The Distinctive Regulation of Cyanobacterial Glutamine Synthetase [PDF]
, 2018 Glutamine synthetase (GS) features prominently in bacterial nitrogen assimilation as it catalyzes the entry of bioavailable nitrogen in form of ammonium into cellular metabolism. The classic example, the comprehensively characterized GS of enterobacteria,
Bolay, Paul +3 more
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Cell Reports, 2019 Summary: Glutamine is thought to play an important role in cancer cells by being deaminated via glutaminolysis to α-ketoglutarate (aKG) to fuel the tricarboxylic acid (TCA) cycle. Supporting this notion, aKG supplementation can restore growth/survival of
Alex J. Bott +28 more
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Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]
, 2011 <p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Aparicio, I. +7 more
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Gene expression changes in the septum: possible implications for microRNAs in sculpting the maternal brain. [PDF]
PLoS ONE, 2012 The transition from the non-maternal to the maternal state is characterized by a variety of CNS alterations that support the care of offspring. The septum (including lateral and medial portions) is a brain region previously linked to various emotional ...
Changjiu Zhao +3 more
doaj +1 more source
Adaptive remodeling of the bacterial proteome by specific ribosomal modification regulates Pseudomonas infection and niche colonisation [PDF]
, 2016 Post-transcriptional control of protein abundance is a highly important, underexplored regulatory process by which organisms respond to their environments.
A Brencic +83 more
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Reduced glutamine synthetase activity alters the fecundity of female Bactrocera dorsalis (Hendel) [PDF]
, 2019 Glutamine synthetase (GS) is a key enzyme in glutamine synthesis and is associated with multiple physiological processes in insects, such as embryonic development, heat shock response, and fecundity regulation.
Smagghe, Guy +5 more
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Disruption of Mitochondrial Dynamics and Integrity Drives Divergent Metabolic Flexibility and Resilience in Podocytes. [PDF]
FASEB JWe investigated two models of mitochondrial dysfunction in podocytes, using two cell culture models: podocytes isolated from mice with Oma1 deletion (Oma1del) and mouse podocytes modified with an inducible knockdown of PHB2 (Phb2kd). OMA1 deficiency induced a glycolytic shift, enhanced glutamine anaplerosis, and sustained energy homeostasis after ...
Özel C +13 more
europepmc +2 more sources
Astrocyte glutamine synthetase : pivotal in health and disease [PDF]
, 2013 The multifunctional properties of astrocytes signify their importance in brain physiology and neurological function. In addition to defining the brain architecture, astrocytes are primary elements of brain ion, pH and neurotransmitter homoeostasis.
Parpura, Vladimir +2 more
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Ecological functions of uncultured microorganisms in the cobalt-rich ferromanganese crust of a seamount in the central Pacific are elucidated by fosmid sequencing [PDF]
, 2014 Author Posting. © The Author(s), 2014. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution.
Cheng, Hong +7 more
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The Journal of Poultry Science, 2006 It has been known that glutamine synthetase (GS, L-glutamate ammonia ligase) is an enzyme that catalyzes ATP-dependent condensation of glutamate and ammonia to form glutamine, and that GS and growth hormone (GH) are proteins that are induced by ...
Nobuyuki Shirasawa +4 more
doaj +1 more source