Results 21 to 30 of about 64,174 (206)

Epitope-tagged and phosphomimetic mouse models for investigating natriuretic peptide-stimulated receptor guanylyl cyclases

open access: yesFrontiers in Molecular Neuroscience, 2022
The natriuretic peptide receptors NPR1 and NPR2, also known as guanylyl cyclase A and guanylyl cyclase B, have critical functions in many signaling pathways, but much remains unknown about their localization and function in vivo. To facilitate studies of
Jeremy R. Egbert   +13 more
doaj   +1 more source

Pharmacotherapy of Schizophrenia: Ploypharmacy Approaches [PDF]

open access: yesActa Medica Iranica, 2010
"nSchizophrenia is a debilitating illness, rating as one of the leading causes of lost years of quality of life. The illness imposes a disproportionate burden on patients and their families, healthcare systems and society. Pharmacological management
Fatemeh Rahiminejad, Shahin Akhondzadeh
doaj   +2 more sources

Obesity as a Limiting Factor for Remote Ischemic Postconditioning-Mediated Neuroprotection after Stroke

open access: yesJournal of Obesity & Metabolic Syndrome
Background : Remote ischemic postconditioning (RIPostC) may protect the brain from ischemia/reperfusion (I/R) injury. The association between RIPostC and obesity has not yet been extensively studied.
Klaudia Kotorová   +4 more
doaj   +1 more source

Beyond Sulfate-Free Personal Cleansing Technology

open access: yesCosmetics
There is a strong global demand for sulfate-free personal cleansing products. The objective of sulfate-free personal cleansing technology should not be aimed solely at the absence of “sulfate” wording in the list of ingredients, but on the true benefits ...
Evelyn Su, Stephen Herman
doaj   +1 more source

Expression and purification of recombinant vesicular glutamate transporter VGLUT1 using PC12 cells and High Five insect cells

open access: yesBiological Procedures Online, 2004
In synaptic vesicles, the estimated concentration of the excitatory amino acid glutamate is 100-150 mM. It was recently discovered that VGLUT1, previously characterized as an inorganic phosphate transporter (BNPI) with 9-11 predicted transmembrane ...
Andersen Søren S.L.
doaj   +1 more source

Energy metabolism and glutamate-glutamine cycle in the brain: a stoichiometric modeling perspective [PDF]

open access: yesBMC Systems Biology 7:103 (2013), 2013
The energetics of cerebral activity critically relies on the functional and metabolic interactions between neurons and astrocytes. Important open questions include the relation between neuronal versus astrocytic energy demand, glucose uptake and intercellular lactate transfer, as well as their dependence on the level of activity.
arxiv   +1 more source

Long-term NMDAR antagonism correlates reduced astrocytic glutamate uptake with anxiety-like phenotype

open access: yesFrontiers in Cellular Neuroscience, 2015
The role of glutamate N-methyl-D-Aspartate receptor (NMDAR) hypofunction has been extensively studied in schizophrenia; however, less is known about its role in anxiety disorders.
Eduardo R Zimmer   +12 more
doaj   +1 more source

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

open access: yesFEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

open access: yesFEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga   +6 more
wiley   +1 more source

Cofactor Tail Length Modulates Catalysis of Bacterial F420-Dependent Oxidoreductases

open access: yesFrontiers in Microbiology, 2017
F420 is a microbial cofactor that mediates a wide range of physiologically important and industrially relevant redox reactions, including in methanogenesis and tetracycline biosynthesis.
Blair Ney   +11 more
doaj   +1 more source

Home - About - Disclaimer - Privacy