Results 21 to 30 of about 17,873 (207)

The Urea Carboxylase and Allophanate Hydrolase Activities of Urea Amidolyase Are Functionally Independent [PDF]

, 2016
Urea amidolyase (UAL) is a multifunctional biotin-dependent enzyme that contributes to both bacterial and fungal pathogenicity by catalyzing the ATP-dependent cleavage of urea into ammonia and CO2.
Bahler, Baker, Balotra, Bratlie, Chapman-Smith, Chen, Chen, Cheng, Dumetz, Fan, Fan, Geck, Ghosh, Greenberg, Hettwer, Huang, Ianeselli, James, Kaessmann, Kanamori, Kanamori, Khosla, Kimura, Koonin, Kotlyar, Kozer, Kulkarni, Kulkarni, Kuriyan, Lawrence, Lherbet, Lietzan, Lin, Lorenz, Marsh, Moxley, Navarathna, Navarathna, Ribeiro, Shapir, Shapir, Singh, Spivey, Strope, Thanabalu, Thoden, Thompson, Whitney, Zeczycki   +48 more
core   +2 more sources

Gene expression changes in the septum: possible implications for microRNAs in sculpting the maternal brain. [PDF]

PLoS ONE, 2012
The transition from the non-maternal to the maternal state is characterized by a variety of CNS alterations that support the care of offspring. The septum (including lateral and medial portions) is a brain region previously linked to various emotional ...
Changjiu Zhao, Michael C Saul, Terri Driessen, Stephen C Gammie   +3 more
doaj   +1 more source

Tau affects P53 function and cell fate during the DNA damage response [PDF]

Communications Biology 3, 245 (2020), 2020
Cells are constantly exposed to DNA damaging insults. To protect the organism, cells developed a complex molecular response coordinated by P53, the master regulator of DNA repair, cell division and cell fate. DNA damage accumulation and abnormal cell fate decision may represent a pathomechanism shared by aging-associated disorders such as cancer and ...
arxiv   +1 more source

The Distinctive Regulation of Cyanobacterial Glutamine Synthetase [PDF]

, 2018
Glutamine synthetase (GS) features prominently in bacterial nitrogen assimilation as it catalyzes the entry of bioavailable nitrogen in form of ammonium into cellular metabolism. The classic example, the comprehensively characterized GS of enterobacteria,
Bolay, Paul, Florencio Bellido, Francisco Javier, Klähn, Stephan, Muro Pastor, María Isabel   +3 more
core   +1 more source

Exploring PROTAC cooperativity with coarse-grained alchemical methods [PDF]

, 2022
Proteolysis targeting chimera (PROTAC) is a novel drug modality that facilitates the degradation of a target protein by inducing proximity with an E3 ligase. In this work, we present a new computational framework to model the cooperativity between PROTAC-E3 binding and PROTAC-target binding principally through protein-protein interactions (PPIs ...
arxiv   +1 more source

Runaway Transition in Irreversible Polymer Condensation with Cyclisation [PDF]

, 2022
The process of polymer condensation, i.e. the formation of bonds between reactive end-groups, is ubiquitous in both industry and biology. Here we study generic systems undergoing polymer condensation in competition with cyclisation. Using a generalised Smoluchowski theory, molecular dynamics simulations and experiments using DNA and T4 ligase, we find ...
arxiv   +1 more source

The glutaminase-dependent acid resistance system. Qualitative and quantitative assays and analysis of its distribution in enteric bacteria [PDF]

, 2018
Neutralophilic bacteria have developed several strategies to overcome the deleterious effects of acid stress. In particular, the amino acid-dependent systems are widespread, with their activities overlapping, covering a rather large pH range, from 6 to
DE BIASE, Daniela, D’Alonzo, Chiara, Freddi, Luca, Occhialini, Alessandra, Pennacchietti, Eugenia   +4 more
core   +13 more sources

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]

, 2011
<p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Aparicio, I., Engel, P.C., Llinas, M., Muller, S., Olszewski, K., Patzewitz, E.-M., Perner, J., Storm, J.   +7 more
core   +4 more sources

PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma

Science Advances, 2023
For clear cell renal cell carcinoma (ccRCC), lipid deposition plays important roles in the development, metastasis, and drug resistance. However, the molecular mechanisms underlying lipid deposition in ccRCC remain largely unknown.
Song Peng, Ze Wang, Peng Tang, Shuo Wang, Yiqiang Huang, Qiubo Xie, Yapeng Wang, Xintao Tan, T. Tang, Xuzhi Yan, Jing Xu, W. Lan, Luofu Wang, Dianzheng Zhang, Bin Wang, T. Pan, Jun Qin, Jun Jiang, Qiuli Liu   +18 more
semanticscholar   +1 more source

Glucocorticoid-Inducible Glutamine Synthetase in GH Cells of Chick Embryos, Gallus domesticus: Ontogeny of Glutamine Synthetase, GH, and Pit-1 Protein in the Pituitary Gland

The Journal of Poultry Science, 2006
It has been known that glutamine synthetase (GS, L-glutamate ammonia ligase) is an enzyme that catalyzes ATP-dependent condensation of glutamate and ammonia to form glutamine, and that GS and growth hormone (GH) are proteins that are induced by ...
Nobuyuki Shirasawa, Ying-Jie, Yoshihiro Tsuruo, Damon C. Herbert, Akira Naito   +4 more
doaj   +1 more source