Liang, Junyi Liang, Xiao Xing, Xiao Xing, Danglin Huang, Danglin Huang, Fei Liu, Fei Liu, Xiaomeng Zhang   +13 more
doaj   +2 more sources

GLUL gene knockdown and restricted glucose level show synergistic inhibitory effect on the luminal subtype breast cancer MCF7 cells’ proliferation and metastasis

EXCLI Journal : Experimental and Clinical Sciences, 2023
The glutamine synthetase path is one of the most important metabolic pathways in luminal breast cancer cells, which plays a critical role in supplying glutamine as an intermediate in the biosynthesis of amino acids and nucleotides.
Arezu Karimpur Zahmatkesh, Mohammad Khalaj-Kondori, Mohammad Ali Hosseinpour Feizi, Behzad Baradaran   +3 more
doaj   +2 more sources

Genome-Wide Characterization of Glutamine Synthetase Family Genes in Cucurbitaceae and Their Potential Roles in Cold Response and Rootstock-Scion Signaling Communication

Agriculture, 2021
Glutamine synthetase (GS; EC 6.3.1.2, L-glutamate: ammonia ligase ADP-forming) is the key enzyme responsible for the primary assimilation and reassimilation of nitrogen (N) in higher plants.
Xiaojun Li, Xiaohong Lu, Mengshuang Liu, Chenggang Xiang, Wenqian Liu, Cuicui Wang, Xiaojing Zhang, Tao Wang, Zixi Liu, Lihong Gao, Wenna Zhang   +10 more
doaj   +2 more sources

Effect of Adenosine Triphosphate Treatment on Quality Maintenance of Fresh-Cut Cucumber [PDF]

Shipin Kexue, 2023
Adenosine triphosphate (ATP) treatment effects on the quality maintenance of fresh-cut cucumber and the contents of bioactive compounds such as total phenolic and γ-aminobutyric acid (GABA) in fresh-cut cucumber were studied.
CHEN Yiting, TANG Jing, MENG Xianwei, WANG Chunfei, JIN Peng, ZHENG Yonghua
doaj   +1 more source

The Use of Cell-penetrating Peptide for Delivery of Recombinant Transcription Factor DNA into Primary Human Fibroblast

MCBS (Molecular and Cellular Biomedical Sciences), 2023
Background: Reprogrammed cell therapy has not been applied for clinical purposes due to the malignancy issue. The aim of this study was to design the recombinant vector of the transcription factors and analyze the effectiveness of cell-penetrating ...
Melinda Remelia, Budiman Bela, Silvia Tri Widyaningtyas, Radiana Dhewayani Antarianto, Nuzli Fahdia Mazfufah, Jeanne Adiwinata Pawitan   +5 more
doaj   +1 more source

Astrocyte glutamine synthetase : pivotal in health and disease [PDF]

, 2013
The multifunctional properties of astrocytes signify their importance in brain physiology and neurological function. In addition to defining the brain architecture, astrocytes are primary elements of brain ion, pH and neurotransmitter homoeostasis.
Parpura, Vladimir, Rose, Christopher, Verkhratsky, Alexei   +2 more
core   +1 more source