Results 21 to 30 of about 226,163 (382)
Frontiers in Psychiatry, 2017 Schizophrenia is associated with brain glutamate dysfunction, but it is currently unclear whether antipsychotic administration can reduce the extent of glutamatergic abnormality. We conducted a systematic review of proton magnetic resonance spectroscopy (
Alice Egerton +5 more
doaj +1 more source
Synthesis and photochemical reactivity of caged glutamates with a π-extended coumarin chromophore as a photolabile protecting group [PDF]
, 2013 International audience'Caging' and 'uncaging' bioactive substrates are key techniques in studying a wide variety of biological processes. In the present study, two-types of novel caged glutamates with a two-photon absorption (TPA) core, that is, π ...
Abe, Manabu +3 more
core +2 more sources
Acidic amino acids in the first intracellular loop contribute to voltage- and calcium- dependent gating of anoctamin1/TMEM16A. [PDF]
PLoS ONE, 2014 Anoctamin1 (Ano1, or TMEM16A) is a Ca2+-activated chloride channel that is gated by both voltage and Ca2+. We have previously identified that the first intracellular loop that contains a high density of acidic residues mediates voltage- and calcium ...
Qinghuan Xiao, Yuanyuan Cui
doaj +1 more source
Cytosolic Carboxypeptidase 5 Removes α- and γ-Linked Glutamates from Tubulin*
Journal of Biological Chemistry, 2013 Background: Cytosolic carboxypeptidase 5 (CCP5) was proposed to selectively cleave γ-linked glutamate from tubulin side chains, but not α-linked glutamates. Results: Purified CCP5 removes α- and γ-linked glutamates from microtubules, soluble tubulin, and
Iryna Berezniuk +7 more
semanticscholar +1 more source
Structural insights into the electron/proton transfer pathways in the quinol:fumarate reductase from Desulfovibrio gigas [PDF]
, 2018 The membrane-embedded quinol:fumarate reductase (QFR) in anaerobic bacteria catalyzes the reduction of fumarate to succinate by quinol in the anaerobic respiratory chain. The electron/proton-transfer pathways in QFRs remain controversial.
Chan, Sunney I. +12 more
core +2 more sources
The unanticipated complexity of the selectivity-filter glutamates of nicotinic receptors
Nature Chemical Biology, 2012 In ion channels, “rings” of ionized side chains that decorate the walls of the permeation pathway often lower the energetic barrier to ion conduction.
G. Cymes, C. Grosman
semanticscholar +1 more source
Frontiers in Molecular Neuroscience, 2022 Multisite phosphorylation of guanylyl cyclase (GC)-A, also known as NPR-A or NPR1, is required for receptor activation by natriuretic peptides (NPs) because alanine substitutions for the first four GC-A phosphorylation sites produce an enzyme that cannot
Neil M. Otto, Lincoln R. Potter
doaj +1 more source
Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin. [PDF]
, 2017 Gene silencing by heterochromatin is proposed to occur in part as a result of the ability of heterochromatin protein 1 (HP1) proteins to spread across large regions of the genome, compact the underlying chromatin and recruit diverse ligands.
Agard, David A +8 more
core +1 more source
The Journal of Nutrition, 2000 Epileptic syndromes have very diverse primary causes, which may be genetic, developmental or acquired. In rodent models, altering glutamate receptor or glutamate transporter expression by knockout or knockdown procedures can induce or suppress epileptic seizures.
openaire +3 more sources
A structural and functional model for human bone sialoprotein [PDF]
, 2012 Human bone sialoprotein (BSP) is an essential component of the extracellular matrix of bone. It is thought to be the primary nucleator of hydroxyapatite crystallization, and is known to bind to hydroxyapatite, collagen, and cells.
Durrant, Marcus, Vincent, Kevin
core +1 more source