Loss of mammalian glutaminase orthologs impairs sperm function in Caenorhabditis elegans
iScience, 2023 Summary: The decline in sperm function is a major cause of human male infertility. Glutaminase, a mitochondrial enzyme that catalyzes the hydrolysis of glutamine to generate glutamate, takes part in many diverse biological processes such as ...
Qifei Liang +4 more
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Interferon-α regulates glutaminase 1 promoter through STAT1 phosphorylation: relevance to HIV-1 associated neurocognitive disorders. [PDF]
PLoS ONE, 2012 HIV-1 associated neurocognitive disorders (HAND) develop during progressive HIV-1 infection and affect up to 50% of infected individuals. Activated microglia and macrophages are critical cell populations that are involved in the pathogenesis of HAND ...
Lixia Zhao +7 more
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Frontiers in Oncology, 2020 Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis, tumor growth, and the production of antioxidants through glutaminolysis in ...
Zhefang Wang +9 more
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2019 After metabolic reprogramming, many cancer cells become glutamine addicted, that is, they depend on a high consumption of this amino acid for their survival and proliferation. Glutaminase catalyzes the stoichiometric conversion of L-glutamine to L-glutamate and ammonium ions, the first step of glutaminolysis.
Campos-Sandoval, José A. +2 more
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Production, characterization, and antitumor efficiency of l-glutaminase from halophilic bacteria
Bulletin of the National Research Centre, 2022 Background Halophiles are an excellent source of enzymes that are not only salt stable, but also can withstand and carry out reaction efficiently under extreme conditions.
Eman Zakaria Gomaa
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THDP17 decreases ammonia production through glutaminase inhibition. A new drug for hepatic encephalopathy therapy. [PDF]
PLoS ONE, 2014 Ammonia production is implicated in the pathogenesis of hepatic encephalopathy (HE), being intestinal glutaminase activity the main source for ammonia.
M Mar Díaz-Herrero +8 more
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Application Prospect of Protein-Glutaminase in the Development of Plant-Based Protein Foods
Foods, 2022 Plant-based protein foods as suitable alternative protein sources have recently received increased global interest. The scientific community is exploring effective modification approaches to enhance the functionality of plant-based proteins for expanded ...
Xiao Liu +5 more
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TNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminase
Journal of Neuroinflammation, 2017 Background Extracellular vesicles (EVs) are membrane-contained vesicles shed from cells. EVs contain proteins, lipids, and nucleotides, all of which play important roles in intercellular communication.
Kaizhe Wang +6 more
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Mitochondrial GCN5L1 regulates glutaminase acetylation and hepatocellular carcinoma
Clinical and Translational Medicine, 2022 Background Glutaminolysis is a critical metabolic process that promotes cancer cell proliferation, including hepatocellular carcinoma (HCC). Delineating the molecular control of glutaminolysis could identify novel targets to ameliorate this oncogenic ...
Taotao Zhang +14 more
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Research Progress in Improving Efficacy of Radiotherapy by Targeting Glutamine Metabolism
Zhongliu Fangzhi Yanjiu, 2023 Radiotherapy is an important treatment method for malignant tumors. Radiation resistance is the main obstacle to the therapeutic effect of radiotherapy. Cellular metabolic reprogramming is one of the main features of cancer, and it may have an important ...
QIAO Wanjia, DONG Na, LIU Xiaojun
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