Results 51 to 60 of about 17,633 (189)

Glutaminase Increases in Rat Dorsal Root Ganglion Neurons after Unilateral Adjuvant-Induced Hind Paw Inflammation

Biomolecules, 2016
Glutamate is a neurotransmitter used at both the peripheral and central terminals of nociceptive primary sensory neurons, yet little is known concerning regulation of glutamate metabolism during peripheral inflammation.
E. Matthew Hoffman, Zijia Zhang, Ruben Schechter, Kenneth E. Miller   +3 more
doaj   +1 more source

Supplementary Figure 4 from Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

, 2023
Matt I. Gross, Susan D. Demo, Jennifer B. Dennison, Lijing Chen, Tania Chernov-Rogan, Bindu Goyal, Julie Janes, Guy J. Laidig, Evan R. Lewis, Jim Zhang Hao Li, Andrew L. MacKinnon, Francesco Parlati, Mirna L.M. Rodriguez, Peter J. Shwonek, Eric B. Sjogren, Timothy F. Stanton, Taotao Wang, Jinfu Yang, Frances Zhao, Mark K. Bennett   +19 more
openalex   +1 more source

Glutaminase: A Hot Spot For Regulation Of Cancer Cell Metabolism? [PDF]

, 2010
Jon W. Erickson, Richard A. Cerione
openalex   +1 more source

Glutaminase inhibition as potential cancer therapeutics: current status and future applications

Journal of Enzyme Inhibition and Medicinal Chemistry
Alterations in normal metabolic processes are defining features of cancer. Glutamine, an abundant amino acid in the human blood, plays a critical role in regulating several biosynthetic and bioenergetic pathways that support tumour growth. Glutaminolysis
Rajath Cyriac, Kwangho Lee
doaj   +1 more source

Dual targeting of EGFR and glutaminase in lung cancer

Molecular & Cellular Oncology, 2018
We have recently demonstrated that targeted inhibition of epidermal growth factor receptor (EGFR) signaling and glutaminase led to metabolic crisis in EGFR mutant lung adenocarcinomas and significant tumor regression in mouse xenograft models.
Milica Momcilovic, David B. Shackelford
doaj   +1 more source

Glutamine addiction: an Achilles heel in esophageal cancers with dysregulation of CDK4/6

Molecular & Cellular Oncology, 2019
Understanding and overcoming resistance to cyclin-dependent kinase 4/6 (CDK4/6) inhibitors will be challenging. Recent work reveals that dysregulation of F-Box Protein 4 (FBXO4)-Cyclin D1 axis leads to mitochondrial dysfunction and drives glutamine ...
Shuo Qie, J. Alan Diehl
doaj   +1 more source

Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer [PDF]

, 2020
Dean C. Singleton, Anne-Lise Dechaume, Pamela M. Murray, William P. Katt, Bruce C. Baguley, Euphemia Leung   +5 more
openalex   +1 more source

An Overview of Asparaginase Enzyme Features: An Anticancer Enzyme with High Potency

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2019
Introduction: One of the important findings in the pharmaceutical and medical industry is the use of the asparaginazase enzyme as an anticancer drug. The asparaginase enzyme, hydrolyzing the amino acid of asparagine, reduces this amino acid in the blood ...
Gholam Hossein Ebrahimipour, Mahtab Ghorban Movahed   +1 more
doaj  

Safety evaluation of the food enzyme glutaminase from the non‐genetically modified Bacillus amyloliquefaciens strain AE‐GT

EFSA Journal
The food enzyme glutaminase (l‐glutamine amidohydrolase; EC 3.5.1.2) is produced with the non‐genetically modified Bacillus amyloliquefaciens strain AE‐GT by Amano Enzyme Inc.
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Vittorio Silano, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Claude Lambré, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger‐Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Magdalena Andryszkiewicz, Daniele Cavanna, Yi Liu, Simone Lunardi, Elsa Nielsen, Karin Norby, Giulio diPiazza, Yrjö Roos, Andrew Chesson   +26 more
doaj   +1 more source

Alpha and Omega Classification of β-Lactamase/Transpeptidase-like Superfamily Proteins Based on the Comparison of Their Structural Catalytic Cores

Molecules
β-Lactamase/transpeptidase-like superfamily proteins are serine proteases that use the Ser–Lys catalytic dyad to carry out their biological functions. Here, we investigate the three known families of β-lactamase/transpeptidase-like superfamily proteins ...
Alexander I. Denesyuk, Konstantin Denessiouk, Mark S. Johnson, Vladimir N. Uversky   +3 more
doaj   +1 more source