Results 61 to 70 of about 155,970 (214)

Poly-γ-glutamylation of biomolecules

Nature Communications
Poly-γ-glutamate tails are a distinctive feature of archaeal, bacterial, and eukaryotic cofactors, including the folates and F420. Despite decades of research, key mechanistic questions remain as to how enzymes successively add glutamates to poly-γ ...
Ghader Bashiri, Esther M. M. Bulloch, William R. Bramley, Madison Davidson, Stephanie M. Stuteley, Paul G. Young, Paul W. R. Harris, Muhammad S. H. Naqvi, Martin J. Middleditch, Michael Schmitz, Wei-Chen Chang, Edward N. Baker, Christopher J. Squire   +12 more
doaj   +1 more source

Biological Sources of Inflexibility in Brain and Behavior with Aging and Neurodegenerative Diseases

Frontiers in Systems Neuroscience, 2012
Almost unequivocally, aging and neurodegeneration lead to deficits in neural information processing. These declines are marked by increased neural noise that is associated with increased variability or inconsistency in behavioral patterns.
S. Lee eHong, George V. Rebec
doaj   +1 more source

Targeting glutamate metabolism in melanoma [PDF]

arXiv, 2019
The glutamate metabotropic receptor 1 (GRM1) drives oncogenesis when aberrantly activated in melanoma and several other cancers. Metabolomics reveals that patient-derived xenografts with GRM1-positive melanoma tumors exhibit elevated plasma glutamate levels associated with metastatic melanoma in vivo. Stable isotope tracing and GCMS analysis determined
arxiv  

Surface grafting of poly (L-glutamates). 1. Synthesis and characterization

, 2001
The ring-opening polymerization of N-carboxyanhydrides (NCA) of γ-benzyl l-glutamate and γ-methyl l-glutamate from (γ-aminopropyl)triethoxysilane (APS) pretreated substrates such as silicon wafers and quartz slides was investigated.
R. H. Wieringa, E. Siesling, P. Geurts, P. Werkman, E. Vorenkamp, V. Erb, M. Stamm, A. Schouten   +7 more
semanticscholar   +1 more source

Regulation of folylpoly-gamma-glutamate synthesis in bacteria: in vivo and in vitro synthesis of pteroylpoly-gamma-glutamates by Lactobacillus casei and Streptococcus faecalis

Journal of Bacteriology, 1983
Lactobacillus casei and Streptococcus faecalis accumulated labeled folic acid and metabolized this compound to poly-gamma-glutamates of chain lengths of up to 11 and 5, respectively. Octa- and nonaglutamates predominated in L.
B. Shane, A. Bognar, R. Goldfarb, J. Lebowitz   +3 more
semanticscholar   +1 more source

Evidence of blood–brain barrier dysfunction and CSF immunoglobulin synthesis in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives This study sought to evaluate proteomic, metabolomic, and immune signatures in the cerebrospinal fluid of individuals with Down Syndrome Regression Disorder (DSRD). Methods A prospective case–control study comparing proteomic, metabolomic, and immune profiles in individuals with DSRD was performed.
Jonathan D. Santoro, Neetha Paul Eduthan, Mellad M. Khoshnood, Saba Jafarpour, Natalie K. Boyd, Benjamin N. Vogel, Lina Nguyen, Lilia Kazerooni, Eleanor Britton, Hannah R. Lyford, Matthew D. Galbraith, Angela L. Rachubinski, Joaquin M. Espinosa   +12 more
wiley   +1 more source

A computational study on synaptic and extrasynaptic effects of astrocyte glutamate uptake on orientation tuning in V1 [PDF]

arXiv, 2017
Astrocytes affect neural transmission by a tight control via glutamate transporters on glutamate concentrations in direct vicinity to the synaptic cleft and by extracellular glutamate. Their relevance for information representation has been supported by in-vivo studies in ferret and mouse primary visual cortex.
arxiv  

Regulating Protein Immobilization During Cell‐Free Protein Synthesis in Hyaluronan Microgels

Advanced Biology, EarlyView.
Bifunctional microgels carrying a linear DNA template and Ni2+‐activated NTA moieties are used as platform for cell‐free protein synthesis and in situ protein immobilization. By varying the concentration of NTA moieties in the microgels, the amount of GFP‐His immobilized inside the microgel and released to the microgel environment can be regulated ...
Anika Kaufmann, Kateryna Ivanova, Julian Thiele   +2 more
wiley   +1 more source

Estimating the synaptic current in a multi-conductance AMPA receptor model [PDF]

, 2010
A pre-synaptic neuron releases diffusing neurotransmitters such as glutamate that activate post-synaptic receptors. The amplitude of the post-synaptic current, mostly mediated by glutamatergic (AMPARs) receptors, is a fundamental signal that may generate an action potential.
arxiv   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source