S-Sulfocysteine's toxic effects on HT-22 cells are not triggered by glutamate receptors, nor do they involve apoptotic or genotoxicity mechanisms. [PDF]
Tekin V +6 more
europepmc +1 more source
Whole Nervous System Expression of Glutamate Receptors Reveals Distinct Receptor Roles in Sensorimotor Circuits. [PDF]
Borba C +5 more
europepmc +1 more source
Signaling Specificity and Kinetics of the Human Metabotropic Glutamate Receptors. [PDF]
McCullock TW +2 more
europepmc +1 more source
A 'double-edged' role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs. [PDF]
Notartomaso S +17 more
europepmc +1 more source
Nanoscale Reorganization of Glutamate Receptors Underlies Synaptic Plasticity and Pathology. [PDF]
Chen JH, Tang AH.
europepmc +1 more source
"Niclosamide: A potential antipruritic agent by modulating serotonin pathway through metabotropic glutamate receptors (mGluRs)". [PDF]
Ebrahim Soltani Z +4 more
europepmc +1 more source
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The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
Michael Hollmann, Stephen Heinemann
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Pain is an important survival and protection mechanism for animals. However, chronic/persistent pain may be differentiated from normal physiological pain in that it confers no obvious advantage. An accumulating body of pharmacological, electrophysiological, and behavioral evidence is emerging in support of the notion that glutamate receptors play a ...
David, Bleakman +2 more
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Structure of Glutamate Receptors
Current Drug Targets, 2007Glutamate receptors mediate a vast array of processes in plants, animals and bacteria. In particular, the ionotropic glutamate receptors (iGluRs) are the most abundant excitatory neurotransmitter receptors in the mammalian central nervous system. Because these proteins are constructed from distinct folding domains, most of which can be traced to ...
Robert E, Oswald +3 more
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Metabotropic glutamate receptors
Cell and Tissue Research, 2006Metabotropic glutamate receptors (mGlus) are a family of G-protein-coupled receptors activated by the neurotransmitter glutamate. Molecular cloning has revealed eight different subtypes (mGlu1-8) with distinct molecular and pharmacological properties. Multiplicity in this receptor family is further generated through alternative splicing. mGlus activate
Ferraguti F., Shigemoto R.
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