Results 41 to 50 of about 227,873 (271)
Response of tyramine and glutamate related signals to nanoplastic exposure in Caenorhabditis elegans
Ecotoxicology and Environmental Safety, 2021 Neurotransmission related signals are involved in the control of response to toxicants. We here focused on the tyramine and the glutamate related signals to determine their roles in regulating nanoplastic toxicity in Caenorhabditis elegans.
Shuting Wang +3 more
doaj +1 more source
Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan +22 more
wiley +1 more source
Advanced Science, EarlyView.Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan +9 more
wiley +1 more source
Bmal1 knockdown suppresses wake and increases immobility without altering orexin A, corticotrophin-releasing hormone, or glutamate decarboxylase. [PDF]
CNS Neurosci Ther, 2018 Akladious A, Azzam S, Hu Y, Feng P.
europepmc +3 more sources
Advanced Science, EarlyView.This study reports early Piezo1 activation in bone marrow monocyte‐derived macrophages (MoMs) during myocardial infarction (MI), which governs the fate and function of recruited macrophages. The recruited MoMs with increased Piezo1 expression exhibit increased ferroptosis and defective efferocytosis, delayed clearance of dead cells and resolution of ...
Lu Peng +19 more
wiley +1 more source
Is there a correlation between GAD2 gene-243 A>G polymorphism and obesity?
Romanian Journal of Laboratory Medicine, 2019 Introduction: GAD2 gene encodes the glutamate decarboxylase enzyme which catalyses the transformation of glutamate into γ-aminobutyric acid, GABA.
Alkhzouz Camelia +5 more
doaj +1 more source
Metabolic engineering of Escherichia coli for the biosynthesis of 2-pyrrolidone
Metabolic Engineering Communications, 2016 2-Pyrrolidone is a valuable bulk chemical with myriad applications as a solvent, polymer precursor and active pharmaceutical intermediate. A novel 2-pyrrolidone synthase, ORF27, from Streptomyces aizunensis was identified to catalyze the ring closing ...
Jingwei Zhang +5 more
doaj +1 more source
Microbial Biotechnology, 2015 Gamma‐aminobutyric acid (GABA) is an important bioactive compound biosynthesized by microorganisms through decarboxylation of glutamate by glutamate decarboxylase (GAD).
N. Tajabadi +7 more
semanticscholar +1 more source
Advanced Science, EarlyView.An electrochemical system is designed to convert CO2 into CO2‐derived electrolytes (CDE), mainly containing acetate and formate. The underlying mechanism of acetate metabolism in Halomonas TD80 is explored via ALE. Engineered TD80 produced high‐yield diversified products from CDE.
Chi Wang +18 more
wiley +1 more source
Аутизм и нарушение развития, 2020 Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by reduced social communication and repetitive behaviors.
A. El-Ansary
doaj +1 more source