Results 11 to 20 of about 69,631 (334)

Metabotropic Glutamate Receptors Inhibit Microglial Glutamate Release [PDF]

ASN Neuro, 2012
Pro-inflammatory stimuli evoke an export of glutamate from microglia that is sufficient to contribute to excitotoxicity in neighbouring neurons. Since microglia also express various glutamate receptors themselves, we were interested in the potential feedback of glutamate on this system. Several agonists of mGluRs (metabotropic glutamate receptors) were
Stephen M McMullan, Bounleut Phanavanh, Gary Guo Li, Steven W Barger   +3 more
openaire   +3 more sources

Glutamate, Glutamate Receptors, and Downstream Signaling Pathways [PDF]

International Journal of Biological Sciences, 2013
Glutamate is a nonessential amino acid, a major bioenergetic substrate for proliferating normal and neoplastic cells, and an excitatory neurotransmitter that is actively involved in biosynthetic, bioenergetic, metabolic, and oncogenic signaling pathways. Glutamate signaling activates a family of receptors consisting of metabotropic glutamate receptors (
Willard, Stacey S., Koochekpour, Shahriar   +1 more
openaire   +2 more sources

Synthesis and viscosity behavior of poly(γ-p-biphenylmethyl-L-glutamate) in benzene/dichloroacetic acid mixtures, a comparison with poly(γ-benzyl-L-glutamate) [PDF]

, 1974
The synthesis of poly(γ-p-biphenylmethyl-L-glutamate), PBPLG, (poly{L-imino-1-[2-(4-biphenylylmethoxycarbonyl)ethyl]-2-oxoethylene}), (1d) is described. The viscosity behavior of this polymer in benzene/dichloroacetic acid mixtures (c=0,2.10 -3 - 1,4.10 -
Bantjes, Adriaan, Feijen, Jan, Groot, Klaas de, Sederel, Wim L., Visser, Anthonie C. de   +4 more
core   +3 more sources

Ancestral roles of the Fam20C family of secreted protein kinases revealed in C. elegans. [PDF]

, 2019
Fam20C is a secreted protein kinase mutated in Raine syndrome, a human skeletal disorder. In vertebrates, bone and enamel proteins are major Fam20C substrates.
Adina Gerson-Gurwitz, Arribere, Arshad Desai, Bahl, Bando, Bies, Brown, Byerly, Cancino, Carolyn A. Worby, Carrascal, Cui, Dhanya Cheerambathur, Erin J. Cram, Fradin, Frøkjaer-Jensen, Gerald, Ghazarian, Gibson, Gorelik, Green, Ishikawa, Jack E. Dixon, Jeff Bouffard, Johnson, Kamath, Karen Oegema, Kian-Yong Lee, Kim, Kimble, Koike, Koob, Kovacevic, Köppen, Leiser, Leiser, Levin, Lindberg, Mann, Manning, Minko, Mody, Nakamura, Paschinger, Petrella, Pollak, Pollard, Pulvirenti, Raine, Reinhart, Renat Khaliullin, Rolls, Salvi, Sievers, Simpson, Sreelatha, Tagliabracci, Tagliabracci, Tagliabracci, Takeuchi, Tseng, Vogel, Wang, Ward, Wen, Wewer, Xiao, Yue, Zhang, Zhou, Zhou   +70 more
core   +3 more sources

Effects of Antipsychotic Administration on Brain Glutamate in Schizophrenia: A Systematic Review of Longitudinal 1H-MRS Studies

Frontiers in Psychiatry, 2017
Schizophrenia is associated with brain glutamate dysfunction, but it is currently unclear whether antipsychotic administration can reduce the extent of glutamatergic abnormality. We conducted a systematic review of proton magnetic resonance spectroscopy (
Alice Egerton, Akarmi Bhachu, Kate Merritt, Grant McQueen, Agata Szulc, Philip McGuire   +5 more
doaj   +1 more source

Synthesis and photochemical reactivity of caged glutamates with a π-​extended coumarin chromophore as a photolabile protecting group [PDF]

, 2013
International audience'Caging' and 'uncaging' bioactive substrates are key techniques in studying a wide variety of biological processes. In the present study, two-types of novel caged glutamates with a two-photon absorption (TPA) core, that is, π ...
Abe, Manabu, Boinapally, Srikanth, Katan, Claudine, Sakamoto, Yuya   +3 more
core   +2 more sources

Emerging trends in pharmacological strategies for targeting neuroinflammation in depression [PDF]

Scripta Medica
The article discusses evolving pharmacological strategies for addressing the neuroinflammation in depression, highlighting its role in major depressive disorder.
Kumari Anshu, Sharma Rahul Kumar, Chopra Shivani, Chopra Hitesh   +3 more
doaj   +1 more source

Acidic amino acids in the first intracellular loop contribute to voltage- and calcium- dependent gating of anoctamin1/TMEM16A. [PDF]

PLoS ONE, 2014
Anoctamin1 (Ano1, or TMEM16A) is a Ca2+-activated chloride channel that is gated by both voltage and Ca2+. We have previously identified that the first intracellular loop that contains a high density of acidic residues mediates voltage- and calcium ...
Qinghuan Xiao, Yuanyuan Cui
doaj   +1 more source

Structural insights into the electron/proton transfer pathways in the quinol:fumarate reductase from Desulfovibrio gigas [PDF]

, 2018
The membrane-embedded quinol:fumarate reductase (QFR) in anaerobic bacteria catalyzes the reduction of fumarate to succinate by quinol in the anaerobic respiratory chain. The electron/proton-transfer pathways in QFRs remain controversial.
Chan, Sunney I., Chen, Chun-Jung, Chen, Li-Ying, Chen, Nai-Chi, Chen, Shao-Kang, Chuankhayan, Phimonphan, Guan, Hong-Hsiang, Hsieh, Yin-Cheng, Huang, Yen-Chieh, Lin, Chien-Chih, Lin, Pei-Ju, Nakagawa, Atsushi, Yoshimura, Masato   +12 more
core   +2 more sources

Vicinal glutamates are better phosphomimetics: Phosphorylation is required for allosteric activation of guanylyl cyclase-A

Frontiers in Molecular Neuroscience, 2022
Multisite phosphorylation of guanylyl cyclase (GC)-A, also known as NPR-A or NPR1, is required for receptor activation by natriuretic peptides (NPs) because alanine substitutions for the first four GC-A phosphorylation sites produce an enzyme that cannot
Neil M. Otto, Lincoln R. Potter
doaj   +1 more source