Parallel Strategy Increases the Thermostability and Activity of Glutamate Decarboxylase [PDF]
Molecules, 2020 Glutamate decarboxylase (GAD; EC 4.1.1.15) is a unique pyridoxal 5-phosphate (PLP)-dependent enzyme that specifically catalyzes the decarboxylation of L-glutamic acid to produce γ-aminobutyric acid (GABA), which exhibits several well-known ...
Qing-Fei Zhang +5 more
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Exploring the contributions of two glutamate decarboxylase isozymes in Lactobacillus brevis to acid resistance and γ-aminobutyric acid production. [PDF]
Microb Cell Fact, 2018 BackgroundThe glutamate decarboxylase (GAD) system of Lactobacillus brevis involves two isoforms of GAD, GadA and GadB, which catalyze the conversion of L-glutamate to γ-aminobutyric acid (GABA) in a proton-consuming reaction contributing to ...
Lyu C +8 more
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Expanding the pH range of glutamate decarboxylase from L. pltarum LC84 by site-directed mutagenesis [PDF]
Frontiers in Bioengineering and Biotechnology, 2023 Introduction: Glutamate decarboxylase is a class Ⅱ amino acid decarboxylase dependent onpyridoxal-5′-phosphate (PLP), which catalyzes the decarboxylation of substrateL-glutamate (L-Glu) to synthesize γ-aminobutyric acid (GABA).
Lijuan Yang +6 more
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Glutamate Decarboxylase from Lactic Acid Bacteria-A Key Enzyme in GABA Synthesis. [PDF]
Microorganisms, 2020 Glutamate decarboxylase (l-glutamate-1-carboxylase, GAD; EC 4.1.1.15) is a pyridoxal-5’-phosphate-dependent enzyme that catalyzes the irreversible α-decarboxylation of l-glutamic acid to γ-aminobutyric acid (GABA) and CO2.
Yogeswara IBA, Maneerat S, Haltrich D.
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Frontiers in Behavioral Neuroscience, 2015 Autoantibodies to the smaller isoform of glutamate decarboxylase can be found in patients with type 1 diabetes and a number of neurological disorders, including stiff-person syndrome, cerebellar ataxia and limbic encephalitis.
Mario U Manto +10 more
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Divergent evolution of the activity and regulation of the glutamate decarboxylase systems in Listeria monocytogenes EGD-e and 10403S: roles in virulence and acid tolerance. [PDF]
PLoS ONE, 2014 The glutamate decarboxylase (GAD) system has been shown to be important for the survival of Listeria monocytogenes in low pH environments. The bacterium can use this faculty to maintain pH homeostasis under acidic conditions.
Conor Feehily +6 more
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Global knockdown of glutamate decarboxylase 67 elicits emotional abnormality in mice [PDF]
Molecular Brain, 2021 Reduced expression of glutamate decarboxylase 67 (GAD67), encoded by the Gad1 gene, is a consistent finding in postmortem brains of patients with several psychiatric disorders, including schizophrenia, bipolar disorder and major depressive disorder.
Shigeo Miyata +12 more
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Three Distinct Glutamate Decarboxylase Genes in Vertebrates. [PDF]
Sci Rep, 2016 Gamma-aminobutyric acid (GABA) is a widely conserved signaling molecule that in animals has been adapted as a neurotransmitter. GABA is synthesized from the amino acid glutamate by the action of glutamate decarboxylases (GADs). Two vertebrate genes, GAD1
Grone BP, Maruska KP.
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Pyridoxine Supplementation Improves the Activity of Recombinant Glutamate Decarboxylase and the Enzymatic Production of Gama-Aminobutyric Acid. [PDF]
PLoS ONE, 2016 Glutamate decarboxylase (GAD) catalyzes the irreversible decarboxylation of L-glutamate to the valuable food supplement γ-aminobutyric acid (GABA).
Yan Huang, Lingqia Su, Jing Wu
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Cell DiscoveryKetogenic diet (KD) alleviates refractory epilepsy and reduces seizures in children. However, the metabolic/cell biologic mechanisms by which the KD exerts its antiepileptic efficacy remain elusive.
Ya-Nan Qiao +14 more
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