Results 61 to 70 of about 226,163 (382)

Metabotropic Glutamate Receptors Inhibit Microglial Glutamate Release [PDF]

ASN Neuro, 2012
Pro-inflammatory stimuli evoke an export of glutamate from microglia that is sufficient to contribute to excitotoxicity in neighbouring neurons. Since microglia also express various glutamate receptors themselves, we were interested in the potential feedback of glutamate on this system. Several agonists of mGluRs (metabotropic glutamate receptors) were
Steven W. Barger, Stephen M McMullan, Bounleut Phanavanh, Gary Guo Li   +3 more
openaire   +4 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Protein kinase C (PKC) phosphorylates the system N glutamine transporter SN1 (slc38a3) and regulates its membrane trafficking and degradation

Frontiers in Endocrinology, 2013
The system N transporter SN1 (also known as SNAT3) is enriched on perisynaptic astroglial cell membranes. SN1 mediates electroneutral and bidirectional glutamine transport, and regulates the intracellular as well as the extracellular concentrations of ...
Lise Sofie H. Nissen-Meyer, Farrukh Abbas Chaudhry   +1 more
doaj   +1 more source

Quantitative peptidomics of Purkinje cell degeneration mice. [PDF]

PLoS ONE, 2013
Cytosolic carboxypeptidase 1 (CCP1) is a metallopeptidase that removes C-terminal and side-chain glutamates from tubulin. The Purkinje cell degeneration (pcd) mouse lacks CCP1 due to a mutation.
Iryna Berezniuk, Juan J Sironi, Jonathan Wardman, Raymond C Pasek, Nicolas F Berbari, Bradley K Yoder, Lloyd D Fricker   +6 more
doaj   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Zn(OAc)2-Catalyzing Ring-Opening Polymerization of N-Carboxyanhydrides for the Synthesis of Well-Defined Polypeptides

Molecules, 2018
Despite notable progress, the fabrication of well-defined polypeptides via controlled ring-opening polymerization (ROP) of α-amino acid N-carboxyanhydrides (NCAs) using convenient catalysts under mild conditions in a relatively short polymerization time ...
Yanzhao Nie, Xinmei Zhi, Haifeng Du, Jing Yang   +3 more
doaj   +1 more source

Conformational Dynamics and Thermal Cones of C-terminal Tubulin Tails in Neuronal Microtubules [PDF]

, 2007
In this paper we present a model for estimation of the C-terminal tubulin tail (CTT) dynamics in cytoskeletal microtubules of nerve cells. We show that the screened Coulomb interaction between a target CTT and the negatively charged microtubule surface ...
Georgiev, Danko, Glazebrook, James
core   +1 more source

Glutamate-induced Exocytosis of Glutamate from Astrocytes

Journal of Biological Chemistry, 2007
Recent studies indicate that astrocytes can play a much more active role in neuronal circuits than previously believed, by releasing neurotransmitters such as glutamate and ATP. Here we report that local application of glutamate or glutamine synthetase inhibitors induces astrocytic release of glutamate, which activates a slowly decaying transient ...
Jane H.-C. Lin, Ning Kang, Zhuo Zhao, Hong Peng, Patric K. Stanton, Jian Kang, Jun Xu   +6 more
openaire   +3 more sources

Life without glutamate: the epigenetic effects of glutamate deletion [PDF]

Frontiers in Molecular Neuroscience, 2014
Li et al. (2013) studied ThVGdKO mice produced by genetic elimination of the genes for both vesicular transporters Vglut-1 and Vglut-2. In these mice thalamocortical glutamate neurotransmission in somatosensory cortex (but not in visual or auditory cortex) is silenced or knocked-out, thereby disabling the release of glutamate from synaptic vesicles ...
John Smythies, Kjell Fuxe, Lawrence Edelstein   +2 more
openaire   +4 more sources

CD9‐association with PIP2 areas is regulated by a CD9 salt bridge

FEBS Open Bio, EarlyView.
The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi, Sara C. Konopka, Thorsten Lang   +2 more
wiley   +1 more source