Results 111 to 120 of about 41,693 (219)

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure [PDF]

, 2015
Hepatocellular carcinoma (HCC) is characterized by the accumulation of unfolded proteins in the endoplasmic reticulum (ER), which activates the unfolded protein response (UPR).
Ampe, Christophe, Bogaerts, Eliene, Descamps, Benedicte, Devisscher, Lindsey, Geerts, Anja, Govaere, O, Laukens, Debby, Libbrecht, Louis, Paridaens, Annelies, Raevens, Sarah, Van den Bussche, A, Van Steenkiste, Christophe, Van Troys, Marleen, Van Vlierberghe, Hans, Vandewynckel, Yves-Paul, Vanhove, Christian, Verhelst, Xavier   +16 more
core   +3 more sources

Moderate increase of MET in hepatocytes protects against cholestatic liver injury by promoting an effective antioxidant response

The FEBS Journal, EarlyView.
Moderate overexpression of wild‐type Met in hepatocytes (Alb‐R26Met mouse model) boosts a strong antioxidant response dependent on the glutathione system while impairing TGF‐β signaling in the liver. This leads to improved liver regeneration and protects against DDC‐induced injury, a model for cholestatic disease sharing features with primary ...
Carlos González‐Corralejo, Juan García‐Sáez, María Figueroa‐Fuentes, Annalisa Addante, Cesáreo Roncero, Nerea Lazcanoiturburu, Beatriz Pacheco, Julián Sanz, Cristina Gato, Eva Fernández‐Calderón, María de la O López, Águeda González‐Rodríguez, Almudena Porras, Flavio Maina, Isabel Fabregat, Blanca Herrera, Aránzazu Sánchez   +16 more
wiley   +1 more source

Transsulfuration pathway thiols and methylated arginines: the hunter community study [PDF]

, 2013
Background: Serum homocysteine, when studied singly, has been reported to be positively associated both with the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine [ADMA, via inhibition of dimethylarginine dimethylaminohydrolase ...
Attia, John R., Carru, Ciriaco, Mangoni, Arduino A., McEvoy, Mark, Zinellu, Angelo   +4 more
core   +3 more sources

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, EarlyView.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

Expression, purification and characterization of glutamate cysteine ligase from Saccharomyces cerevisiae

The FASEB Journal, 2008
Glutathione is a critical cellular reductant and its homeostasis is required for maintenance of intracellular redox balance. glutamate‐cysteine ligase (GCL) catalyses the ATP‐dependent peptide bond formation between gamma‐carboxylate of glutamate and cysteine, the first step of glutathione biosynthesis.
Ekaterina Biterova, Brandi Sommer, Joseph J Barycki   +2 more
openaire   +1 more source

Discrete and cell‐specific hypoxic responses in Arabidopsis roots resolved by single‐nuclei transcriptomics

New Phytologist, EarlyView.
Summary With the intensification of unpredictable flooding events because of global warming, there is a need to understand how root cells perceive and respond to oxygen deprivation. The use of high‐throughput single‐nuclei RNA‐sequencing (snRNA‐Seq) allows the examination of gene expression profiles in discrete cell types.
Robert D. Hill, Sean M. Robertson, Abir U. Igamberdiev, Mohammed M. Mira, Olivia Wilkins, Claudio Stasolla   +5 more
wiley   +1 more source

Age-dependent regulation of antioxidant genes by p38α MAPK in the liver

Redox Biology, 2018
p38α is a redox sensitive MAPK activated by pro-inflammatory cytokines and environmental, genotoxic and endoplasmic reticulum stresses. The aim of this work was to assess whether p38α controls the antioxidant defense in the liver, and if so, to elucidate
Salvador Pérez, Sergio Rius-Pérez, Ana M. Tormos, Isabela Finamor, Ángel R. Nebreda, Raquel Taléns-Visconti, Juan Sastre   +6 more
doaj   +1 more source

Cleavage of the apoptosis inhibitor DIAP1 by the apical caspase DRONC in both normal and apoptotic drosophila cells [PDF]

, 2005
In Drosophila S2 cells, the apical caspase DRONC undergoes a low level of spontaneous autoprocessing. Unintended apoptosis is prevented by the inhibitor of apoptosis DIAP1, which targets the processed form of DRONC for degradation through its E3 ...
Clem, Rollie J., Means, John C., Muro, Israel   +2 more
core   +1 more source

Decoding plant defense signaling using the defenseless mutant

New Phytologist, EarlyView.
Summary Can plants live without defenses? Mutant analysis in Arabidopsis thaliana has identified numerous regulators of biotic, abiotic, and hormone‐based defenses, but the redundancy among separate defense pathways remains unexplored. We constructed an Arabidopsis mutant, defenseless, lacking six canonical defense pathways using abi1‐1 (abscisic acid),
Bikash Baral, Mikael Brosché
wiley   +1 more source

Implication of the glutamate-cystine antiporter xCT in schizophrenia cases linked to impaired GSH synthesis. [PDF]

, 2017
xCT is the specific chain of the cystine/glutamate antiporter, which is widely reported to support anti-oxidant defenses in vivo. xCT is therefore at the crossroads between two processes that are involved in schizophrenia: oxidative stress and ...
Baumann, P.S., Conus, P., Do, K., Ferrari, C., Fournier, M., Monin, A.   +5 more
core   +3 more sources