Results 81 to 90 of about 155,970 (214)

Magnetic resonance imaging in studying schizophrenia, negative symptoms and the glutamate system

Frontiers in Psychiatry, 2014
Schizophrenia is characterized by positive, negative and cognitive symptoms. While positive symptoms occur periodically during psychotic exacerbations, negative and cognitive symptoms often emerge before the first psychotic episode and persist with low ...
Oliver eGruber, Antonella eSantuccione Chadha, Helmut eAach   +2 more
doaj   +1 more source

Biomimetic Co‐delivery of Lenvatinib and FePt Nanoparticles for Enhanced Ferroptosis/Apoptosis Treatment of Hepatocellular Carcinoma

Advanced Healthcare Materials, EarlyView.
This study introduces a novel HCC treatment using poly lactic‐co‐glycolic acid (PLGA) nanoparticles encased in HCC cell membranes to co‐deliver Lenvatinib and FePt nanoparticles. This approach improves treatment efficacy by enhancing ferroptosis and apoptosis.
Feichao Xuan, Xingyang Zhao, Weiran Pang, Zirong Li, Xiangyi Yin, Weizhong Xie, Xiaojun Zeng, Liming Nie, Junying Yang, Shiying Li, Puxiang Lai, Chihua Fang   +11 more
wiley   +1 more source

What does the mediodorsal thalamus do?

Frontiers in Systems Neuroscience, 2013
Dense amnesia can result from damage to the medial diencephalon in humans and in animals. In humans this damage is diffuse and can include the mediodorsal nuclei of the thalamus.
Anna S Mitchell, Subhojit eChakraborty
doaj   +1 more source

Crystal Structure of the Calcium Release–Activated Calcium Channel Orai

Science, 2012
Architecture of a CRAC The calcium release–activated calcium (CRAC) channel generates intracellular calcium signals in response to depletion of calcium from the endoplasmic reticulum. Hou et al. (p.
X. Hou, L. Pedi, M. Diver, S. Long
semanticscholar   +1 more source

A Wireless Cortical Surface Implant for Diagnosing and Alleviating Parkinson's Disease Symptoms in Freely Moving Animals

Advanced Healthcare Materials, EarlyView.
A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin, Kyungtae Kim, Jaeseung Lee, Johyeon Nam, Eunha Baeg, Chaeyeon You, Hanseul Choi, Minji Kim, Chun Kee Chung, Jae Geun Kim, Jong Hyun Ahn, Miryung Han, Jibum Kim, Sungchil Yang, Sung Q Lee, Sunggu Yang   +15 more
wiley   +1 more source

Computational models of astrocyte function at glutamatergic synapses [PDF]

New Technologies for Glutamate Interactions: Neurons and Glia, edited by Maria Kukley, 2024, Springer Protocols
At tripartite synapses, astrocytes are in close contact with neurons and contribute to various functions, from synaptic transmission, maintenance of ion homeostasis and glutamate uptake to metabolism. However, disentangling the precise contribution of astrocytes to those phenomena and the underlying biochemical mechanisms is remarkably challenging ...
arxiv   +1 more source

Surface Grafting of Poly(l-glutamates). 3. Block Copolymerization

, 2001
This paper describes for the first time the synthesis of surface-grafted AB-block copolypeptides, consisting of poly(γ-benzyl l-glutamate) (PBLG) as the A-block and poly(γ-methyl l-glutamate) (PMLG...
R. H. Wieringa, E. Siesling, P. Werkman, E. Vorenkamp, A. Schouten   +4 more
semanticscholar   +1 more source

Development of Itaconate Polymers Microparticles for Intracellular Regulation of Pro‐Inflammatory Macrophage Activation

Advanced Healthcare Materials, EarlyView.
This study develops itaconate‐based polymer microparticles (IA‐MPs) for macrophage‐targeted intracellular delivery, overcoming the limitations of traditional itaconate administration. IA‐MPs achieve controlled release through phagocytosis, reducing pro‐inflammatory cytokine expression and reprogramming macrophage metabolism toward glycolysis.
Kaitlyn E. Woodworth, Zachary S.C.S. Froom, Natasha D. Osborne, Christian N. Rempe, Brenden Wheeler, Kyle Medd, Neal I. Callaghan, Huikang Qian, Abhinav P. Acharya, Carlie Charron, Locke Davenport Huyer   +10 more
wiley   +1 more source

Covalent Organic Frameworks for Photocatalysis

Advanced Materials, EarlyView.
This review provides an overview of recent advances in covalent organic frameworks (COFs) for photocatalysis, focusing on sustainable energy applications like water splitting, hydrogen peroxide generation, and CO2 and N2 reduction. It discusses design principles, structure‐function relationships, challenges in COF photocatalysis, and strategies to ...
Bikash Mishra, Akhtar Alam, Avanti Chakraborty, Bidhan Kumbhakar, Samrat Ghosh, Pradip Pachfule, Arne Thomas   +6 more
wiley   +1 more source

Alterations in the chain length of pteroylpoly-gamma-glutamates and in the activity of pteroylpoly-gamma-glutamate hydrolase in response to changes in the steady state of one carbon metabolism.

American Journal of Clinical Nutrition, 1977
The effect of a high protein diet and of limiting dietary methionine and choline on the relative proportions of the various pteroylpoly-y-glutamates, conjugase activity, and folate content in liver of male Japanese quail was determined.
R. Thompson, J. Leichter, P. Cornwell, C. Krumdieck   +3 more
semanticscholar   +1 more source