The Urea Carboxylase and Allophanate Hydrolase Activities of Urea Amidolyase Are Functionally Independent [PDF]
, 2016 Urea amidolyase (UAL) is a multifunctional biotin-dependent enzyme that contributes to both bacterial and fungal pathogenicity by catalyzing the ATP-dependent cleavage of urea into ammonia and CO2.
Bahler +48 more
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The Distinctive Regulation of Cyanobacterial Glutamine Synthetase [PDF]
, 2018 Glutamine synthetase (GS) features prominently in bacterial nitrogen assimilation as it catalyzes the entry of bioavailable nitrogen in form of ammonium into cellular metabolism. The classic example, the comprehensively characterized GS of enterobacteria,
Bolay, Paul +3 more
core +1 more source
Cell Reports, 2019 Summary: Glutamine is thought to play an important role in cancer cells by being deaminated via glutaminolysis to α-ketoglutarate (aKG) to fuel the tricarboxylic acid (TCA) cycle. Supporting this notion, aKG supplementation can restore growth/survival of
Alex J. Bott +28 more
doaj +1 more source
PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma
Science Advances, 2023 For clear cell renal cell carcinoma (ccRCC), lipid deposition plays important roles in the development, metastasis, and drug resistance. However, the molecular mechanisms underlying lipid deposition in ccRCC remain largely unknown.
Song Peng +18 more
semanticscholar +1 more source
Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]
, 2011 <p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Aparicio, I. +7 more
core +4 more sources
Gene expression changes in the septum: possible implications for microRNAs in sculpting the maternal brain. [PDF]
PLoS ONE, 2012 The transition from the non-maternal to the maternal state is characterized by a variety of CNS alterations that support the care of offspring. The septum (including lateral and medial portions) is a brain region previously linked to various emotional ...
Changjiu Zhao +3 more
doaj +1 more source
Adaptive remodeling of the bacterial proteome by specific ribosomal modification regulates Pseudomonas infection and niche colonisation [PDF]
, 2016 Post-transcriptional control of protein abundance is a highly important, underexplored regulatory process by which organisms respond to their environments.
A Brencic +83 more
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International Journal of Medical Sciences, 2023 Although adjuvant tamoxifen therapy is beneficial to estrogen receptor-positive (ER+) breast cancer patients, a significant number of patients still develop metastasis or undergo recurrence.
Do Thi Minh Xuan +7 more
semanticscholar +1 more source
Astrocyte glutamine synthetase : pivotal in health and disease [PDF]
, 2013 The multifunctional properties of astrocytes signify their importance in brain physiology and neurological function. In addition to defining the brain architecture, astrocytes are primary elements of brain ion, pH and neurotransmitter homoeostasis.
Parpura, Vladimir +2 more
core +1 more source
Reduced glutamine synthetase activity alters the fecundity of female Bactrocera dorsalis (Hendel) [PDF]
, 2019 Glutamine synthetase (GS) is a key enzyme in glutamine synthesis and is associated with multiple physiological processes in insects, such as embryonic development, heat shock response, and fecundity regulation.
Smagghe, Guy +5 more
core +2 more sources