Results 41 to 50 of about 42,820 (244)

Ontogeny of synaptophysin and synaptoporin in the central nervous system [PDF]

, 1993
The expression of the synaptic vesicle antigens synaptophysin (SY) and synaptoporin (SO) was studied in the rat striatum, which contains a nearly homogeneous population of GABAergic neurons. In situ hybridization revealed high levels of SY transcripts in
B. Marquèze-Pouey, Bergmann, Betz, D. Grabs, Goldman-Rakic, Graybiel, H. Betz, Heimer, Hsu, I. Reisert, Iñiguez, Jahn, Jahn, Kita, Knaus, Lahr, Lauder, Leube, Lindefors, M. Bergmann, M. Gratzl, Marquèze-Pouey, Mugnaini, Newman-Gage, Olson, P. Knaus, Reiner, Reisert, Smith, Specht, Specht, Südhof, Thomas, Vernier, W. Ovtscharoff, Wiedenmann, Wilson   +36 more
core   +1 more source

Neurological disorders associated with glutamic acid decarboxylase antibodies: a Brazilian series

Arquivos de Neuro-Psiquiatria, 2012
Neurological disorders associated with glutamic acid decarboxylase (GAD) antibodies are rare pleomorphic diseases of uncertain cause, of which stiff-person syndrome (SPS) is the best-known.
Maurício Fernandes, Renato P. Munhoz, Paulo Eduardo Mestrinelli Carrilho, Walter O. Arruda, Paulo J. Lorenzoni, Rosana H. Scola, Lineu César Werneck, Hélio A. G. Teive   +7 more
doaj   +1 more source

Biochemical and Enzymatic Analyses to Understand the Accumulation of γ-Aminobutyric Acid in Wheat Grown under Flooding Stress

Oxygen, 2023
Flooding induces low-oxygen stress, which reduces plant growth. The activity of the γ-aminobutyric acid (GABA) shunt is crucial for plant stress adaptation, in which it acts by changing cytosolic pH, limiting reactive oxygen species production ...
Setsuko Komatsu, Natsuru Nishiyama, Azzahrah Diniyah   +2 more
doaj   +1 more source

Altered Function of the DnaJ Family Cochaperone DNJ-17 Modulates Locomotor Circuit Activity in a Caenorhabditis elegans Seizure Model. [PDF]

, 2016
The highly conserved cochaperone DnaJ/Hsp40 family proteins are known to interact with molecular chaperone Hsp70, and can regulate many cellular processes including protein folding, translocation, and degradation.
Jin, Yishi, Takayanagi-Kiya, Seika
core   +2 more sources

The range of neurological syndromes associated with glutamic acid decarboxylase antibodies

Анналы клинической и экспериментальной неврологии, 2017
Neurological syndromes caused by production of antibodies toglutamic acid decarboxylase (GAD65) are a relatively new areaof modern clinical neurology, which is of great theoretical andpractical interest.
M. Yu. Krasnov, E. V. Pavlov, M. V. Ershova, S. L. Timerbaeva, S. N. Illarioshkin   +4 more
doaj   +1 more source

Expanding the pH range of glutamate decarboxylase from L. pltarum LC84 by site-directed mutagenesis

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: Glutamate decarboxylase is a class Ⅱ amino acid decarboxylase dependent onpyridoxal-5′-phosphate (PLP), which catalyzes the decarboxylation of substrateL-glutamate (L-Glu) to synthesize γ-aminobutyric acid (GABA).
Lijuan Yang, Lijuan Yang, Xian Zhang, Jing Chen, Yao Zhang, Zhiping Feng, Zhiping Feng   +6 more
doaj   +1 more source

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Environmental Conditions Affecting GABA Production in Lactococcus lactis NCDO 2118

Microorganisms, 2021
GABA (γ-aminobutyric acid) production has been widely described as an adaptive response to abiotic stress, allowing bacteria to survive in harsh environments.
Valérie Laroute, Roberto Mazzoli, Pascal Loubière, Enrica Pessione, Muriel Cocaign-Bousquet   +4 more
doaj   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source