Results 151 to 160 of about 482,280 (260)

Dissecting mechanisms of ligand binding and conformational changes in the glutamine-binding protein. [PDF]

Elife
Han Z, Panhans S, Brameyer S, Bilgen E, Ram M, Herr A, Narducci A, Isselstein M, Harris PD, Brix O, Con P, Jung K, Lamb DC, Lerner E, Griffith D, Weikl TR, Zijlstra N, Cordes T.   +17 more
europepmc   +1 more source

Combining Fret and Super‐Resolution Microscopy Reveals Kinase Activation and Mitochondrial Activity at the Nanoscale

Advanced Science, EarlyView.
BioSenSRRF is an open‐source workflow that combines conventional FRET biosensors with SRRF reconstruction to generate sub‐diffraction FRET index maps on standard microscopes. The pipeline integrates automated image registration, SRRF reconstruction, quantitative FRET index calculation, and random line‐based hotspot analysis to uncover AURKA‐dependent ...
Nicolas Y. Jolivet, Pierre‐Jean Desmaison, Xavier Pinson, Arthur Masson, Olivier Delalande, Giulia Bertolin   +5 more
wiley   +1 more source

A ketogenic diet sensitizes pancreatic cancer to glutamine metabolism inhibitors. [PDF]

Cell Rep Med
Hajihassani O, Roichman A, Boyer JA, MacArthur M, Cordova R, Loftus A, Boutros CS, Hue JJ, Naji P, Tahhan S, Gallagher P, Beegan W, Shah D, Choi J, Manzoor N, Lei S, Kim C, Rathore M, Shah I, Lebo K, Cheng H, Mudigonda A, Hunter C, Zarei M, Alibeckoff S, Ji K, Graor H, Miyagi M, Vaziri-Gohar A, Brunengraber H, Wang R, Lund PJ, Rothermel LD, Rabinowitz JD, Winter JM.   +34 more
europepmc   +1 more source

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

Critical Role for Malic Enzymes in MYC-Mediated Cellular Adaptation to Glutamine Depletion. [PDF]

Metabolites
Si Y, Li W, Chen Y, Yuan J, Hu C, Liu Y, Li L.   +6 more
europepmc   +1 more source

Cigarette Smoke‐Induced Alveolar Macrophage Senescence via GEM/SIRT3‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang, Meidan Wei, Xiangrong Song, Jiaxin Zhang, Lisha Zhang, Sixian Chen, Yaoyu Hu, Hui Gao, Jianxiang Li   +8 more
wiley   +1 more source

Corrigendum: Protein Kinase C Phosphorylates the System N Glutamine Transporter SN1 (Slc38a3) and Regulates Its Membrane Trafficking and Degradation

Frontiers in Endocrinology, 2017
Lise Sofie H. Nissen-Meyer, Lise Sofie H. Nissen-Meyer, Farrukh Abbas Chaudhry, Farrukh Abbas Chaudhry   +3 more
doaj   +1 more source

Glutamine-driven reductive TCA cycle metabolism supports aged muscle stem cell function via de novo lipogenesis. [PDF]

Nat Aging
Lee DE, McKay LK, Bareja A, Yang J, He W, Hill DA, Bain JR, Kuang S, Zhang GF, Newgard CB, White JP.   +10 more
europepmc   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Semaglutide targets muscle mitochondria to regulate glutamine metabolism and treat osteoarthritis. [PDF]

iScience
Tian Y, Zheng Z, Ma Y, Ye F, Pang Y, Zhang Z, Li Z, Zhang C, Gao J.   +8 more
europepmc   +1 more source