Results 31 to 40 of about 17,633 (189)

Erratum for the Research Article: "LncRNA GIRGL drives CAPRIN1-mediated phase separation to suppress glutaminase-1 translation under glutamine deprivation" by R. Wang <i>et al</i>.

Sci Adv
europepmc   +2 more sources

Streamlined Efficient Synthesis and Antioxidant Activity of γ-[Glutamyl]_(n≥1)-tryptophan Peptides by Glutaminase from Bacillus amyloliquefaciens

Molecules, 2023
As a group of naturally occurring peptides in various foods, γ-glutamyl peptides possess a unique Kokumi taste and health benefits. However, few studies have focused on the functionality of γ-glutamyl peptides. In this study, the γ-[glutamyl] (n=1, 2, 3)-
Wenjiang He, Xiaoling Huang, Abulimiti Kelimu, Wenzhi Li, Chun Cui   +4 more
doaj   +1 more source

Therapeutic Potential of Glutamine Pathway in Lung Cancer

Frontiers in Oncology, 2022
Cancer cells tend to obtain the substances needed for their development depending on altering metabolic characteristics. Among the reorganized metabolic pathways, Glutamine pathway, reprogrammed to be involved in the physiological process including ...
Enyu Tang, Siyang Liu, Zhiming Zhang, Rixin Zhang, Dejing Huang, Tong Gao, Tianze Zhang, Guangquan Xu   +7 more
doaj   +1 more source

Targeting glutaminase and mTOR

Oncotarget, 2015
Comprehensive genomic and proteomic analyses demonstrate that there is nearly universal activation of the PI3K pathway in glioblastoma (GBM) patients [1]. Persistent PI3K signaling promotes GBM formation and tumor progression in genetic mouse models, establishing PI3K and its effecter mTOR as compelling molecular targets.
Kazuhiro, Tanaka, Takashi, Sasayama, Eiji, Kohmura   +2 more
openaire   +2 more sources

Bioprospecting of the agaricomycete Ganoderma australe GPC191 as novel source for l-asparaginase production

Scientific Reports, 2021
l-Asparaginase is a therapeutically and industrially-competent enzyme, acting predominantly as an anti-neoplastic and anti-cancerous agent. The existing formulations of prokaryotic l-asparaginase are often toxic and contain l-glutaminase and urease ...
Meghna Chakraborty, Srividya Shivakumar
doaj   +1 more source

SNAP25 Inhibits Glioma Progression by Regulating Synapse Plasticity via GLS-Mediated Glutaminolysis

Frontiers in Oncology, 2021
BackgroundNeuronal activity regulated by synaptic communication exerts an important role in tumorigenesis and progression in brain tumors. Genes for soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) annotated with the ...
Qiongzhen Huang, Changlin Lian, Yaoyuan Dong, Huijun Zeng, Boyang Liu, Ningbo Xu, Zhenyan He, Hongbo Guo   +7 more
doaj   +1 more source

Glutamate Metabolism in Brain Structures in Experimental Hemorrhagic Shock

Общая реаниматология, 2017
Purpose. To study glutamate metabolism characteristics in phylogenetically different parts of the mammalian brain in experimentally induced hemorrhagic shock (HS) in cats.Material and methods. Experiments were performed on 76 cats.
V. N. Jakovlev, P. N. Savilov, Y. V. Bulgakova   +2 more
doaj   +1 more source

Brucella abortus modulates macrophage polarization and inflammatory response by targeting glutaminases through the NF-κB signaling pathway

Frontiers in Immunology, 2023
ObjectivesThe mechanism of Brucella infection regulating macrophage phenotype has not been completely elucidated until now. This study aimed to determine the mechanism of Brucella abortus in the modulation of macrophage phenotype using RAW264.7 cells as ...
Tianyi Zhao, Zedan Zhang, Yitao Li, Zhihua Sun, Liangbo Liu, Xingmei Deng, Jia Guo, Dexin Zhu, Shuzhu Cao, Yingjin Chai, Usevich Vera Nikolaevna, Usevich Vera Nikolaevna, Suleimenov Maratbek, Suleimenov Maratbek, Zhen Wang, Hui Zhang   +15 more
doaj   +1 more source

The Glutaminase-Dependent System Confers Extreme Acid Resistance to New Species and Atypical Strains of Brucella

Frontiers in Microbiology, 2017
Neutralophilic bacteria have developed specific mechanisms to cope with the acid stress encountered in environments such as soil, fermented foods, and host compartments. In Escherichia coli, the glutamate decarboxylase (Gad)-dependent system is extremely
Luca Freddi, Maria A. Damiano, Laurent Chaloin, Eugenia Pennacchietti, Sascha Al Dahouk, Stephan Köhler, Daniela De Biase, Alessandra Occhialini   +7 more
doaj   +1 more source

The Effect of Fertilizers in Amidohydrolases enzymes in sunflower (Helianthus annuus) Rhizoshper [PDF]

Al-Qadisiyah Journal For Agriculture Sciences, 2016
To study the enzymes activity for (Amidase , Urease , L-Asparaginase , L-Glutaminase and L-Aspartase) in sunflower plant rhizosphere in two different textures and the effect of the fertilizers kinds (mineral fertilizer , organic fertilizer and ...
Luma .S.J. Al-Taweel
doaj   +1 more source