Results 71 to 80 of about 17,873 (207)

Does inter-organellar proteostasis impact yeast quality and performance during beer fermentation? [PDF]

, 2019
During beer production, yeast generate ethanol that is exported to the extracellular environment where it accumulates. Depending on the initial carbohydrate concentration in the wort a high concentration of ethanol can be achieved in beer, often higher than 20% (v/v). It is noteworthy that the effects of elevated ethanol concentrations generated during
arxiv   +1 more source

PepMLM: Target Sequence-Conditioned Generation of Therapeutic Peptide Binders via Span Masked Language Modeling [PDF]

arXiv, 2023
Target proteins that lack accessible binding pockets and conformational stability have posed increasing challenges for drug development. Induced proximity strategies, such as PROTACs and molecular glues, have thus gained attention as pharmacological alternatives, but still require small molecule docking at binding pockets for targeted protein ...
arxiv  

Association of the 1q25 diabetes-specific coronary heart disease locus with slterations of the γ-glutamyl cycle and increased methylglyoxal levels in endothelial cells [PDF]

, 2020
A chromosome 1q25 variant (rs10911021) has been associated with coronary heart disease (CHD) in type 2 diabetes. In human umbilical vein endothelial cells (HUVECs), the risk allele "C" is associated with lower expression of the adjacent gene GLUL ...
Alessandro Doria, Assunta Pandolfi, Caterina Pipino, Hetal Shah, Kyoungmin Park, Lixia Zeng, Natalia Di Pietro, Sabrina Prudente, Subramanian Pennathur, Vincenzo Trischitta   +9 more
core   +1 more source

Regulation of plant glycolysis and the tricarboxylic acid cycle by posttranslational modifications

The Plant Journal, Volume 122, Issue 1, April 2025.
SUMMARY Plant glycolysis and the tricarboxylic acid (TCA) cycle are key pathways of central carbon metabolism. They facilitate energy transformation, provide redox balance, and supply the building blocks for biosynthetic processes that underpin plant survival, growth, and productivity.
Ke Zheng, Maria del Pilar Martinez, Maroua Bouzid, Manuel Balparda, Markus Schwarzländer, Veronica G. Maurino   +5 more
wiley   +1 more source

Amino Acids as biomarkers in the SOD1G93A mouse model of ALS [PDF]

, 2014
The development of therapies for Amyotrophic Lateral Sclerosis (ALS) has been hindered by the lack of biomarkers for both identifying early disease and for monitoring the effectiveness of drugs.
Bame, Monica, Brusilow, William S.A., Grier, Robert E., Needleman, Richard   +3 more
core   +1 more source

The Histone Lysine Demethylase KDM7A Contributes to Reward Memory via Fscn1‐Induced Synaptic Plasticity in the Medial Prefrontal Cortex

Advanced Science, Volume 12, Issue 10, March 13, 2025.
This research delineates the role of lysine demethylase 7A (KDM7A) in morphine‐induced reward memory and its effects on gene expression in the medial prefrontal cortex (mPFC). The study identifies fascin actin‐bundling protein 1 (Fscn1) as a downstream target of KDM7A, affecting dendritic spine density and neuronal activity, revealing novel insights ...
Zhuo‐jin Yang, Dong‐yu Yu, Fei‐fei Gao, Dan‐ya Zhou, Ya‐nan Wu, Xi‐xi Yang, Jie Chen, Jing‐si Yang, Meng‐qing Shen, Yu‐xiang Zhang, Lai Wei, Chun‐xia Yan   +11 more
wiley   +1 more source

In silico modeling and evaluation of Gordonia alkanivorans for biodesulfurization [PDF]

, 2013
10.1039/c3mb70132hMolecular BioSystems92530 ...
Aggarwal, Shilpi, Ivan, Gregorius Reinaldi, Karimi, I. A.   +2 more
core   +1 more source

CD147 Mediates the Metabolic Reprogramming of Cancer Associated Fibroblasts Induced by EVs Released by Differentiating Cancer Stem Cells

Journal of Extracellular Biology, Volume 4, Issue 3, March 2025.
ABSTRACT Several reports have demonstrated that CD147, an N‐glycosylated protein that is exchanged by cells in soluble form or through small extracellular vesicles (sEVs), can promote cancer progression. However, its activity related to EVs in colorectal cancer (CRC) is still not fully understood.
Filomena Colella, Federica Calapà, Giulia Artemi, Erica Pazzaglia, Rita Colonna, Sara Vitale, Giacomo Lazzarino, Federica Vincenzoni, Micol Eleonora Fiori, Ruggero De Maria, Sara Lucchisani, Giannicola Genovese, Luigi Perelli, Barbara Tavazzi, Alessandro Sgambato, Donatella Lucchetti   +15 more
wiley   +1 more source

Optimal experimental design in an EGFR signaling and down-regulation model [PDF]

arXiv, 2006
We apply the methods of optimal experimental design to a differential equation model for epidermal growth factor receptor (EGFR) signaling, trafficking, and down-regulation. The model incorporates the role of a recently discovered protein complex made up of the E3 ubiquitin ligase, Cbl, the guanine exchange factor (GEF), Cool-1 (Beta-Pix), and the Rho ...
arxiv  

Identification and in vitro Analysis of the GatD/MurT Enzyme-Complex Catalyzing Lipid II Amidation in Staphylococcus aureus [PDF]

, 2012
The peptidoglycan of Staphylococcus aureus is characterized by a high degree of crosslinking and almost completely lacks free carboxyl groups, due to amidation of the D-glutamic acid in the stem peptide.
A Bera, A Bera, A Bouhss, A Bouhss, A Ornelas-Soares, AM Ludovice, AM Stranden, AM Stranden, Andreas Peschel, B Berger-Bächi, B Pfanzagl, C Yeats, CA Smith, CA Smith, CL White, D Gally, D Patin, Daniela Münch, DJ Scheffers, E Bernard, E Rubinchik, F Massiere, F Zein, G Siewert, H Brötz, H Maidhof, H Zalkin, H Zalkin, Hans Georg Sahl, HH Xu, HJ van Heijenoort, HJ van Heijenoort, HJ van Heijenoort, HJ van Heijenoort, HY van Heijenoort, I Wiedemann, J Gustafson, J Huber, JA Bertrand, JA Thanassi, JE Griffin, JJ Tesmer, JM Krahn, JN Umbreit, JV Höltje, K O'Riordan, KH Schleifer, KK Wong, LA Marraffini, M Jana, M Mir, M Nakel, M Strohmeier, Marianne Engeser, MH Laaberki, RA Forsyth, RG Donald, RR Chaudhuri, S Boyle-Vavra, S Gardete, S Mouilleron, S Mouilleron, S Rohrer, Sang Ho Lee, SD Rubino, SH Lee, SS Hegde, T Bae, T Mohammadi, T Mohammadi, T Schneider, T Schneider, Tanja Schneider, TD Bugg, Terry Roemer, TJ Klem, U Henze, U Kohlrausch   +77 more
core   +5 more sources